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The skill suggests adding a calcimimetic for hypercalcemia of malignancy due to parathyroid carcinoma that persists after intravenous bisphosphonate or denosumab therapy. It is triggered when a clinician notes refractory HCM despite antiresorptive therapy and considers adding a calcimimetic.
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Recommends adding intravenous bisphosphonate or denosumab when hypercalcemia due to parathyroid carcinoma is not adequately controlled with a calcimimetic. Consider this adjunct when a clinician notes persistent HCM despite calcimimetic therapy and asks about next-step therapy.
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This skill suggests treatment with either a calcimimetic or an intravenous bisphosphonate/denosumab for hypercalcemia due to parathyroid carcinoma. Triggered when a clinician diagnoses parathyroid carcinoma-associated hypercalcemia of malignancy and inquires about initial medical management options.
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Expert-level calculus knowledge. Use when working with limits, derivatives, integrals, multivariable calculus, vector calculus, differential equations, series, or optimization. Also use when the user mentions 'derivative', 'integral', 'limit', 'chain rule', 'gradient', 'divergence', 'curl', 'Taylor series', 'Fourier series', 'partial derivative', 'double integral', 'line integral', 'Stokes theorem', or 'Lagrange multipliers'.
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Calculate and model paid-media CPA, CPL, CPC, CPM, ROAS, MER, break-even targets, contribution margin, LTV:CAC, impression-share opportunity, budgets, forecasts, and experiment economics. Use for PPC math, ad calculator, break-even analysis, ROAS calculator, CPA calculator, budget forecast, LTV CAC, or MER.
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Build Excel workbooks for buyouts financed with debt. Using a supplied or standard template, the skill connects funding, operating forecasts, debt repayment, and returns, calculating IRR, an annualized return measure, and MOIC, the investment multiple.
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Evaluate whether tests catch defects in business logic, calculations, or state machines. Using Stryker, the skill introduces small code changes, reviews which changes escape detection, and helps strengthen tests where important behavior is insufficiently checked.
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Create, edit, and clean spreadsheet files, including Excel workbooks and CSV data. Build formulas and formatting with openpyxl, a Python library, then recalculate and validate workbooks to check for formula errors and file problems.
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Calculate financial ratios from company statements to assess profitability, ability to cover obligations, efficiency, and valuation. Results include explanations, comparisons across periods, available industry benchmarks, and a formatted Excel report.
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Use SymPy to simplify expressions, solve equations, and calculate derivatives, integrals, and matrices with exact symbolic results. Specify assumptions, verify solutions, and turn mathematical expressions into numerical functions, source code, or LaTeX output.
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Measure fluid velocity from pairs of particle images with OpenPIV. The skill covers image preparation, velocity calculation, correction of unreliable vectors, plotting, and calculation of vorticity and strain rate to examine flow patterns.
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Calculate portfolio risk and performance measures, including potential losses, declines from past peaks, and returns relative to risk. Use multiple indicators to support risk limits, position sizing, and ongoing monitoring.
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Design KPI dashboards that help teams make decisions using clearly defined performance measures. Choose relevant metrics, organize summary and detail views, document calculations, and address inconsistent figures, database load, and excessive alerts.
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Analyze option strategies with profit and loss charts, breakeven points, and maximum risk calculations. Compare single options and combinations, and explore how underlying prices and volatility affect theoretical values for research and backtesting.
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Plan and evaluate free calculators, generators, or assessment tools for marketing. Compare ideas by audience needs, search demand, and development effort, then outline essential features, email signup options, promotion, and success metrics.
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Plan customer acquisition through paid ads, SEO, and partnerships for growing B2B SaaS startups. Includes campaign templates, customer acquisition cost calculations, and HubSpot tracking guidance to connect marketing activity with sales opportunities.
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Analyze social media post data to calculate engagement, click rates, and estimated returns on advertising spend. Compare results with supplied platform benchmarks, identify strong and weak posts, and generate recommendations for improving campaign performance.
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Analyzes marketing campaign data to compare channel contributions, find drop-offs before purchase, and calculate returns and acquisition costs. Uses five attribution models, which assign credit to customer interactions, with results available as readable summaries or JSON.
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Define service reliability targets, choose measurements that reflect user experience, and calculate error budgets—the failures a target allows. Generate alert thresholds and review existing definitions for unrealistic targets, unclear metrics, and missing response policies.
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Modify Handsontable’s Walkontable rendering engine using its architecture and coding rules. The skill covers visible-area calculations, frozen rows and columns, scroll synchronization, browser element measurements, and tests for rendering changes.
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Monitor TPU workloads on GKE using system metrics and PromQL, a metrics query language. Check utilization, memory, node availability, and interruptions to investigate infrastructure issues and calculate average recovery times and intervals between interruptions.
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Add a model pricing field throughout Bifrost, from datasheet parsing and database storage to cost calculations, overrides, documentation, and UI controls. Verify calculation and repeat-sync behavior with tests, then check the repository for missed integration points.
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Estimate market size at three levels: total demand, the market your product can serve, and the share it could realistically capture. Use supplied figures or guided research to produce calculations with explicit assumptions, sources, and constraints.
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Find key figures in tabular data using column names or row keywords, calculate category averages and percentages, and export the results as a structured Excel report and a pie chart.
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