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Design courses where learners explore ideas by changing parameters, following diagrams, running code, playing games, or inspecting 3D scenes. Each main page focuses on one mechanism or structure, with opening and closing pages framing the learning.
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Prepare for an upcoming workday by combining Outlook meetings with open tasks and workspace context. Generate an HTML briefing with meeting preparation, scheduling conflicts, suggested priorities, and available time for learning and focused work.
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Build normal traffic profiles for industrial control networks and identify unusual connections, polling intervals, and protocol operations. Use machine learning and process records to investigate deviations and produce anomaly reports with severity levels.
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Guides large language model reinforcement learning with miles, covering environment setup, low-precision training, consistency between training and inference, and speculative decoding, where a smaller model proposes tokens for a larger model to verify.
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Plan smart contract audits using research from security organizations. Combine threat modeling, static code analysis, fuzzing that varies test inputs, and manual review, while using attack patterns and a four-phase roadmap to guide further learning.
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Guides large language model reinforcement learning with miles, including MoE models that route work to specialized components. Covers low-precision training, matching training and inference behavior, and accelerating training response generation with draft models.
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Explain code, design concepts, and system behavior at a chosen level of detail. Get a brief overview or a deeper walkthrough covering execution flow, design choices, alternatives, usage examples, and related code.
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Refactor claude-flow into an extension of agentic-flow@alpha to reduce duplicate implementations. Plan adapter layers, migrate agent and task management, and connect learning, shared memory, and tools while checking compatibility with existing functionality.
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Explain machine learning predictions with SHAP values, which measure how each input contributes to an output. Create charts for individual predictions and overall feature importance, investigate errors, compare models, and examine differences between groups.
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Structure PyTorch training code with PyTorch Lightning, separating model logic, data preparation, and training settings. Use templates and configuration examples to add checkpoints, experiment logs, and distributed training that runs across multiple GPUs or TPUs.
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Convert existing Hugging Face Trainer or TRL SFTTrainer code into an NVFLARE job for federated learning, where multiple sites train a shared model. Preserve training settings, validate locally, and export the resulting job.
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Discovers de novo motifs and tests known motif enrichment in ChIP-seq, ATAC-seq, or other peak sequences using HOMER, MEME-ChIP (STREME, CentriMo, TOMTOM, FIMO), monaLisa, and AME. Handles background selection (GC-matched, dinucleotide-shuffled, Markov order-2, peak-flanks), motif databases (JASPAR 2024 CORE PWMs, JASPAR 2026 deep-learning collection, HOCOMOCO v12, HOMER built-in), centrally-enriched motif testing, and differential motif analysis. Use when identifying TF binding motifs in peaks, testing for known TF enrichment, scanning for motif instances, comparing motif content between conditions, or interpreting motifs from deep learning models.
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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.
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Deep learning for single-cell analysis using scvi-tools. This skill should be used when users need (1) data integration and batch correction with scVI/scANVI, (2) ATAC-seq analysis with PeakVI, (3) CITE-seq multi-modal analysis with totalVI, (4) multiome RNA+ATAC analysis with MultiVI, (5) spatial transcriptomics deconvolution with DestVI, (6) label transfer and reference mapping with scANVI/scArches, (7) RNA velocity with veloVI, or (8) any deep learning-based single-cell method. Triggers include mentions of scVI, scANVI, totalVI, PeakVI, MultiVI, DestVI, veloVI, sysVI, scArches, variational autoencoder, VAE, batch correction, data integration, multi-modal, CITE-seq, multiome, reference mapping, latent space.
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Deep generative models for single-cell omics: probabilistic batch correction (scVI), semi-supervised annotation (scANVI), CITE-seq RNA+protein (totalVI), transfer learning (scARCHES), and DE with uncertainty. Unified setup→train→extract API on AnnData. Use harmony-batch-correction for fast linear correction without deep learning; muon for multi-modal MuData workflows.
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Deep learning for drug discovery. 60+ models (GCN, GAT, AttentiveFP, MPNN, ChemBERTa, GROVER), 50+ featurizers, MoleculeNet benchmarks, HPO, transfer learning. Unified load-featurize-split-train-evaluate API. For fingerprints use rdkit-cheminformatics; for featurization-only use molfeat.
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Operate the Deep Researcher Agent repository for autonomous deep-learning experiments, execution backends, provider/tool dispatch, GPU resources, durable progress, and research-support integrations.
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Applies the reasoning, principles, and frameworks of Andrew Ng (machine learning pioneer, co-founder of Coursera and DeepLearning.AI, Stanford University, and former Google Brain lead). Use this skill whenever the user is navigating AI application development, agentic workflows, automation strategy, AI-native software engineering, or rapid prototyping. Trigger this skill when discussing career advice in the AI era, evaluating AI regulations, structuring machine learning projects, or deciding how to integrate AI into a business. It emphasizes task-based automation, data-centric ML, and driving the cost of proof-of-concepts to zero.
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Applies the mental models and frameworks of Andrej Karpathy (deep learning, former Director of AI at Tesla, founding member of OpenAI, Eureka Labs). Use this skill whenever you are helping the user build neural networks from scratch, debug deep learning pipelines, evaluate AI agent workflows, design LLM apps, or navigate the transition to Software 3.0 (vibe coding). It is highly relevant for pedagogy (untangling complex knowledge), assessing AI capabilities vs. limitations (jagged intelligence, tokenization limits), and architectural decisions (end-to-end optimization vs. complex pipelines). Reach for this whenever discussing LLM training, autonomous systems, or AI-assisted coding.
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Use this skill when reasoning about generative AI, adversarial machine learning, neural network security, algorithmic fairness, or deep learning fundamentals. This skill channels the thinking of Ian Goodfellow, inventor of Generative Adversarial Networks (GANs). Trigger this skill when the user asks about model robustness, mitigating bias, evaluating AI guardrails, designing generative models, or defending against adversarial attacks. Apply his frameworks of minimax games, adversarial feature learning, and worst-case robustness analysis to shift the user's perspective from average-case optimization to adversarial resilience.
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Applies the reasoning style of Geoffrey Hinton, deep learning pioneer and 2018 Turing Award winner. Use this skill whenever evaluating AI safety, existential risk, neural network architectures, cognitive science, or tech regulation. Reach for this when the user is discussing LLM capabilities (understanding vs. autocomplete), the biological vs. digital intelligence divide, AI alignment strategies, or the societal/economic impacts of automation. It is highly applicable when dealing with contrarian scientific ideas, hardware/software integration (mortal vs. immortal computing), or global cooperation on technological threats. Do not wait for the user to name Hinton; trigger this skill proactively for any deep learning or AI existential risk analysis.
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Applies the reasoning of David Silver, lead researcher on AlphaGo and AlphaZero at DeepMind, to problems of AI design, reinforcement learning, and open-ended discovery. Use this skill whenever you are designing AI systems, evaluating learning algorithms, balancing exploration vs. exploitation, choosing research problems, or discussing how to break past human performance ceilings. Reach for this whenever the user asks about self-play, Monte-Carlo Tree Search, tabula rasa learning, AGI, or moving from human-curated data to autonomous experience. It helps shift the focus from hardcoding human knowledge to building systems that learn for themselves.
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ANDREJ KARPATHY — SKILL COMPLETA v2.0 workflow skill. Use this skill when the user needs Agente que simula Andrej Karpathy — ex-Director of AI da Tesla, co-fundador da OpenAI, fundador da Eureka Labs, e o maior educador de deep learning do mundo and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
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ANDREJ KARPATHY — SKILL COMPLETA v2.0 workflow skill. Use this skill when the user needs Agente que simula Andrej Karpathy — ex-Director of AI da Tesla, co-fundador da OpenAI, fundador da Eureka Labs, e o maior educador de deep learning do mundo and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
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