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Prioritizes candidate genes from GWAS, studies linking genetic variants to traits. Combines locus predictions, gene expression evidence, and rare variant support into ranked results with source attribution, confidence labels, reproducible files, and optional figures.
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Analyze a monolithic codebase before splitting it into modules or services. The skill inventories components, examines duplication, hierarchy, and dependencies, then proposes groupings aligned with business domains, with optional checks against business terminology and boundaries.
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Compare choices using weighted scores, pros and cons, possible failure scenarios, and what each option means giving up. Make preferences and uncertainty explicit, rank alternatives, and identify information that could change the decision.
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Structure open-source intelligence research, meaning investigation using publicly available information, for authorized external assessments. Map organizational assets, record evidence and confidence levels, prioritize exposures, and prepare reports that explain technical findings and business risks.
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Research industrial AI topics such as predictive maintenance and anomaly detection. Compare papers by methods and publication venues, distinguish preprints from reviewed work, identify conflicting findings and research gaps, or build an evidence-based survey draft.
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Review external pull requests and issues in public GitHub repositories by checking whether they address real user problems. It helps assess proposed improvements, question hypothetical issues, and inform prioritization or replies without treating AI use alone as suspicious.
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Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.
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Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.
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Comprehensive OSINT methodology for external red-team operations and authorized attack-surface assessments. Covers the 6-stage recon pipeline (seed → asset expansion → enrichment → exposure analysis → convergence → operator-armed active validation) with connector-resilience and stage-vs-gating discipline, asset-graph discipline, severity rubric, confidence upgrade workflows, time budgeting, identity-fabric mapping, breach×identity correlation with per-person identity dossiers, detectability tagging, detection-aware probing, WAF/CDN bypass, vulnerability prioritization, phishing infrastructure planning, bug bounty submission, and client deliverable templates. Use when planning or executing reconnaissance against authorized targets, mapping an organization's external attack surface, investigating a person/entity, or producing client deliverables.
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Runs the loop from discovering a weakness to confirming it is fixed — scanning, triage, prioritization by real exploitability, remediation tracking, and patch policy. Use this to stand up or fix a vulnerability program, triage scanner output, decide what to fix first, set patch SLAs, handle a disclosure from an outside researcher, or report posture to leadership.
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Runs the IT service desk — intake, triage, prioritization, escalation, knowledge, and the metrics that improve service rather than distort it. Use this to set up or fix a service desk, design ticket priority and escalation, reduce repeat contacts, structure a knowledge base, or work out why a desk hitting its targets still frustrates everyone.
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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
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Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Generates complete comparative network-toxicology research designs from a user-provided exposure pair, shared toxic phenotype, and validation direction. Use when a study centers on two related exposures under one outcome and needs target collection, shared-vs-specific target decomposition, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-checks, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.
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Generates complete conventional oncology bulk-transcriptome biomarker and hub-gene research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, prognostic filtering or risk modeling, PPI-based hub-gene prioritization, diagnostic/prognostic evaluation, clinical association, immune infiltration context, methylation context, and optional tissue or cell validation. Covers five study patterns (signature-first prognostic workflow, hub-gene-first biomarker workflow, hybrid signature-to-hub workflow, immune-context biomarker workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
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Generates complete cross-disease shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Always use this skill whenever a user wants to design, plan, or build a multi-dataset study linking two related diseases through shared DEGs, enrichment, PPI hub genes, public validation, regulatory-network analysis, immune infiltration, drug-gene interaction screening, and optional qRT-PCR or cell-line validation. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, regulatory-network interpretation, immune/drug follow-up, bioinformatics-plus-validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.
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Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
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Generates complete single-compound network-toxicology research designs from one exposure, one disease or toxic phenotype, and a validation direction. Use when a study centers on one compound–one disease link and needs target collection, overlap construction, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-check, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Help users move from reactive feature-building to strategic resource allocation by applying rigorous scoring, financial modeling, and portfolio balancing.
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Product manager that decomposes requirements into actionable tasks with priorities and dependencies. Use for planning, requirements, specification, scope, prioritization, task breakdown, and ISO 21500, ISO 31000, or ISO 38500-aligned planning recommendations.
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Architecture specialist for software/system design, module and service boundaries, tradeoff analysis, and stakeholder synthesis. Uses context-aware methods such as diagnostic routing, design-twice comparison, ATAM-style risk analysis, CBAM-style prioritization, and ADR-style decision records.
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Turn product requirements into scoped tasks with dependencies and acceptance criteria. Use for implementation planning and prioritization.
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