“zero”的搜索结果

Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools (bedGraphToBigWig, bigWigToBedGraph, bigWigInfo, bigWigSummary, bigWigAverageOverBed) and deepTools (multiBigwigSummary, computeMatrix, bigwigCompare). Covers the central trap that a wide query returns a precomputed zoom-level summary (by default the mean, which annihilates narrow peaks) not per-base data, when exact=True/values() is mandatory, the NaN-not-zero gap-handling fork, choosing mean vs max vs sum vs coverage by biological question, and the sorted-bedGraph plus chrom.sizes build requirement. Use when extracting signal at regions, computing mean signal per gene/peak, building a browser track from bedGraph, comparing tracks, or building TSS/gene-body metaprofiles.

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Extracts, filters, annotates, and exports differential expression results from DESeq2 or edgeR with proper handling of padj=NA (independent filtering, Cook's outliers, all-zero), multiple-testing correction choice (BH vs Storey q-value vs IHW vs lfsr), TREAT vs post-hoc fold-change filtering, p-value histogram diagnostics, gene annotation via org.db/biomaRt/mygene, GSEA preranked input, ORA background construction, replication reality (Schurch 2016 small-n result), and SABV/sex-stratified reporting. Use when extracting and interpreting DE results, troubleshooting padj=NA, choosing FDR method, preparing ranked lists for pathway analysis, annotating gene IDs, or comparing DESeq2 vs edgeR outputs.

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Use this skill when the user asks about onboarding a new CDL driver — pre-hire process, day-zero requirements, application + DQF setup, road test, drug & alcohol pre-employment, Clearinghouse Full query, MVR initial pull, PSP report, ELDT verification, sequence of activities + timing, and what NOT to do (handing keys before testing complete). Cite 49 CFR 391, 382.

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Classify every destructive/gated action an agent body can attempt (git, filesystem, network, shell, github) into block/approve/allow tiers, and audit whether the pre-tool and post-tool governance backing that classification is real: blocked actions proven zero-side-effect by a negative fixture, every denial backed by a receipt and a transcript event, every block-tier denial paired with a safe alternative, and no unmanaged or same-UID body ever marked "contained." Use when building or reviewing Agent Harbor's C5 governance gate (destructive git blocker, approval request/result, denial receipts), gating a new tool surface before it can run destructive commands, or auditing whether an existing "destructive-action blocked" claim actually has evidence behind it. NOT for proving an existing sandbox boundary actually contains an adversary once an action is isolated (use sandboxed-adversarial-test-harness), deciding where in a DAG to place a human review node or designing the approval UX itself (use human-gate-designer), or designing the general work-receipt schema across an entire agent task (use agent-work-receipt-designer).

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Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.

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Use when wrangler deploys silently fail or produce wrong artifacts, secrets upload as empty strings, custom domain DNS is not resolving, route assignment broke after rename, observability/tail logs are needed, D1/KV/R2 bindings are missing, OAuth scope errors block a command, cookies on a redirect are not attaching, or the worker exceeds CPU time. Triggers: "Tenant or user not found", "Authentication error" on wrangler d1 push, secret length is 0 after upload, route returns origin not worker, "compatibility_date too old", 1101 errors, custom_domain assignment lost on script rename. NOT for AWS Lambda / Vercel Edge / Deno Deploy (different runtimes), Cloudflare Zero Trust, or R2-specific tuning.

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Guides Cloudflare One Zero Trust and SASE work across Access, Gateway, WARP, Tunnel, Cloudflare WAN, DLP, CASB, device posture, and identity. Use when designing, configuring, troubleshooting, or reviewing Cloudflare One deployments. Retrieval-first: use current Cloudflare docs/API schemas instead of embedded product docs.

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Audits an Articles of Agreement contract — the daemon-witnessed agreement every official Port Daddy agent signs covering registration, transcript reporting, tool-use gating, file claims, parley conduct, budget limits, and operator control — against the enforcement-beats-hope bar: a clause counts as safe only when it resolves to a concrete, daemon-observable mechanism with a defined denial shape, never a promise the agent might honor. Use when drafting a new agent's Articles, reviewing a compliance-level (C0-C6) claim, deciding whether a clause is genuinely enforced or merely documented, or auditing whether an agent's claimed identity can be trusted. NOT for securing the inbound event-to-spawn path (fleet-event-spawn-trust), designing the relay's transport PKI and signing keys (pd-relay-zero-trust), or tracking an agent's identity and reputation across its whole lifetime after it signs (agent-identity-continuity-reputation).

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Expert-level idiomatic Rust API design — the patterns that make illegal states unrepresentable and abstractions zero-cost. Type-state programming (PhantomData state machines), newtype + sealed + extension traits, typestate builders, RAII guards & Drop ordering, the interior-mutability decision tree (Cell/RefCell/Mutex/RwLock/Atomic/OnceLock), enum-driven state machines, error architecture (thiserror vs anyhow), dyn vs generic dispatch & object safety, the impl Trait / GAT / RPITIT toolbox, and Deref-for-smart-pointers (and its abuse). Use when designing a Rust library's public API, encoding invariants in the type system, choosing a dispatch or error strategy, or reviewing Rust for idiom. NOT for borrow-checker firefighting / toolchain / test-runner workflow (use rust-development-workflow), NOT for pd-console GPUI rendering/layout/panes (use gpui-rust-console), NOT for app packaging/notarization (use rust-app-distribution).

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The doctrine for turning a vision into a finished, verified, deployed system with near-zero owner involvement. Use when launching, coordinating, resuming, or working any large build, module, campaign, or multi-agent project, or when writing its launch prompt.

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Locate CEconItemView::CEconItemView in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CEconItemView::CEconItemView" (symbol CEconItemView_CEconItemView). This is the CONSTRUCTOR of CEconItemView. Shortlist via allocation sites: callers of operator-new whose result is immediately stored with the CEconItemView vtable (RTTI), followed by zeroing and initialization of definition-index/quantity/attribute-list fields. Distinguish from subobject constructors of derived classes by the vtable identity. Trigger: CEconItemView_CEconItemView, CEconItemView::CEconItemView

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Find and identify the CBaseEntity::TakeDamageOld function in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the legacy damage-application entry point by finding the code that references its self-identifying assert/warning message "CBaseEntity::TakeDamageOld: damagetype %d with info.GetDamageForce() == Vector::vZero". Trigger: CBaseEntity_TakeDamageOld

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GitHub プロジェクト管理を一括操作。Issue作成、ラベル設定、プロジェクト紐付け、マイルストーン、日付、ステータス変更。 トリガー例: 「Issue作成」「プロジェクト管理」「project-mgmt」「Issueを立てて」「プロジェクトに追加」

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計画からIssueを作成 + プロジェクトに登録（plan + project-mgmt）。 トリガー例: 「/reg-issue ユーザー認証機能を追加して」

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Best practices for Remotion - Video creation in React

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差分からIssueを作成 + プロジェクトに登録 + サブイシューごとのコミット + Gitフロー（analyze-diff + plan + project-mgmt）。 トリガー例: 「/reg-commit」

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Git Flow ワークフローで開発からdevelopへのマージまでを実行。 「フィーチャーブランチ作って」「PR出して」「コードレビューして」「マージして」などのリクエスト時に使用。 開発中の差分がある状態からブランチを作成します。 develop → main のリリースフローもサポート。 ※ develop → main のマージは人間が実行します。

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Generate blog articles for Qiita and Zenn from GitHub release information. Use when creating release notes or technical articles that follow specific markdown formats with frontmatter. Supports generating articles from release data, creating custom formatted articles, and saving articles to specified repositories for both Qiita and Zenn platforms

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既存GitHubリポジトリのメンテナンス（リリース、変更履歴、Issue等）。ghコマンド使用。 トリガー例: 「リリースノート」「リリース」「issue」「repo-maintain」 ※ PR 作成・マージは repo-flow スキルを使用

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Claude Codeの拡張機能（スキル、サブエージェント、プロジェクト設定）をユーザーの自然言語指示から自動生成するスキル。「○○を作るスキルを作って」「○○エージェントを作って」「CLAUDE.mdを設定して」などのリクエスト時に使用。v2.1.1以降、スラッシュコマンドとスキルは統合されたため、すべてスキルとして作成。

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差分からIssueを作成 + プロジェクトに登録 + 複数コミット + プッシュ + PR作成で終了（analyze-diff + project-mgmt + repo-flow PR作成まで）。 サブイシューを作成せず、1つのIssueのみを作成し、ファイル単位・機能単位で複数のコミットに分けるフラットなパターン。 マージは実行せず、PR作成で終了します。 トリガー例: 「/reg-commit-pr」

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差分からIssueを作成 + プロジェクトに登録 + 複数コミット + Gitフロー（analyze-diff + project-mgmt + repo-flow）。 サブイシューを作成せず、1つのIssueのみを作成し、ファイル単位・機能単位で複数のコミットに分けるフラットなパターン。 トリガー例: 「/reg-commit-flat」

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AIエージェントのキャラクター定義ファイルを生成するスキル。ユーザーがキャラクター設定（名前、二つ名、年齢、属性、性格、支配の流儀、口癖、外見、絵文字など）を入力すると、それに基づいてIDENTITY.md、SOUL.md、USER.md、AGENTS.md、TOOLS.md、BOOTSTRAP.md、HEARTBEAT.mdの7つのファイルとavatar.pngを配置したキャラクターディレクトリを作成する。また、agent-identity/README.md にキャラクター情報とアバター画像を追加する。ユーザーが「キャラクターを作って」「新しいキャラクターを追加して」「○○っていうキャラクターのファイル作って」と言った時や、キャラクター設定を詳細に提供した時に使用する。

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Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.

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