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当物理问题的方程列得出来却解不动、能量算不平、或者根本不知道往哪个方向列方程时使用。先把过程按约束改变、接触建立断开、打滑、相变、冲量作用切成阶段，标出每段守恒什么、哪里突变、阶段之间靠什么衔接；再为每个阶段配一个能直接回答本段问题的表示（受力图、冲量-动量表、势能曲线、相图、质心系、有效势、相量、无量纲化、对称性）。给的是看问题的角度，不是解。

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Structure any communication artifact — documents, reports, plans, issue comments, PR descriptions, emails, presentations, slides, charts, and dashboards — using Jean-luc Doumont's "Trees, Maps, and Theorems" method. Use whenever the goal is to get a message across to a busy audience, when asked to improve clarity or structure of writing or slides, or when a deliverable will be judged by whether readers act on it, not just read it.

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Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity. Perfect for preparing images for presentations, documentation, or social media posts.

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Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with CVD-safe palettes, cairo_pdf TrueType embedding, programmatic aes via tidy evaluation, and the theme_classic publication baseline. Use when producing static figures in R for papers, presentations, or reports.

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Provides guidance for training and analyzing Sparse Autoencoders (SAEs) using SAELens to decompose neural network activations into interpretable features. Use when discovering interpretable features, analyzing superposition, or studying monosemantic representations in language models.

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Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.

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Maps metabolomics results to biological pathways via over-representation (ORA), metabolite-set enrichment (MSEA/QEA), mummichog/PSEA on raw m/z peaks, and network-diffusion enrichment (FELLA), with correct background-set construction and honest interpretive ceilings. Use when interpreting differential metabolites or an untargeted LC-MS feature table in pathway context, choosing ORA vs MSEA vs mummichog vs topology, or setting the reference/background set. For annotation confidence levels feeding ORA see metabolomics/metabolite-annotation; for gene-set concepts see pathway-analysis/go-enrichment and pathway-analysis/gsea; for joint gene+metabolite pathways see multi-omics-integration/mofa-integration.

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Draft a strong SCF Interest Form submission. Use when a team needs help writing the Interest Form that determines whether they get invited to submit a full Build Award application. Covers project positioning, Stellar integration framing, team presentation, and the concise format the Interest Form requires.

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Use when the user is explicitly working with Quarto, .qmd files, _quarto.yml, Quarto projects, or Quarto features such as callouts, cross-references, citations, Mermaid diagrams, extensions, websites, books, presentations, and reports. Also use for explicit migration from or comparison with R Markdown, bookdown, blogdown, xaringan, distill, or Jupyter notebooks to Quarto. Do not use for general R Markdown or related-format questions unless Quarto or migration to Quarto is explicitly mentioned.

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Predict peptide-MHC class II (HLA-DR/DQ/DP) binding and presentation for CD4 T-cell epitopes with NetMHCIIpan-4.3 and MixMHC2pred-2.0. Covers why class II is far less reliable than class I (open binding groove, 9-mer register ambiguity, sparse noisy training data, DR>DP>DQ accuracy asymmetry), the DQ/DP heterodimer alpha/beta pairing trap, and the looser 1%/5% %Rank thresholds. Use when predicting CD4 epitopes for vaccine help, mapping class II neoantigens, or scoring long peptides against DR/DQ/DP. For CD8/class I see mhc-binding-prediction.

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Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with CVD-safe palettes, cairo_pdf TrueType embedding, programmatic aes via tidy evaluation, and the theme_classic publication baseline. Use when producing static figures in R for papers, presentations, or reports.

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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Use when adding hypermedia links to REST responses, building self-describing APIs, or implementing Spring HATEOAS. Use when you see EntityModel, CollectionModel, or RepresentationModel in the project.

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Use this skill when the user requests to generate, create, or make presentations (PPT/PPTX). Creates visually rich slides by generating images for each slide and composing them into a PowerPoint file.

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Provides guidance for training and analyzing Sparse Autoencoders (SAEs) using SAELens to decompose neural network activations into interpretable features. Use when discovering interpretable features, analyzing superposition, or studying monosemantic representations in language models.

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生成"电子杂志 × 电子墨水"风格的横向翻页网页 PPT（单 HTML 文件），含 WebGL 流体背景、衬线标题 + 非衬线正文、章节幕封、数据大字报、图片网格等模板。当用户需要制作分享 / 演讲 / 发布会风格的网页 PPT，或提到"杂志风 PPT"、"horizontal swipe deck"、"editorial magazine"、"e-ink presentation"时使用。

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Launch, inspect, or tear down an isolated fleet of ready SDD Composy tasks: one branch and Git worktree per member, a bound LOOP, cmux/tmux/headless presentation, no automatic merge. Use to run several ready tasks in parallel — 'rodar várias tarefas em paralelo', 'lançar o fleet', 'fleet status', 'tear down member X'. Do NOT use for a single task (sdd-execute, sdd-loop) or for merging without the explicit teardown token.

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Design charts, metrics, and data tables that help users interpret and compare data. Use when the user asks to visualize data, choose chart types, improve dashboard analytics, or make data presentation accessible. Dashboard navigation and shell layout alone belong to add-ui or arrange.

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Design or improve search experiences, result presentation, and filtering interfaces. Use when the user asks to add search, redesign search results, improve findability, build autocomplete, add filters, or fix zero-results dead ends.

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Create any visual design using Adobe Express templates — including flyers, posters, banners, social media posts (Instagram stories, Facebook posts, LinkedIn graphics), business cards, invitations, greeting cards, resumes, cover letters, brochures, newsletters, certificates, presentations, YouTube thumbnails, email headers, logos, menus, labels, and more. Use this skill whenever the user wants to make, design, create, or build any visual — even if they just say "make me a flyer", "design a poster", "I need something for Instagram", "create an event invite", "make a business card", or any similar request. Also handles requests to find or browse templates, edit text/copy, change background colors, or animate a design. Access: 🔐 Signed-In required | Gen AI: ❌

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Premium brand-kit image generation skill for creating high-end brand-guidelines boards, logo systems, identity decks, and visual-world presentations. Trained for minimalist, cinematic, editorial, dark-tech, luxury, cultural, security, gaming, developer-tool, and consumer-app brand systems. Optimized for intentional logo concepting, refined composition, sparse typography, strong symbolic meaning, premium mockups, art-directed imagery, and flexible grid layouts.

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Use this skill when the user requests to generate, create, or make presentations (PPT/PPTX). Creates visually rich slides by generating images for each slide and composing them into a PowerPoint file.

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Generate PPTX presentations, DOCX documents, XLSX spreadsheets, and PDF reports from structured JSON input using PaperJSX.

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