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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Expert-level Windows batch file (.bat/.cmd) skill for writing, debugging, and maintaining CMD scripts. Use when asked to "create a batch file", "write a .bat script", "automate a Windows task", "CMD scripting", "batch automation", "scheduled task script", "Windows shell script", or when working with .bat/.cmd files in the workspace. Covers cmd.exe syntax, environment variables, control flow, string processing, error handling, and integration with system tools.

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MUST USE for building FastAPI/REST API applications with Aerospike database (aerospike-py Rust/PyO3 async client). Covers AsyncClient lifespan management, FastAPI Depends injection, aerospike_py exception-to-HTTP-status mapping (RecordNotFound→404, RecordExistsError→409, BackpressureError→503, AerospikeTimeoutError→504), POLICY_EXISTS_CREATE_ONLY/UPDATE_ONLY for CRUD semantics, NamedTuple attribute access (record.bins not tuple unpacking), client.ping() readiness probe, batch_read returning dict, batch_write with in_doubt retry signal, and global AerospikeError handler. Triggers on: FastAPI + Aerospike, REST API + aerospike-py, CRUD API with Aerospike, client.ping() health probe, batch_read/batch_write endpoint, web server/HTTP service backed by Aerospike NoSQL, uvicorn + Aerospike.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Spark, pandas, polars, DuckDB optimization for batch data processing. Activate on: batch processing, Spark optimization, polars, DuckDB, pandas performance, data frame, shuffle, partition, memory optimization. NOT for: streaming pipelines (use streaming-pipeline-architect), warehouse queries (use data-warehouse-optimizer).

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Batch-generate Dreamifly images/videos from prompt queues. Use when the user asks to batch-generate images, edit images with references, create text-to-video or image-to-video, validate or estimate Dreamifly job cost, retry failed media jobs, or summarize Dreamifly outputs.

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Offensive methodology for attacking GraphQL APIs during penetration tests and bug bounty engagements. Covers the full attack lifecycle: endpoint discovery, introspection abuse and blind schema reconstruction when introspection is disabled, authentication and authorization bypass through Relay node IDs and nested object traversal, injection via variables and directives, query batching for brute force and OTP bypass, denial of service through depth bombs and alias amplification, WebSocket subscription hijacking, information disclosure through verbose errors and field suggestion oracles, and file upload abuse via the multipart GraphQL specification. Includes tool-specific guidance for InQL, graphql-cop, CrackQL, BatchQL, Altair, GraphQL Voyager, and clairvoyance. Trigger on: GraphQL, graphql, introspection query, batching attack, query depth, GraphQL injection, GraphQL IDOR, field suggestion, GraphQL auth bypass, GraphQL DoS, GraphQL security, graphql-cop, InQL, CrackQL, BatchQL, Relay node, alias amplificat...

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用于设计和审查使用MyBatis的Java数据存取代码，检查查询结果与对象的映射、动态SQL和参数安全、事务、分页及批量更新，并排查慢查询和重复查询。

• 设计映射器与XML的对应关系
• 检查动态SQL和输入安全
• 检查多次更新的事务

设计生产数据库的结构与数据迁移，涵盖列和索引变更、分批补全数据、分阶段替换列及恢复计划，帮助规划大表更新和不中断服务的结构切换。

• 为大表添加列或索引
• 分阶段更改列名以避免停机
• 分批补全现有数据

Create HeyGen avatar videos with a chosen presenter, voice, exact script, and backgrounds for each scene. Use photos as presenters, generate transparent WebM files for compositing, or produce batches of videos with consistent specifications.

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• Have a chosen avatar read an exact script
• Create multiple scenes with different backgrounds
• Generate transparent WebM files for compositing

Run protein structure prediction, molecular design, and docking tools on Tamarind Bio without a local GPU. Guides tool selection, input validation, job submission, batch processing, and result retrieval through its REST API or MCP server.

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• Predicting protein structures in the cloud
• Running binder or antibody design tools
• Submitting batches of sequences for analysis

Convert PDF, Office, and other documents into Markdown that preserves useful text structure. Use batch conversion and literature organization to prepare files for search, text analysis, or AI systems that retrieve information from documents.

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• Convert PDF and Office files to Markdown
• Batch-convert a document folder
• Organize research papers with source metadata

Build Python workloads on Modal for cloud execution, including GPU model training and inference, web APIs, scheduled jobs, and parallel batch processing. Configure container environments, persistent storage, and automatic scaling through the Modal SDK.

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• Serving an AI model through a web API
• Running model training or fine-tuning on cloud GPUs
• Processing independent batch inputs in parallel

Generate candidate positions and orientations for small molecules binding to proteins with DiffDock and DiffDock-L. Prepare single or batch docking runs, organize predicted poses by model confidence, and review validation needs without treating confidence as binding affinity.

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• Predicting binding poses for a protein and small molecule
• Preparing and validating batch docking inputs
• Comparing poses across receptor conformations

Process DNA, RNA, and protein sequences with Biopython, convert biological files, and retrieve NCBI records. Supports batch workflows for sequence comparison, searches for similar sequences, protein structure analysis, and evolutionary trees.

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• Convert GenBank files to FASTA
• Calculate sequence length and GC content in batches
• Retrieve sequences and publication records from NCBI

Analyze 2D fluorescence microscopy images to detect nuclei and measure their counts, intensity, and area. Run repeatable CellProfiler batches, inspect nucleus outlines, and review measurement tables with recorded pipeline settings and quality checks.

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• Count nuclei across microscopy image batches
• Measure fluorescence intensity and area for each nucleus
• Inspect nucleus outlines for segmentation errors

Turn JSON or CSV data into Markdown notes using Knap templates. Apply formatting rules and conditional sections, generate files in batches, or shape web content extracted by Defuddle into a consistent note format.

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• Generate Markdown notes from JSON or CSV data
• Create multiple notes with a shared template
• Format Defuddle output into a note

Helps build Python workflows for translating Word, PDF, Excel, PowerPoint, and other documents while preserving formatting. Covers Azure batch translation, multiple target languages, terminology glossaries, and checks for job progress and document errors.

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• Translating batches of documents while preserving formatting
• Translating documents into multiple languages
• Applying a glossary for specialized terminology

Use Azure's Python transcription client to turn audio files into text and review timestamped results. Covers authentication, installed SDK options, and error handling, while clarifying when streaming or asynchronous batch work needs a different Speech API.

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• Transcribe a local recording with consent
• Review timestamped transcription output
• Check authentication and installed SDK options

Design scheduled AI workflows for document ingestion, batch processing, and model training using Prefect, Airflow, or Dagster. Compare orchestration tools and plan task dependencies, retries, caching, and monitoring through implementation fragments.

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• Schedule document ingestion and RAG index refreshes
• Design batch workflows for LLM requests
• Connect model training with quality evaluation

Implement Python error handling with early input checks, appropriate exception types, and clear messages. Handle individual failures in batch jobs, preserve error context for debugging, and use Pydantic models to validate structured input.

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• Validating user input and API parameters
• Designing exception types and clear error messages
• Continuing batch jobs after individual failures

Split a large goal into clearly bounded tasks that can run in parallel. Coordinate existing agent and worktree tools, then combine and verify the results. The skill starts only when explicitly requested.

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• Splitting a large goal into parallel tasks
• Coordinating work across multiple agents
• Running tasks in separate worktrees