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Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Use when work crosses into Apple's system surfaces rather than your own UI or data — Siri and Shortcuts, widgets, Live Activities, in-app purchase, localization, privacy prompts, alarms, timers, calendar, reminders, contacts, SharePlay, VoIP and CallKit, accessory pairing, weather, Spotlight indexing, background tasks, Background Assets, push, or push on networks with no internet.

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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.

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Cross-border selling on TikTok Shop. Market selection, logistics setup, localization strategy, compliance requirements, and international expansion. Use when the user asks about TikTok Shop international selling, cross-border ecommerce, global expansion, or selling in multiple countries.

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Build machine vision inspection systems with MATLAB Visual Inspection Toolbox. Covers the full arc from problem selection through deployment: anomaly detection (Student-Teacher, PatchCore, FastFlow, FCDD), object detection (YOLOX), counting (CounTR, shape matching), gauging and measurement (caliper, fitcircle, fitangle), blob analysis (regionprops, calibrated measurement), shape matching for fixturing and localization, synthetic data generation for training augmentation, and deployment to standalone apps, embedded C/C++, NVIDIA GPUs (TensorRT), NPUs (ONNX), and Beckhoff PLCs. Routes to rule-based tools when problems are geometric and deterministic, AI-based tools when defect appearance varies, and hybrid pipelines combining both.

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Generate driving scenes, scenarios, road surfaces, and 3D content from scenariobuilder.* sensor data (GPS, camera, lidar, actor tracks) using Scenario Builder for Automated Driving Toolbox. BUILD, EXPORT, or AUGMENT a virtual scenario/scene/map: ego or actor trajectories, trajectory smoothing, OpenCRG road-surface extraction, 3D asset generation, static-object placement, point-cloud georeferencing + elevation, lane-based ego localization, sensor-fusion tracking, scenario-event extraction (cut-ins, hard brakes, near-misses, ADAS disengagements), or export to RoadRunner, drivingScenario, OpenDRIVE, OpenCRG, OpenSCENARIO, or Unreal Engine. Also: log-to-scenario, scenario harvesting, accident/near-miss reconstruction, SOTIF (ISO 21448) and ISO 26262 scenario coverage, USGS-aerial-lidar augmentation, traffic-sign placement, vision-based vehicle classification for actor assets. NOT for raw-data import or multi-sensor sync/crop/offset/timestamp normalization — route those to matlab-import-driving-data.

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This skill should be used when the user asks to "verify UI changes", "test every screen and action", "run regression QA", "check a deployed UI", or "validate an extension release". Test known web and browser-extension workflows on localhost, staging, or production with action coverage, recovery, localization, accessibility, and real integration evidence. Use dogfood for open-ended bug discovery.

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MANDATORY for every coding agent and contributor touching localized content — keep all five localization surfaces (dashboard UI keys, wiki page, full mirrored guides, locale-aware formatting, language switchers) in parity across every supported language. Use automatically (without being asked) whenever you add or change user-visible UI copy, add an i18n key, edit README-EN.md or a localized guide, edit wiki/index.html, or add a language surface.

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Sync, validate, and apply App Store metadata and store assets with asc. Use when updating localizations, keywords, App Clip or preview assets, Asset Library media and placements, or migrating legacy fastlane metadata.

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Bulk-localize subscription, subscription-group, and in-app purchase display names across App Store locales using asc, including API 4.4.1 version-scoped v2 resources. Use when filling or updating subscription/IAP names and descriptions without App Store Connect UI work.

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Use when generating or editing video on Scenario via MCP: text-to-video, a music video from a song, image-to-video (still animation, frame anchors), motion prompting, lipsync and talking avatars, dubbing a clip, video upscale to 4K, prompt-based editing, trim, split, concat, extend, reframe, resize, background removal, frame or audio extraction, long video jobs, or a clip over a duration limit. Keywords: txt2video, img2video, video2video, audio2video, I2V, T2V, V2V, localization.

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Use when generating or transforming audio with ElevenLabs models on Scenario via MCP: text-to-speech with inline emotion tags, music from a prompt or sectioned songs, sound effects and loops, dubbing audio or video into another language, re-voicing a recording with a preset or cloned voice, or isolating speech from noise. Keywords: ElevenLabs, Eleven v3, Multilingual v2, Turbo 2.5, Music v2, Sound Effects 2, Dubbing, Voice Changer, Speech to Speech, Voice Isolator, TTS, SFX, localization.

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Use when generating or editing images with Ideogram models on Scenario via MCP: posters, logos, menus, packaging, or signage with exact in-image text, editing an image in place while keeping its exact size, transparent PNG generation, background removal that keeps hair and glass edges, editable text layers for localization, or one consistent character from a reference. Keywords: Ideogram 4.5, Precise Edit, V4, V3, typography, aspect ratio, layerize, character reference, inpainting.

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When the user wants a full-page metadata audit or implementation across discovery, search intent, title, description, canonical, robots, hreflang, Open Graph, Twitter Cards, code or CMS changes, build validation, rendered HTML, production verification, localization, or post-release observation. Also use for "metadata audit," "sitewide meta optimization," "metadata implementation," "meta robots," "hreflang," "viewport," or "charset." For an isolated title, description, heading, Open Graph, or Twitter Card task, use its specialist skill directly.

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Translate, transcreate, review, or maintain multilingual product and marketing content, including source locking, glossary decisions, language style, machine-assisted workflows, legal-content safeguards, QA, and source-change synchronization. Use localization-strategy for market scope, locale architecture, rollout, and production release planning.

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Plan and run a multi-language or multi-region site. Use this skill when adding new locales, choosing URL structure for languages (subfolders vs subdomains vs ccTLDs), implementing hreflang, planning translation workflow, handling currency and date formats, designing for RTL languages, or auditing a stalled internationalization rollout. Triggers on internationalization, i18n, localization, l10n, hreflang, multi-language, translation workflow, RTL, locale, ccTLD, subfolder vs subdomain, language switcher. Also triggers when international audiences underperform or translations are stale.

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United Arab Emirates Governance, Risk & Compliance advisor — a jurisdiction-first compliance router. In the UAE, WHERE an organization sits determines its law: mainland (Federal PDPL, Decree-Law 45/2021 — executive regulations still pending), DIFC (DP Law No. 5 of 2020 as amended 2025, with a private right of action), ADGM (DP Regulations 2021), CBUAE-licensed financial institutions (consumer-data residency, outsourcing approvals), healthcare (ICT Health Law data localization), and government/CNI (UAE IA Regulation, Cyber Security Council; Dubai ISR, ADHICS). Use for any UAE / Dubai / Abu Dhabi / Emirates compliance question: UAE data protection, DIFC or ADGM privacy, free-zone vs mainland obligations, health-data residency, CBUAE cyber and outsourcing rules, market entry ("expanding to the UAE"), breach notification, gap assessments, and mapping UAE requirements to ISO 27001 / NIST CSF / SOC 2. Trigger for any UAE privacy, cybersecurity, or regulatory question even if no framework is named.

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International market expansion strategy for scaling companies. Use when expanding to new countries, evaluating international markets, planning localization, building regional teams, or assessing regulatory requirements by region.

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Design, evaluate, implement, or review image and video generation connectors for Timeline Studio. Use when adding a provider plugin, extracting the generation plugin host or registry, or checking a connector against Timeline Studio's authentication, output, localization, and My assets contract. Do not use for ordinary video editing or Codex plugin packaging.

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Generate internationalization (i18n) infrastructure for multi-language support in iOS/macOS apps. Use when localizing for multiple languages, adopting String Catalogs (xcstrings), or supporting RTL languages.

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