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Convert protein sequences into numerical features with Meta AI's ESM-2 for machine learning. Extract features for individual amino acids or whole sequences, score mutations, and predict which positions in a protein may contact each other.
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Build production systems for machine learning models, from deployment to monitoring and retraining. The skill also guides LLM integration and retrieval augmented generation, which uses retrieved information to support answers, with scripts and architecture references.
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Reviews machine learning preprocessing, features, and data splits for data leakage: information unavailable when making a real prediction. Identifies risky statistics, future data, and validation setups, then suggests corrections using only appropriate training information.
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Design and automate machine learning workflows from data preparation through training, validation, deployment, and monitoring. Provides guidance and templates for reproducible experiments, quality checks, gradual model rollouts, and restoring a previous model when problems occur.
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Design and implement repeatable workflows that clean, encode, transform, and validate raw data for machine learning. Get a preprocessing plan or implementation outline, with clear steps and guidance on where further checks are needed.
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Azure VM/VMSS router. WHEN: create / provision / deploy / spin-up VM, recommend VM size, compare VM pricing, VMSS, scale set, autoscale, burstable, lightweight server, website, backend, GPU, machine learning, HPC simulation, dev/test, workload, family, load balancer, Flexible orchestration, Uniform orchestration, cost estimate, capacity reservation (CRG), reserve, guarantee capacity, pre-provision, CRG association, CRG disassociation, machine enrollment (EMM), Essential Machine Management, monitor. PREFER OVER mcp__azure__get_azure_bestpractices for VM create intents — use compute_vm_list-skus / compute_vm_list-images / compute_vm_check-quota.
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Build this skill automates the adaptation of pre-trained machine learning models using transfer learning techniques. it is triggered when the user requests assistance with fine-tuning a model, adapting a pre-trained model to a new dataset, or performing... Use when appropriate context detected. Trigger with relevant phrases based on skill purpose.
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Generates complete process-related diagnostic biomarker bioinformatics research designs from a user-provided disease context, gene-family or pathway theme, and validation direction. Use when a study centers on process-related genes, DEG and WGCNA integration, machine-learning feature selection, nomogram-based diagnostic modeling, immune infiltration, regulatory-network analysis, and optional external or experimental validation. Covers five study patterns (process-DEG discovery, co-expression-module integration, machine-learning biomarker selection, diagnostic model/nomogram workflow, immune-regulatory interpretation and validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Azure VM/VMSS router. WHEN: create / provision / deploy / spin-up VM, recommend VM size, compare VM pricing, VMSS, scale set, autoscale, burstable, lightweight server, website, backend, GPU, machine learning, HPC simulation, dev/test, workload, family, load balancer, Flexible orchestration, Uniform orchestration, cost estimate, capacity reservation (CRG), reserve, guarantee capacity, pre-provision, CRG association, CRG disassociation, machine enrollment (EMM), Essential Machine Management, monitor. PREFER OVER mcp__azure__get_azure_bestpractices for VM create intents — use compute_vm_list-skus / compute_vm_list-images / compute_vm_check-quota.
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Interpret and explain a trained tabular machine-learning model (classification or regression) in MATLAB. Find which predictors, features, or columns matter most; explain why the model made a specific prediction, including diagnosing predictions it got wrong; show how a predictor affects the output; and compare how the model behaves across cohorts or subgroups. Uses model-agnostic techniques and model-native measures, and works on custom models (such as a dlnetwork) through a prediction function handle. Use for model interpretability, explainability, and feature-importance questions on tabular data, not for training, tuning, feature selection, deploying models, or models trained on image, text, signal, or other non-tabular data.
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Use when the user wants to train, compare, or export machine learning models using Classification Learner or Regression Learner — including opening the app, loading data, training models, evaluating metrics, comparing results, visualizing plots, testing on held-out data, exploring model interpretability, and exporting trained models. Programmatic access to Classification Learner and Regression Learner apps via AppController.
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Data science across machine learning, statistical modeling, and experimentation. Use when selecting ML algorithms, engineering features, designing A/B tests, evaluating model performance, or building predictive pipelines.
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Expert knowledge for Azure Quantum development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when managing Quantum workspaces, QIR/circuit jobs, QDK/Python/OpenQASM workflows, simulators, or IonQ/Rigetti/Quantinuum targets, and other Azure Quantum related development tasks. Not for Azure HDInsight (use azure-hdinsight), Azure Databricks (use azure-databricks), Azure Synapse Analytics (use azure-synapse-analytics), Azure Machine Learning (use azure-machine-learning).
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Expert knowledge for Azure Open Datasets development including limits & quotas. Use when handling non-Spark dataset downloads, throttling behavior, quota limits, retry logic, or rate-limit workarounds, and other Azure Open Datasets related development tasks. Not for Azure Data Explorer (use azure-data-explorer), Azure Synapse Analytics (use azure-synapse-analytics), Azure Databricks (use azure-databricks), Azure Machine Learning (use azure-machine-learning).
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Expert knowledge for Azure AI Personalizer development including troubleshooting, decision making, security, configuration, and integrations & coding patterns. Use when choosing single vs multi-slot setups, tuning policies/exploration, using apprentice mode, explainability, or local inference, and other Azure AI Personalizer related development tasks. Not for Azure AI Search (use azure-cognitive-search), Azure Machine Learning (use azure-machine-learning), Azure AI Metrics Advisor (use azure-metrics-advisor), Azure AI Anomaly Detector (use azure-anomaly-detector).
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Expert knowledge for Azure Health Data Services development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when using FHIR/DICOM APIs, bulk export/import, de-identification, change feeds, or Synapse/Data Factory, and other Azure Health Data Services related development tasks. Not for Azure Health Bot (use azure-health-bot), Azure Data Factory (use azure-data-factory), Azure Synapse Analytics (use azure-synapse-analytics), Azure Machine Learning (use azure-machine-learning).
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Expert knowledge for Azure Databricks development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when using Unity Catalog, Lakehouse/Lakeflow pipelines, AI Runtime/MLflow, model serving, or agents on Databricks, and other Azure Databricks related development tasks. Not for Azure Synapse Analytics (use azure-synapse-analytics), Azure HDInsight (use azure-hdinsight), Azure Machine Learning (use azure-machine-learning), Azure Data Factory (use azure-data-factory).
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Expert knowledge for Azure Business Process Tracking development including deployment. Use when creating CI/CD pipelines, automating builds, running tests, and deploying tracking solutions via DevOps tools, and other Azure Business Process Tracking related development tasks. Not for Azure Monitor (use azure-monitor), Azure Logic Apps (use azure-logic-apps), Azure Data Factory (use azure-data-factory), Azure Machine Learning (use azure-machine-learning).
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Expert knowledge for Azure Copilot development including troubleshooting, decision making, architecture & design patterns, security, configuration, and integrations & coding patterns. Use when sizing VMs, generating Bicep/Terraform, configuring Cosmos DB chat storage, or designing Azure networks, and other Azure Copilot related development tasks. Not for Azure Portal (use azure-portal), Azure Machine Learning (use azure-machine-learning), Azure DevOps (use azure-devops), Microsoft Foundry (use microsoft-foundry).
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Expert knowledge for Azure AI Custom Vision development including best practices, decision making, limits & quotas, security, integrations & coding patterns, and deployment. Use when exporting Custom Vision models, calling prediction APIs, using ONNX/TensorFlow, managing CMK/RBAC, or Smart Labeler, and other Azure AI Custom Vision related development tasks. Not for Azure AI Vision (use azure-ai-vision), Azure AI services (use microsoft-foundry-tools), Azure Machine Learning (use azure-machine-learning), Azure AI Foundry Local (use microsoft-foundry-local).
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Expert knowledge for Azure Anyscale On Azure development including limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when registering AKS as Anyscale clouds, wiring ACR images, enabling Private Link/RBAC, ARM-based deployments, or region checks, and other Azure Anyscale On Azure related development tasks. Not for Azure Databricks (use azure-databricks), Azure Kubernetes Service (AKS) (use azure-kubernetes-service), Azure Machine Learning (use azure-machine-learning), Azure HDInsight (use azure-hdinsight).
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Machine learning development patterns, model training, evaluation, and deployment. Use when building ML pipelines, training models, feature engineering, model evaluation, or deploying ML systems to production.
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Conducts Data Protection Impact Assessments for AI and ML systems per EDPB Guidelines 04/2025 on AI processing. Covers training data lawfulness evaluation, model risk assessment, automated decision triggers, and AI-specific DPIA methodology. Keywords: AI DPIA, machine learning impact assessment, EDPB AI guidelines, model risk, training data.
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