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Quality metrics for IMC data including signal-to-noise, channel correlation, tissue integrity, and acquisition QC. Use when assessing data quality before analysis or troubleshooting problematic acquisitions.
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Quality control for pooled CRISPR screens. Covers library representation, read distribution, replicate correlation, and essential gene recovery. Use when assessing screen quality before hit calling or diagnosing poor screen performance.
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ChIP-seq quality control metrics including FRiP (Fraction of Reads in Peaks), cross-correlation analysis (NSC/RSC), library complexity, and IDR (Irreproducibility Discovery Rate) for replicate concordance. Use to assess experiment quality before downstream analysis. Use when assessing ChIP-seq data quality metrics.
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Statistical arbitrage tool for identifying and analyzing pair trading opportunities. Detects cointegrated stock pairs within sectors, analyzes spread behavior, calculates z-scores, and provides entry/exit recommendations for market-neutral strategies. Use when user requests pair trading opportunities, statistical arbitrage screening, mean-reversion strategies, or market-neutral portfolio construction. Supports correlation analysis, cointegration testing, and spread backtesting.
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Use when the user asks to "figure out where our direct traffic really comes from", "measure dark social", "add a how-did-you-hear-about-us field", or "show social drives signups without click data"; produces a share-link/UTM hygiene spec for owned share surfaces, a self-reported attribution field design that replaces an existing form field (free-text first, coded later), a GA4 direct-traffic decomposition read (deep-URL directs, mobile-app skew, private-push correlation) with every derived number hard-labeled Estimated/proxy, and a branded-search-lift proxy from GSC plus Wikipedia pageviews — the declared dark-social method behind ECHO O2. Not for paid-channel attribution reconciliation (platform-claimed vs analytics conversions) — use attribution-reconciler. 暗社交归因/直接流量分解/自报来源字段/分享链路UTM
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Authors, validates, and troubleshoots AWS CloudFormation templates. Covers template authoring with secure defaults, local validation with either cfn-lint or cloudformation-validate, cfn-guard security and compliance checks as a recommended default, account-aware CloudFormation service pre-deployment validation, CloudFormation Express mode for faster deployments, and root-cause diagnosis of failed stacks using CloudFormation events and CloudTrail correlation. Also covers author-time template intelligence with the CloudFormation Language Server and published cloudformation-validate libraries.
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Instrument Adobe integrations with redacted structured logs, request/job/activation correlation, service-level indicators, alerts, and evidence retention. Use when the task requires adobe content-safe observability. Trigger with "monitor Adobe API", "Adobe observability", or "App Builder logs".
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Org-grade attack-surface mapping: given a company's legal identity, discover its ENTIRE owned internet footprint — corporate family -> owned domains -> owned netblocks/ASN -> live assets — with attribution discipline, not just DNS breadth. The org-first attribution pyramid (legal entity -> LEI/registration -> corporate family -> owned domains -> owned netblocks/ASN -> live assets). Corporate-identity resolution via the GLEIF LEI API (legal name -> LEI, exact-LEI direct-children expansion, downward-only depth-capped BFS, NEVER a name re-resolution), SEC-EDGAR full-text search + Exhibit-21 subsidiary entity names, OpenCorporates entity corroboration, Wikidata SPARQL corporate graph (P856/P355/P749/P1830). Domain attribution via reverse-WHOIS (WhoisXML preview-then-purchase quota guard, SecurityTrails associated-domains — both paid), crt.sh O= certificate-transparency organization pivot (keyless), infrastructure correlation (shared NS/MX/SaaS-TXT, netblock membership, reverse-DNS PTR), and the independent-evidence combiner (1-prod(1-w_i), rule of three, OwnerTier NONE/WEAK/MODERATE/STRONG/CONFIRMED) — discover-only `related:` candidates are NEVER auto-scanned. Netblock/ASN attribution via org-first RIR queries (ARIN Whois-RWS org-handle search, RIPE DB organisation + inverse-org search) that recover 'dark netblocks' with no DNS link to the seed, ASN discovery (RIPEstat + BGPView union), the HYPERSCALER-SCOPE GUARD (never attribute a whole AWS/GCP/Azure/Cloudflare announced range to a tenant — keep only the seed-containing block, tag shared_hosting_cdn), and org-identity-seeded internet-scan-index queries (Shodan/Censys/ZoomEye/FOFA/BinaryEdge org: filters + an always-on keyless crt.sh fallback). Promote-to-scan triage ranks forgotten discover-only netblocks by remote-access exposure (gateway-vendor/KEV/control-plane/datastore port scoring) into an operator queue. Attribution confidence rubric + anti-patterns (namesake grafting via GLEIF name re-resolution, single-signal ownership, hyperscaler over-attribution, privacy-WHOIS pivot poisoning, RIR org-name collisions). Passive/keyless-first OSINT only — every paid-key dependency is enrichment on top of a keyless core, never a hard requirement. Use when mapping an organization's full corporate-family internet footprint, resolving a legal entity to its LEI/subsidiaries, discovering domains/netblocks/ASNs an org owns beyond its one seed domain, auditing M&A/shadow-IT sprawl, or scoping an engagement that starts from a company NAME rather than a domain.
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Comprehensive OSINT methodology for external red-team operations and authorized attack-surface assessments. Covers the 6-stage recon pipeline (seed → asset expansion → enrichment → exposure analysis → convergence → operator-armed active validation) with connector-resilience and stage-vs-gating discipline, asset-graph discipline, severity rubric, confidence upgrade workflows, time budgeting, identity-fabric mapping, breach×identity correlation with per-person identity dossiers, detectability tagging, detection-aware probing, WAF/CDN bypass, vulnerability prioritization, phishing infrastructure planning, bug bounty submission, and client deliverable templates. Use when planning or executing reconnaissance against authorized targets, mapping an organization's external attack surface, investigating a person/entity, or producing client deliverables.
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Build a dense, data-heavy screen - an analytics console or a trading terminal - with real charts drawn from tokens: candlestick, volume, depth, stacked area, waterfall, scatter, correlation matrix, donut, gauge, sparklines, heatmaps and order books. Use when the request is a dashboard, terminal, monitoring view, data console, or any screen whose job is to show many numbers at once. Covers the layout sequence, the SVG geometry, the accessibility contract per chart type, and the contrast traps that only appear in dark mode.
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NGS analysis toolkit. Used for BAM to bigWig conversion, quality control (correlation, PCA, fingerprint plots), heatmaps/feature plots (TSS, peaks), suitable for ChIP-seq, RNA-seq, ATAC-seq visualization.
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Perform statistical tests, hypothesis testing, correlation analysis, and multiple testing corrections using scipy and statsmodels. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
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Verifies whether a scientific or biomedical claim is actually supported by the cited original papers rather than by citation drift, overstatement, selective citation, or correlation-to-causation inflation. Use this skill whenever a user wants to check whether a repeated statement, slide claim, manuscript sentence, review assertion, or “people often say” scientific conclusion is truly supported by the underlying primary literature. Always separate the claim itself, the cited paper(s), what the paper actually showed, what it did not show, and whether later retellings drifted beyond the original evidence. Never fabricate references, findings, study features, or citation chains.
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Quantum mechanics simulations and analysis using QuTiP (Quantum Toolbox in Python). Use when working with quantum systems including: (1) quantum states (kets, bras, density matrices), (2) quantum operators and gates, (3) time evolution and dynamics (Schrödinger, master equations, Monte Carlo), (4) open quantum systems with dissipation, (5) quantum measurements and entanglement, (6) visualization (Bloch sphere, Wigner functions), (7) steady states and correlation functions, or (8) advanced methods (Floquet theory, HEOM, stochastic solvers). Handles both closed and open quantum systems across various domains including quantum optics, quantum computing, and condensed matter physics.
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Tools and techniques for detrending time series data in macroeconomic analysis. Use when working with economic time series that need to be decomposed into trend and cyclical components. Covers HP filter, log transformations for growth series, and correlation analysis of business cycles.
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Root cause analysis frameworks including log-first investigation, git bisect correlation, and pattern-based diagnosis with confidence scoring.
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Lightweight outcome tagging for meetings — won, lost, stalled, great, or noise. Use whenever the user says "tag this meeting", "mark that as a win", "that one was a loss", "tag yesterday's call as stalled", "mark this great", "that meeting was noise", "label that meeting", or any time they describe a meeting outcome in passing. Tagging takes 5 seconds and unlocks /minutes-mirror correlation analysis — the more meetings get tagged, the smarter mirror gets at telling the user what behavior patterns lead to wins. Surface this skill any time the user mentions a meeting result, win, loss, or wasted time.
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Intelligent interaction performance analysis with automated workflows for INP debugging, scroll jank investigation, and main thread blocking. Includes decision trees that automatically run script attribution when long frames detected, break down input latency phases, and correlate layout shifts with interactions. Features workflows for complete interaction audit, third-party script impact analysis, and animation performance debugging. Cross-skill integration with Core Web Vitals (INP/CLS correlation) and Loading (script execution analysis). Use when the user asks about slow interactions, janky scrolling, unresponsive pages, or INP optimization. Compatible with Chrome DevTools MCP.
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Use when building or cleaning the tables and figures for an Academy of Management Journal (AMJ) manuscript — correlation tables, regression/SEM/HLM result tables, the theoretical-model figure, and interaction plots in AOM house style. Finalizes exhibits; it does not run the analysis (amj-data-analysis) or frame the contribution (amj-contribution-framing).
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Manage Fabric Warehouse, Lakehouse SQL endpoints, and Mirrored Databases: DDL/DML, COPY INTO, read-only T-SQL, Query Insights diagnostics, and Capacity Metrics CU-spike correlation. Synapse migration target SQL belongs to synapse-migration; Fabric SQL database belongs to sqldb-cli. Triggers: query warehouse, create warehouse table, failed or canceled query, CU spike, Capacity Metrics app, custom SQL pool, Lakehouse table health.
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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
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Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.
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Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for visualisation.
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