“databases”的搜索结果

Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.

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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

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Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.

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Use Neon serverless Postgres with branching, connection pooling, and instant scalability for modern applications with Prisma or Drizzle ORM integration. Use when setting up serverless Postgres databases, implementing database branching for preview environments, configuring connection pooling, optimizing for serverless cold starts, using Prisma with Neon, implementing database migrations, scaling databases automatically, or building applications on Vercel/Netlify with Postgres.

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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.

中文简介正在准备中。当前显示原文说明。

Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.

中文简介正在准备中。当前显示原文说明。

Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

中文简介正在准备中。当前显示原文说明。

Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Expert database administrator specializing in modern cloud databases, automation, and reliability engineering. Masters AWS/Azure/GCP database services, Infrastructure as Code, high availability, disaster recovery, performance optimization, and compliance. Handles multi-cloud strategies, container databases, and cost optimization. Use PROACTIVELY for database architecture, operations, or reliability engineering.

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检查Perl代码中的输入处理、文件操作、外部命令、SQL及网页输出，依据具体示例和检查清单识别不安全写法，并调整为更安全的实现。

• 检查Perl输入验证
• 检查文件操作与命令执行
• 防范DBI查询中的SQL注入

使用gget查询基因信息、获取核苷酸和氨基酸序列，搜索相似序列并探索基因集的功能及疾病关联，同时保存结果和查询条件，便于日后核查研究记录。

• 查询基因ID与转录本信息
• 获取核苷酸和氨基酸序列
• 使用BLAST或BLAT进行小规模搜索

将文档、会话和项目信息分类保存到合适的位置，跨本地文件、记忆工具、知识库和数据库查重、同步与检索，并维护索引和摘要。

• 将文档和会话保存到知识库
• 整理重复笔记
• 同步多个存储位置的知识

将业务逻辑与数据库、外部 API 和框架分离，整理清晰的边界、用例及测试，支持新服务设计，也支持按功能逐步改造已有代码。

• 分离业务规则与数据库及 API 调用
• 在 HTTP、CLI 和队列间共用流程
• 保留业务规则并替换外部基础设施

使用 Flox 将开发工具、数据库、版本及配置集中到文件中，建立可在 macOS 和 Linux 上复现的开发环境，并与团队共享或为智能体添加项目工具。

• 统一团队的开发环境
• 管理语言工具与系统依赖
• 在本地启动 PostgreSQL 和 Redis

将技术或设计选择的理由记录为带编号的 Markdown 文件，整理背景、备选方案及影响，并维护索引。也可查阅已有设计决策记录，解释过去的选择。

• 记录框架或数据库的选型理由
• 整理设计备选方案及利弊
• 查找过去技术决策的原因

在Claude Code中设计多名专业代理协作的工作流程，将进度、决策和日志保存到文件，以便跨会话继续工作，并把重复任务整理为可复用命令和定期执行计划。

• 协调开发、写作和调研分工
• 跨会话保留项目背景
• 定期执行晨间状态检查

通过公开数据库查询化合物活性、分子性质和药物相互作用，整理候选口服药物的分子特征及基因与疾病的关联，为药物研发的前期调研提供支持。

• 查找针对特定靶点的活性化合物
• 评估候选口服药物的分子性质
• 调查相互作用和不良事件报告

通过Stripe Projects为项目配置数据库、短信等外部服务，将凭据同步至`.env`，并统一管理服务密钥更新、套餐变更及服务移除。

• 为项目配置Neon Postgres
• 为应用添加短信服务
• 同步凭据并更新服务密钥

无需准备额外训练数据，即可用文字标签对图片分类，或按内容描述搜索图片。还支持比较图片与文字的相似度、批量处理，以及将数值表示存入向量数据库。

• 用文字标签对照片分类
• 按内容描述搜索图片
• 比较图片与说明文字的对应程度

将API、数据库和文件处理实现为AI代理可调用的MCP服务器，支持用Python定义工具、本地验证、客户端注册及通过HTTP对外提供服务。

• 让AI代理调用现有API
• 提供SQLite只读查询
• 将文本文件检查与搜索封装为工具

先准备可重复复现症状的测试或命令，再按原因调查、正常示例对比、假设验证和修复四个阶段，定位根本原因并用回归测试验证结果。

• 调查测试或构建失败
• 排查跨多个系统的异常
• 复现间歇性缺陷

通过测量定位页面显示、交互、API和数据库的性能瓶颈，对比修改前后的数据验证效果。撤销没有明确收益的修改，并添加性能检查与监控，防止再次变慢。

• 调查页面加载和交互迟缓的原因
• 减少API延迟与重复查询
• 检查修改后的性能下降

Connect Claude to external apps through Composio to send emails, create issues, post messages, and update data. It also supports linked tasks, such as summarizing GitHub issues and posting the results to Slack.

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• Send an email through Gmail
• Create a GitHub issue with a label
• Post a deployment update to Slack