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Predict B-cell and T-cell epitopes for vaccine antigen design and epitope mapping with BepiPred-3.0, DiscoTope-3.0, the IEDB tools, and EL-mode MHC presentation. Encodes the load-bearing asymmetry that T-cell epitope prediction is mature (it reduces to MHC presentation, AUC>0.9) while B-cell prediction is unreliable (linear predictors ~AUC 0.6 because ~90% of real epitopes are conformational) — so structure-based DiscoTope-3.0 on AlphaFold models is the only defensible B-cell path, propensity scales are obsolete, and NetChop is largely redundant on EL-trained models. Use when mapping epitopes or selecting vaccine antigens. MHC binding lives in mhc-binding-prediction.

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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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High-performance DataFrame operations for large-scale data analysis

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Parallel and distributed computing for large-scale data processing

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GDPR Data Protection Impact Assessment (DPIA) guidance under Article 35 GDPR, EDPB Guidelines WP 248 rev.01, EDPB Opinion 28/2024 (AI), and national SA blacklists/whitelists. Triggers: "DPIA", "DSFA", "Datenschutz-Folgenabschätzung", "impact assessment", "Art. 35", "do I need a DPIA", descriptions of new high-risk processing (profiling, AI, biometrics, large-scale monitoring, special category data), Art. 36 prior consultation questions, national blacklist/whitelist queries.

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Expert blueprint for Battle Royale games including shrinking zone/storm mechanics (phase-based, damage scaling), large-scale networking (relevancy, tick rate optimization), deployment systems (plane, freefall, parachute), loot spawning (weighted tables, rarity), and performance optimization (LOD, occlusion culling, object pooling). Use for multiplayer survival games or last-one-standing formats. Trigger keywords: battle_royale, zone_shrink, storm_damage, deployment_system, loot_spawn, networking_optimization, relevancy_system, snapshot_interpolation.

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Expert blueprint for Battle Royale games including shrinking zone/storm mechanics (phase-based, damage scaling), large-scale networking (relevancy, tick rate optimization), deployment systems (plane, freefall, parachute), loot spawning (weighted tables, rarity), and performance optimization (LOD, occlusion culling, object pooling). Use for multiplayer survival games or last-one-standing formats. Trigger keywords: battle_royale, zone_shrink, storm_damage, deployment_system, loot_spawn, networking_optimization, relevancy_system, snapshot_interpolation.

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Spatially-aware quality control (QC) software for both spot-level and artifact-level QC in spot-based spatial transcripomics, such as 10x Visium. These methods calculate local (nearest-neighbors) mean and variance of standard QC metrics (library size, unique genes, and mitochondrial percentage) to identify outliers spot and large technical artifacts. Scales linearly with the number of spots and is designed to be used with 'SpatialExperiment' objects.

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Run a large-scale language migration with the six-step process: create the map and the rules, stress-test the rules, translate everything, compile, run it, match behavior. Use when the user wants to migrate, port, or rewrite a codebase from one language to another ("migrate this to Rust", "port our Python CLI to TypeScript", "should we rewrite this in Go?"), or asks for a migration feasibility assessment. Not for incremental JS→TS adoption — that needs no machinery — or single-file conversions.

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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

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Parallel/distributed computing for larger-than-RAM data. Components: DataFrames (parallel pandas), Arrays (parallel NumPy), Bags, Futures, Schedulers. Scales laptop to HPC cluster. For single-machine speed use polars; for out-of-core without cluster use vaex.

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Analyze large-scale construction datasets. Process thousands of projects for patterns, benchmarks, and predictive insights.

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Delegates tasks to Meta's Muse Code CLI (muse) via delegation-core. Use when delegation-core selects Muse or repository-scale work needs a 1M-token context.

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Use DIG (Dive into Graphs) to load graph-learning datasets, run graph generation, self-supervised learning, GNN explainability, 3D graph learning, GOOD OOD datasets, graph augmentation, fair graph learning, and large-scale graph workflows.

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Use AReaL for large-scale asynchronous LLM reinforcement learning, agentic RL, distributed post-training, inference/agent services, backend planning, and customization workflows.

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Create, iterate, and scale paid ad creative for Google Ads, Meta, LinkedIn, TikTok, and similar platforms. Use when generating headlines, descriptions, primary text, or large sets of ad variations for testing and performance optimization.

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Guides DPIA for biometric processing systems including facial recognition, fingerprint, voice, iris, and gait analysis. Covers Art. 9 special category requirements, Art. 35(3)(b) mandatory DPIA triggers for large-scale biometric processing, and EDPB Guidelines 3/2019 on video surveillance. Keywords: biometric, facial recognition, fingerprint, DPIA, Art. 9, special category, EDPB Guidelines 3/2019.

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Create original short videos using the 冲击后揭示｜从私密困境到城市尺度真因 Creative DNA for MiniMax H3 or Seedance 2.0. Use when the user wants this causal, camera, motion, rhythm, or payoff structure with new subjects and surfaces.

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Applies the engineering and research philosophies of Jeff Dean, Chief Scientist at Google DeepMind and Google Research. Reach for this skill whenever you are designing large-scale distributed systems, optimizing latency and energy efficiency, or making architectural decisions about machine learning infrastructure. It should trigger automatically for topics involving hardware-ML co-design, model distillation, sparse activation, massively multi-task models, or scaling systems by 5x to 10x. Use this skill to evaluate system bottlenecks, transition from specialized to unified models, and optimize experimental velocity. Apply his mental models to avoid premature 100x scaling and to treat AI models as reasoning engines rather than memorization databases.

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Intelligent code refactoring using IDE-level tools (rename, find-references, go-to-definition), AST-aware pattern matching, and TDD verification. Use for safe, large-scale refactoring with precision.

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Generate concise summaries of source code at multiple scales. Use when users ask to summarize, explain, or understand code - whether it's a single function, a class, a module, or an entire codebase. Handles function-level code by explaining intention and core logic, and large codebases by providing high-level overviews with drill-down capabilities for specific modules.

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Standardize a 2D animation baseline image with `/img2mo-std xxx.png/pos`. Use when preparing a character, creature, prop, or weapon baseline before motion generation, especially if the source image is too large, tightly cropped, lacks transparent action margin, has a white background, or later walk/attack/idle frames show clipping, overlap, scale popping, or inconsistent character size.

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Review the working-tree changes (vs main) for correctness, concurrency, architecture, testing, and API/doc issues — following .github/CODE_REVIEW.md — and return a severity-graded report. Scales the machinery to the diff size: a single code-reviewer agent for a small change, or a fan-out-and-verify Workflow for a large/multi-unit one. Produces findings; it does not apply fixes (the caller does).

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BigCommerce is a hosted e-commerce platform with REST and GraphQL APIs for headless storefronts. Use when a user asks to set up a large-scale online store, build a headless store with the Storefront GraphQL API or the Catalyst Next.js storefront, manage products and orders through the REST API, or migrate from Shopify to a more API-friendly platform.

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