“validation”的搜索结果

Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.

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Designs complete single-cell research plans from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a single-cell study — including disease-focused, mechanism-focused, biomarker-focused, translational, perturbation-inspired, or validation-aware projects. It should define the research question, choose the best-fit study pattern, recommend sample grouping logic, suggest reference datasets as examples only, specify the core analysis modules, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, sample metadata, accession numbers, cohort availability, cell-type labels, external validation resources, or literature references. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Generates complete conventional single-gene oncology research designs from a user-provided cancer context, target gene, and validation direction. Use when a study centers on a fixed candidate gene and needs expression, prognosis, clinicopathologic association, functional interpretation, immune context, genomic or epigenetic context, optional drug-response hypotheses, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Use this skill to migrate identified PostgreSQL tables to Timescale/TimescaleDB hypertables with optimal configuration and validation. **Trigger when user asks to:** - Migrate or convert PostgreSQL tables to hypertables - Execute hypertable migration with minimal downtime - Plan blue-green migration for large tables - Validate hypertable migration success - Configure compression after migration **Prerequisites:** Tables already identified as candidates (use find-hypertable-candidates first if needed) **Keywords:** migrate to hypertable, convert table, Timescale, TimescaleDB, blue-green migration, in-place conversion, create_hypertable, migration validation, compression setup Step-by-step migration planning including: partition column selection, chunk interval calculation, PK/constraint handling, migration execution (in-place vs blue-green), and performance validation queries.

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DataOps and DS/MLOps testing reference for data tiering, Bronze-to-Silver validation placement, pipeline invariants, pytest categories, and validation-versus-drift. Use when designing, reviewing, or generating data pipelines, transformation code, data validation, or data-science test suites.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Validation-first design for Cavekit — every kit requirement must be automatically verifiable. Six-gate validation pipeline, phase gates, merge protocol, completion signals, acceptance criteria patterns. Use when designing acceptance criteria, wiring CI gates, or debugging why an agent is producing output that nobody can verify.

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Builds form components and data collection interfaces including contact forms, registration flows, checkout processes, surveys, and settings pages. Includes 50+ input types, validation strategies, accessibility patterns (WCAG 2.1), multi-step wizards, and UX best practices. Provides decision trees from data type to component selection, validation timing guidance, and error handling patterns. Use when creating forms, collecting user input, building surveys, implementing validation, designing multi-step workflows, or ensuring form accessibility.

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Use when you need to design, review, or improve REST APIs with Micronaut — including @Controller routes, HTTP status codes, DTOs, Bean Validation, exception handlers, pagination, idempotency, ETag/If-Match, caching headers, versioning, contract-first OpenAPI (OpenAPI Generator), optional runtime OpenAPI via micronaut-openapi, and security annotations. This should trigger for requests such as Review or improve Micronaut @Controller REST APIs; Add validation, error handling, or align controllers with the OpenAPI contract on Micronaut HTTP layer; Design Micronaut controllers and DTO validation; Add Micronaut exception handlers and Problem Details responses; Improve pagination filtering or OpenAPI alignment in Micronaut APIs. Part of Plinth Toolkit

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Walk-forward validation framework for trading strategies and ML models with time-series-aware splits, overfit detection, and regime-aware validation

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Define database models with clear naming, appropriate data types, constraints, relationships, and validation at multiple layers. Use this skill when creating or modifying database model files, ORM classes, schema definitions, or data model relationships. Apply when working with model files (e.g., models.py, models/, ActiveRecord classes, Prisma schema, Sequelize models), defining table structures, setting up foreign keys and relationships, configuring cascade behaviors, implementing model validations, adding timestamps, or working with database constraints (NOT NULL, UNIQUE, foreign keys). Use for any task involving data integrity enforcement, relationship definitions, or model-level data validation.

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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

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Build validation rules for construction data. Create RegEx and logic-based validation for BIM elements, cost codes, and schedule data.

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Build automated BIM validation pipelines for IFC/Revit data. Continuous validation against IDS, LOD requirements, COBie, and project-specific BEP standards.

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Use the OpenConstructionERP validation engine: rule packs (BOQ quality, DIN 276, NRM, GAEB, MasterFormat, DPGF) that check estimates at import time and on demand. Use when verifying BOQ correctness or writing custom validation rules.

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AlphaFold2 / AlphaFold-Multimer structure prediction for validation and confidence scoring. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm2-sequence-scoring. For QC thresholds, use protein-design-qc.

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Test REST and GraphQL APIs with Playwright APIRequestContext, Supertest, or standalone HTTP clients. Covers schema validation with Zod 4/AJV, auth flow testing, CRUD lifecycle tests, error and header validation, pagination, and performance assertions. Use when: "API test," "endpoint test," "REST test," "GraphQL test," "schema validation," "Postman replacement." Not for: consumer-driven contract verification (Pact, broker) — use contract-testing; browser UI flows — use playwright-automation. Related: contract-testing, test-data-management, ci-cd-integration, playwright-automation.

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Testing strategies for MCP servers including unit tests, integration tests, schema validation, and security testingUse when "mcp testing, test mcp server, mcp inspector, mcp validation, mcp, testing, unit-testing, integration-testing, schema-validation" mentioned.

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World-class caching strategies - cache invalidation, Redis patterns, CDN caching, and the battle scars from cache bugs that served stale data for hoursUse when "cache, caching, redis, memcached, cdn, ttl, invalidation, stale, cache aside, write through, cache stampede, thundering herd, cache warming, etag, cache-control, caching, redis, memcached, cdn, performance, http-cache, ttl, invalidation" mentioned.

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独立开发者与微型 SaaS — 单人或极小团队 (≤3 人) 构建可持续订阅收入的软件产品商业, 有别于自由职业/咨询、企业级 SaaS 和开源维护: (a) 产品发现与验证 (自己的痒 vs 市场优先 Nugent/Walling; 着陆页冒烟测试; 先接 Stripe 再写代码; JTBD 访谈适配独立开发者场景; Reddit/HN/X/社区痛点挖掘; Mom Test 验证框架; 公开构建作为验证机制); (b) 独立开发者技术架构 (无聊技术论 McKinley; 单体优先; serverless vs VPS 在 ≤$100/月预算下的取舍; Rails/Django/Laravel/Next.js 等框架的出货速度选型; 托管服务优先于自建; Supabase/PlanetScale/Neon 数据库即服务; Clerk/Auth0 认证即服务; Stripe/Paddle/LemonSqueezy 支付; Vercel/Fly.io/Railway 部署; AI 辅助编码 Cursor/Copilot 作为力量倍增器); (c) 无营销团队的分发与增长 (SEO 作为微型 SaaS 护城河; Product Hunt 发布; AppSumo 终身授权利弊; 冷邮件; Twitter/X 公开构建; IndieHackers 社区分发; 集成市场 Shopify/WordPress/Zapier/Slack 应用目录; 联盟计划; 一人内容营销); (d) 定价与变现 (SaaS 定价心理学; freemium vs 免费试用 vs 纯付费; 按席位 vs 按用量 vs 固定费率; 年付折扣; 老用户保价; 微型 SaaS 流失率控制; MRR/ARR/LTV/CAC 在微型规模的含义; $10K MRR 里程碑心理学); (e) 独立创始人心智模型与生活设计 (default alive vs default dead Graham; 拉面盈利 Levels; 生活方式生意 vs 增长生意的光谱; 独立开发者倦怠预防; 时间管理与上下文切换成本; 地理套利与远程优先; 一次构建反复销售的资产思维; 社区作为支持网络 IndieHackers/WIP/MicroConf); (f) 法务与运营基础 (公司注册地选择 LLC/Ltd/GmbH 税效; Stripe Atlas vs Firstbase vs 本地律师; 服务条款与隐私政策; GDPR/CCPA 低成本合规; 知识产权基础; 首次雇人的承包商 vs 员工选择; 独立开发者会计 SaaS — Xero/QuickBooks; 多辖区税务义务)。中国独立开发者生态: 出海作为主导策略 (从中国构建面向全球市场的产品以避开国内竞争/监管); 即刻/V2EX/少数派作为社区枢纽; 微信小程序作为替代分发; 小报童/爱发电作为中文市场变现; 人民币定价心理学; 支付宝/微信支付集成; ICP 备案要求; 中国区 App Store 审核差异; 独立开发者周刊。诚实处理: 生存偏差 (每一个 Pieter Levels 背后是数千个从未达到 $1K MRR 的人), AI 对微型 SaaS 生态位的颠覆 (wrapper 产品脆弱), 独自构建的孤独与心理健康成本, 公开构建的表演性质 vs 真正透明, AppSumo 终身授权上瘾毁坏单位经济, 样板代码销售的伦理边界。不含: 企业级 SaaS (不同 GTM/销售/融资模型), 不含: 自由职业/咨询 (用时间换钱非建资产), 不含: 开源维护 (不同可持续性模型), 不含: 风投支持的创业 (不同增长期望), 不含: 无代码/低代码平台构建 (相邻但不同受众), 不含: 内容创作作为主业。 (Independent Developer and Micro-SaaS — the craft of single-person or tiny-team (≤3 people) software product businesses that generate sustainable recurring revenue without venture capital, distinct from freelancing/consulting, enterprise SaaS, and open-source maintainership: (a) product discovery and validation (scratching your own itch vs market-first Nugent/Walling; landing page smoke tests; Stripe checkout before code; Jobs-to-Be-Done interview adapted to solo context; Reddit/HN/X/community pain-point mining; idea validation frameworks Fitzpatrick Mom Test; build-in-public as validation mechanism); (b) technical architecture for solo operators (boring technology thesis Mckinley; monolith-first; serverless vs VPS tradeoffs for ≤$100/mo infra; framework selection for shipping speed — Rails/Django/Laravel/Next.js/Remix/SvelteKit; managed services over self-hosted whenever possible; database-as-a-service Supabase/PlanetScale/Neon/Turso; auth-as-a-service Clerk/Auth0/Supabase Auth; payment integration Stripe/Paddle/LemonSqueezy; deployment Vercel/Fly.io/Railway/Render; monorepo vs polyrepo for solo; AI-assisted coding Cursor/Copilot as force multiplier); (c) distribution and growth without a marketing team (SEO as moat for micro-SaaS Ahrefs-style content marketing on 1-person budget; Product Hunt launches; AppSumo lifetime deals tradeoffs; cold email outreach; Twitter/X building in public; IndieHackers community distribution; integration marketplaces Shopify/WordPress/Zapier/Slack app directories as channels; affiliate programs; content marketing at scale-of-one); (d) pricing and monetization (SaaS pricing psychology Patel/Campbell; freemium vs free trial vs paid-only; per-seat vs usage-based vs flat-rate; annual discount strategies; grandfathering existing customers; churn reduction for micro-SaaS — Baremetrics/ProfitWell/ChartMogul analytics; MRR/ARR/LTV/CAC at micro scale; the $10K MRR milestone psychology); (e) solo founder mental model and lifestyle design (default alive vs default dead Graham; ramen profitability Levels; lifestyle business vs growth business spectrum; burnout prevention for solo operators — no team to delegate to; time management and context-switching costs; geographic arbitrage and remote-first; the 'build once sell twice' asset mindset; community as support network IndieHackers/WIP/MicroConf); (f) legal and operational basics (incorporation LLC/Ltd/Gm

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Post-writing SEO validation with pass/fail checklist covering title tag length and keyword placement, meta description quality, heading hierarchy and keyword density, internal/external link audit with anchor text analysis, canonical URL verification, Open Graph meta tags (og:title, og:description, og:image), Twitter Card validation, URL structure optimization, and image alt text presence. Produces prioritized fix list with specific recommendations. Use when user says "seo check", "check seo", "validate seo", "blog seo", "seo validation", "on-page seo", "title tag check", "meta description check", "heading check", "link audit".

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Generate structured 8-section validation reports with verdict (GOOD/BAD/NEEDS MAJOR WORK), strengths, critical flaws, blindspots, and concrete path forward. Use after strategic-cto-mentor has completed validation analysis and needs to produce final deliverable.

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Design a cache invalidation and eviction strategy — event-driven invalidation and thundering herd prevention. Use when asked to "design cache invalidation", "fix stale cache data", or "prevent a thundering herd".

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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

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