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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Audit a GTK4/libadwaita app for GNOME HIG compliance across 12 categories (text, icons, layout, shortcuts, accessibility, color, dialogs, responsiveness, CSS, GSettings, i18n), then fix violations category by category. Use when asked to audit, review, polish, or "make HIG-compliant" a GNOME app, or before a release/Flathub submission.

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Evaluate an interface from a UX perspective, assessing hierarchy, information architecture, emotional resonance, cognitive load, and overall quality with evidence-linked judgments and actionable feedback. Use when the user wants an overall design or UX review—not when the main need is measurable accessibility/performance diagnosis, or final micro-detail polish.

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Build or improve UI test coverage for visual regression, interactions, and accessibility. Use when the user asks for a test strategy, automated tests, testing setup, or fixes to flaky UI tests. A one-time browser inspection or visual review does not require a new test suite.

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Run multiple Reforge-guided section-refactor lanes in parallel, each in its own worktree/branch off origin/main, with a score-blind adversarial review panel gating every commit, one draft PR per section. Use when the user wants to reduce Reforge surface/internal score across several sections at once via architecturally-correct deletions (dead surface, entity-leak removal, cross-section consumers moved onto the public contract) — not by relocation, parameter bags, or accessibility-dodging. Wraps the per-lane process in .codex/skills/humans-refactor. Triggers: 'refactor swarm', 'parallel section refactors', 'run reforge refactor on Users/Tickets/...', 'burn down surface score across sections'. Has an intensity dial (light|standard|deep) and a workflow|solo execution mode to trade token burn against autonomy per unit of output.

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Review UI code for Web Interface Guidelines compliance. Use when asked to "review my UI", "check accessibility", "audit design", "review UX", or "check my site against best practices".

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Builds production-quality, accessible, responsive user-facing UIs. Use when building or modifying interfaces and pages, creating components, implementing layouts, meeting WCAG accessibility requirements, managing state, or when the output needs to look and feel production-quality rather than AI-generated.

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Full QA review pipeline — security audit (OWASP Top 10), performance analysis, accessibility check (WCAG 2.1 AA), and code quality review

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Design workflow — create design systems, DESIGN.md, and design tokens with anti-pattern enforcement and accessibility checks

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Review changes for correctness, security, accessibility, and performance. Use for scoped quality reviews or verification plans; bug fixes use oma-debug.

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Implement accessibility. TRIGGERS - Use when user needs help with a11y-implementation-guide related tasks.

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Windows アプリ開発 (Fluent Design / WinUI 3) のデザインガイドライン。 layout, alignment, spacing, geometry, elevation, breakpoints, Color, materials, Mica, Acrylic, Smoke, Reveal Focus, Reveal Highlight (非推奨), typography, Segoe Fluent Icons, app icons, motion, easing, page transitions, connected animation, parallax, reduce motion, haptics, NavigationView, TitleBar, TabView, CommandBar, menus, keyboard accelerators, access keys, accessibility, high contrast, globalization, RTL, widgets design。

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Motion (旧 Framer Motion) アニメーションライブラリ リファレンス。motion/react, vanilla JS, Vue 版 motion-v (v-motion ディレクティブ)。 AnimatePresence, AnimateView, LayoutGroup, LazyMotion, MotionConfig, Reorder, useAnimate, useScroll, useSpring, useTransform, useMotionValue, useInView, motionValue。 animate, animateView, scroll, inView, hover, press, stagger, spring, timeline, transitions, styleEffect, threeEffect。Motion+ Carousel, Cursor, Ticker, Typewriter, AnimateNumber。 layout, drag, gestures, SVG, Tailwind, Lenis 連携。accessibility, performance, bundle 最適化, troubleshooting。

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Claude Code (code.claude.com) の各サーフェス（Desktop / IDE / Web / mobile / ターミナル UX）リファレンス。 Desktop app (launch.json, scheduled tasks, WSL, Linux, iOS simulator)、 VS Code / JetBrains / Chrome 拡張 (Claude in Chrome)、 claude.ai/code クラウドセッション (--cloud, --teleport, Projects)、mobile、 interactive mode, fullscreen, /tui, voice dictation, accessibility, computer use, artifacts。

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Operate desktop apps and isolated browsers on registered computers. Use for tasks that require an app interface, accessibility, screenshots or recording. Use Chromewhale for the user's signed-in Chrome.

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Design, implement, review, and audit Android Jetpack Compose UI/UX for phone interfaces. Use when a request concerns concrete Compose layout, components, interaction, accessibility, or visual behavior. Do not activate for framework or dependency presence alone; non-UI Android work is excluded.

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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

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Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.

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Validates animation durations, enforces typography scale, checks component accessibility, and prevents layout anti-patterns in Tailwind CSS projects. Use when building UI components, reviewing CSS utilities, styling React views, or enforcing design consistency.

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Find and fix WCAG 2.2 accessibility issues. Two modes — report (sweep a codebase or page, produce a prioritized written report, no edits) and fix (audit→edit→verify loop on a target). Prefers direct-CDP live-DOM auditing; falls back to a browser-MCP composition or HTML-string audits.

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Diff a live page's accessibility violations against a baseline — by default compares uncommitted changes (stash-based), or pass --branch [<name>] to diff against a branch. Reports only new violations introduced, violations fixed, and pre-existing count. Use `scan` for a full audit with no diffing.

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