Designs QC, corrects signal drift, removes batch effects, filters features, normalizes samples, and imputes missing values for untargeted LC-MS/GC-MS metabolomics, framing each step as a measurement model that can create or erase biological signal. Use when processing a peak/feature table before statistical analysis, choosing a drift-correction or sample-normalization method, deciding QC RSD vs D-ratio filtering, or handling left-censored missing values. The feature table is produced by metabolomics/xcms-preprocessing or metabolomics/msdial-preprocessing; transformation/scaling for modeling defers to metabolomics/statistical-analysis; cross-study design issues link to experimental-design/batch-design.
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huang-sh/DeepScience☆ 42026年7月15日 更新
Turns untargeted LC-MS/MS features (m/z, RT, MS/MS) into confidence-stratified metabolite annotations using spectral-library matching (matchms), in-silico tools (SIRIUS/CSI:FingerID, MetFrag) and molecular networking, and assigns a defensible MSI/Schymanski confidence level to each. Use when naming detected features, scoring MS/MS against a reference library, running SIRIUS, or deciding what confidence level an evidence set actually supports. For upstream feature extraction see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for downstream enrichment that must respect these levels see metabolomics/pathway-mapping; for lipid-specific structural annotation see metabolomics/lipidomics.
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huang-sh/DeepScience☆ 42026年7月15日 更新
Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.
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huang-sh/DeepScience☆ 42026年7月15日 更新
Automate headless CMS operations in Contentful -- list spaces, retrieve space metadata, and update space configurations through the Composio Contentful integration.
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q2805187159/Anvil☆ 32026年6月24日 更新
Write, debug, and optimize GROQ queries for Sanity CMS in this portfolio
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PP-Namias/Portfolio☆ 22026年10月20日 更新
Syncs blog posts between local MD files and Sanity CMS. Use when the user wants to push local posts to Sanity, pull from Sanity, or see what would change.
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PP-Namias/Portfolio☆ 22026年10月20日 更新
Hunting skill for ssrf vulnerabilities. Built from 15 public bug bounty reports including AWS metadata SSRF (HackerOne $25k Analytics PDF, Shopify Exchange $25k, Capital One 106M-record breach, Dropbox/HelloSign $4,913), GCP metadata SSRF (Snapchat $4k), Azure IMDS SSRF (Azure DevOps $15k chain, ChatGPT Custom Actions MSRC), DNS rebinding SSRF (Concrete CMS, GitLab UrlBlocker), gopher-protocol-to-Redis-RCE (Yahoo Mail $15k), link-preview SSRF (Reddit Matrix $6k), and headless-browser PDF-generator SSRF chains. Use when hunting SSRF on any target — OOB Collaborator confirmation mandatory for blind cases.
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ajtazer/heckit☆ 22026年10月7日 更新
Comprehensive Windows privilege escalation methodology for offensive security engagements. Covers the full attack surface from a standard user shell to NT AUTHORITYSYSTEM: token impersonation via SeImpersonate and SeAssignPrimaryToken privileges using JuicyPotato, PrintSpoofer, GodPotato, SweetPotato, and RoguePotato; service misconfigurations including unquoted service paths, weak service DACLs, writable service binaries, and insecure service creation permissions; AlwaysInstallElevated MSI exploitation; DLL hijacking through search order abuse, phantom DLL loading, and writable PATH directory injection; UAC bypass techniques via fodhelper.exe, eventvwr.exe, CMSTP, and environment variable manipulation; scheduled task abuse for writable task actions and new task creation; registry autorun exploitation for persistence and escalation; PrintNightmare (CVE-2021-34527) for remote and local privilege escalation; and credential harvesting from SAM database extraction, DPAPI blob decryption, LSA secret dumping,...
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ajtazer/heckit☆ 22026年10月7日 更新