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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Generate pileup data for variant calling using samtools mpileup and pysam. Use when preparing data for variant calling, analyzing per-position read data, or calculating allele frequencies.

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Meta-skill that orchestrates the discourse skill suite: routes between steel-man-argument, socratic-questioning, toulmin-argument-analysis, logical-fallacy-detector, bad-faith-rhetoric-detector, discourse-elision-analyzer, forensic-speech-structure, and productive-discourse-facilitator. Use when analyzing conversations, facilitating discourse, or operating as a dialogue copilot. Maintains mode (silent analysis, coaching overlay, active facilitator) and decides which skills to invoke based on conversation dynamics.

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Tracks cumulative LLM costs across DAG execution and makes real-time decisions to stay within budget. Downgrades models, skips optional nodes, or stops early when cost exceeds thresholds. Use when managing execution budgets, analyzing cost breakdowns, or optimizing model routing for cost. Activate on "cost budget", "too expensive", "reduce cost", "cost optimization", "model downgrade", "budget exceeded". NOT for LLM model selection logic (use llm-router), pricing comparisons across providers, or billing/invoicing.

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Build or improve a Coval dashboard with metric visualizations backed by real data. Creates new dashboards from scratch or rebuilds existing ones by analyzing usage patterns, metric frequency, and data density. Use when user says "create a dashboard", "build a dashboard", "improve my dashboard", "add widgets", "visualize my metrics", "make a performance dashboard", or "dashboard for my runs".

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Search Experience Optimization: reads Google SERPs backwards to detect page-type mismatches, derives user stories from search intent signals, and scores pages from multiple persona perspectives. Identifies why well-optimized pages fail to rank by analyzing what Google rewards for each keyword. Use when user says "SXO", "search experience", "page type mismatch", "SERP analysis", "user story", "persona scoring", "why isn't my page ranking", "intent mismatch", or "wireframe".

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Automatically creates user-facing changelogs from git commits by analyzing history, categorizing changes, and transforming technical entries into customer-friendly release notes. Use when preparing release notes from commit logs.

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When the user requests information about academic benchmarks, datasets, or research papers, particularly in machine learning, deep learning, or logical reasoning domains. This skill enables systematic research of academic benchmarks by searching web sources, downloading and analyzing arXiv papers, extracting key metadata (number of tasks, training availability, difficulty levels), and compiling comparative summaries. It triggers on requests involving dataset comparisons, benchmark analysis, or academic paper research for table creation.

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Analyze context and decide on continuation via Stop hook. Use when determining if work should continue, analyzing completion status, making continuation decisions, or implementing the Two-Claude pattern.

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Complete workflow for static structural analysis. Use when analyzing stress, displacement, or reaction forces under constant loads. For strength and stiffness evaluation.

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Expert in statistical analysis for blind A/B and ABX audio testing. Validates randomization, calculates statistical significance, and ensures proper experimental design. Use when implementing A/B test features or analyzing test results.

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[30] ANALYZE. Understand how changes impact the system — what's the core, what's affected, what depends on what. Use when planning changes, analyzing systems, debugging issues, or anytime you need to see the full picture of cause and effect. Triggers on "what's affected", "impact analysis", "dependencies", "scope mapping", or when you need to understand ripple effects.

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[31] ANALYZE. Universal deep thinking methodology for any situation requiring quality reasoning. Use when solving problems, debugging, making decisions, analyzing code, planning, reviewing, or anytime you need thorough thinking instead of surface-level responses. Triggers on "think deeply", "analyze thoroughly", "reason carefully", "deep thinking", "understand completely", or any task requiring careful thought.

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Performance optimization guidelines for OneKey React/React Native applications. Use when optimizing app performance, fixing UI freezes/lag, reducing re-renders, handling concurrent operations, or analyzing performance bottlenecks. Triggers on performance, optimization, optimize, slow, lag, freeze, hang, jank, stutter, memory, leak, concurrent, batching, batch, memoization, memo, bridge, windowSize, contentVisibility, FlashList, re-render, fps, tti, bundle.

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Sentry error tracking and monitoring for OneKey. Use when configuring Sentry, filtering errors, analyzing crash reports, or debugging production issues. Covers platform-specific setup (desktop/mobile/web/extension) and error filtering strategies.

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Comprehensive patterns and techniques for analyzing compiled binaries, understanding assembly code, and reconstructing program logic.

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Architectural decision-making framework. Requirements analysis, trade-off evaluation, ADR documentation. Use when making architecture decisions or analyzing system design.

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Debug LangChain and LangGraph agents by fetching execution traces from LangSmith Studio. Use when debugging agent behavior, investigating errors, analyzing tool calls, checking memory operations, or examining agent performance. Automatically fetches recent traces and analyzes execution patterns. Requires langsmith-fetch CLI installed.

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Identifies high-quality leads for your product or service by analyzing your business, searching for target companies, and providing actionable contact strategies. Perfect for sales, business development, and marketing professionals.

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Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization. When Claude needs to work with spreadsheets (.xlsx, .xlsm, .csv, .tsv, etc) for: (1) Creating new spreadsheets with formulas and formatting, (2) Reading or analyzing data, (3) Modify existing spreadsheets while preserving formulas, (4) Data analysis and visualization in spreadsheets, or (5) Recalculating formulas

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This skill calculates key financial ratios and metrics from financial statement data for investment analysis

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