“block”的搜索结果

Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

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Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, building-block availability (eMolecules, Enamine, Mcule), forward prediction validation (Molecular Transformer), and disconnection-aware multi-objective search (MO-MCTS). Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

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Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit reaction mining), product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enumerating analog series, deriving structure-activity rules, or extracting transformations from reaction data.

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The CI cost rules ($100/week of real money, all CI). Use when editing .github/workflows, adding a schedule or cron, dispatching a workflow, publishing a package version, hitting a billing block, or seeing a CI SPEND OFF TRACK line, ci-breaker issue or spend alert.

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Run a structured code review — produces a Review Report with CRITICAL, WARNING, and SUGGESTION findings; CRITICAL findings block merge.

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Analyze text and images for harmful content with customizable blocklists.

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Comprehensive guidance for implementing asynchronous Python applications using asyncio, concurrent programming patterns, and async/await for building high-performance, non-blocking systems.

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Wait N seconds (default 20) via a blocking Node.js timer, for testing

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Rename a thesis file when company name changes. Atomically updates filename, all inbound wikilinks across the vault, graph adjacency entry header, sector note Active Theses entry, snapshot snapshot_of references, and _hot.md mentions. Use when company changes name (FB → META, Square → Block, etc.), or when correcting a typo in a thesis filename.

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Read-only sanity-check of EcoSIM plant_trait.*.desc parameter values for the first grid. Use when validating plant trait description files, enforcing clean C3/C4 physiological parameterization, reviewing photosynthetic kinetics, active leaf/root protein allocation, and root hydraulics such as RSRR, RVSR, and ARSRA, or checking ranges, units, and woody/herbaceous block consistency before running EcoSIM. Never edit or replace the `.desc` file.

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Integrate Firebase Auth (authentication + domain restriction) into internal applications. Includes domain restriction via Blocking Functions and user registration to Firestore.

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Investigate implementation failures using root-cause-first debugging. Use when an implementer is blocked, verification fails, or repeated remediation does not converge.

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Notion API for creating and managing pages, databases, and blocks via curl. Search, create, update, and query Notion workspaces directly from the terminal.

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SiYuan Note API for searching, reading, creating, and managing blocks and documents in a self-hosted knowledge base via curl.

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Query Base (Ethereum L2) blockchain data with USD pricing — wallet balances, token info, transaction details, gas analysis, contract inspection, whale detection, and live network stats. Uses Base RPC + CoinGecko. No API key required.

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Query Solana blockchain data with USD pricing — wallet balances, token portfolios with values, transaction details, NFTs, whale detection, and live network stats. Uses Solana RPC + CoinGecko. No API key required.

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Classic block-game inspired design with playful colors, bold display fonts, and compact, high-energy layouts.

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A playful, arcade-inspired interface for games — built on the VT323 pixel typeface, hard-edged 0px corners, chunky pill buttons that physically press into solid offset blocks

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A playful, energetic, cartoonesque interface inspired by friendly children's-book illustrations — warm cream backgrounds, big bold custom display typography, saturated brand color blocks, thick black outlines, generously rounded shapes

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Notebook-collage weekly digest template — spiral-bound reporter's notebook aesthetic with cobalt tape, mint folder tab, binder clip, receipt block, ruled baseline grid; built for AI-product / team / design weekly digests delivered as a downloadable high-res page.

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Modular grid layout with card-like blocks, clear hierarchy, soft spacing, and subtle visual contrast for organized, scannable interfaces.

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Use when an approved PRD roadmap must go to GitHub — 'publicar o roadmap no GitHub', 'criar o project e as issues do PRD', 'publish PRD roadmap' — handing over to pwdev-github (Project from a template, issues, sub-issues, blocked-by). Do NOT use for a single issue with the whole PRD (prd-export).

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Use when the user wants a code review of an explicit range or set of files — correctness, security, performance, conventions, tests — with stable findings (CR-nnn, BLOCKER..INFO) and rule citations — 'revisar os últimos commits', 'code review da feature X', 'review base..HEAD'. Plans a REPORT-mode review (no code changes, no commit). Do NOT use to fix code (feat-feature / feat-quick), to write tests (feat-test) or for UI/UX design critique.

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Use quando um roadmap pwdev-roadmap/1 (roadmap.json) precisar ir para o GitHub — 'publicar o roadmap', 'criar as issues do roadmap', 'publish roadmap.json' — com issues, sub-issues, milestones, blocked-by e campos do Project, com dry-run, idempotente e retomável. Não use para uma issue avulsa (github-issues).

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