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Reduce defensive writing in drafts and revisions by removing unnecessary caveats, disclaimers, hedges, apology-like framing, negative self-limiting statements, and over-explanations while preserving necessary scope, accuracy, safety, legal, ethical, and methodological limits. Use when drafting or revising academic writing, papers, essays, abstracts, introductions, contribution statements, discussions, conclusions, technical explanations, grant writing, product writing, policy writing, professional reports, or any text the user wants to be clearer, stronger, more direct, more concise, more confident, less verbose, less caveated, less apologetic, or less defensive.

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Predict peptide-MHC class II (HLA-DR/DQ/DP) binding and presentation for CD4 T-cell epitopes with NetMHCIIpan-4.3 and MixMHC2pred-2.0. Covers why class II is far less reliable than class I (open binding groove, 9-mer register ambiguity, sparse noisy training data, DR>DP>DQ accuracy asymmetry), the DQ/DP heterodimer alpha/beta pairing trap, and the looser 1%/5% %Rank thresholds. Use when predicting CD4 epitopes for vaccine help, mapping class II neoantigens, or scoring long peptides against DR/DQ/DP. For CD8/class I see mhc-binding-prediction.

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Basecalls raw Oxford Nanopore signal (POD5/FAST5) into reads with Dorado, choosing the chemistry-matched model and accuracy tier (fast/hac/sup), requesting modified bases (5mCG_5hmCG, 6mA, m6A) at basecall time, and handling duplex, demultiplexing, trimming, and HERRO read correction. Covers why the model+version is an irreversible analysis decision, why methylation cannot be recovered later, and why downstream polish/variant models must match the basecaller. Use when converting POD5/FAST5 to reads, picking a Dorado model for R9/R10 or RNA004, enabling methylation calling, basecalling duplex, demultiplexing barcoded runs, or correcting reads for assembly.

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Interactive cell annotation and image QC for IMC/MIBI using napari, napari-imc, Mantis Viewer, and cytomapper, covering the pixels-to-cell-table bridge, overlaying masks to catch segmentation/spillover artifacts, inter-annotator variability as the accuracy ceiling, contrast-as-threshold, and building class-balanced ground-truth label sets. Use when manually labeling cells, generating training data for a classifier, QC-ing segmentation on the image, confirming clusters are spatially real, or choosing an annotation viewer.

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Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish, Polypolish and pypolca (Illumina, repeat-aware), Pilon (legacy short-read), NextPolish/NextPolish2, Hapo-G (haplotype-aware), ntEdit, and DeepPolisher/PEPPER-Margin-DeepVariant for human. Covers the do-not-polish-HiFi rule, the medaka basecaller-model footgun, held-out Merqury QV as the only honest stop signal, and the haplotype-collapse trap. Use when correcting homopolymer indels or residual SNPs in a long-read assembly, deciding if a HiFi assembly needs polishing, or choosing an ONT vs hybrid vs short-read polishing chain.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, edit, or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

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Computes multi-constellation Global Positioning System (GPS) or Global Navigation Satellite System (GNSS) positions from RINEX v3 data using rinexread, gnssmeasurements, receiverposition, and gnssoptions. Filters by constellation, elevation mask, C/N0, and observation code. Reports DOP, scatter RMS, and satellite count. Use when processing GNSS data, computing positions from RINEX files, analyzing accuracy, comparing constellations, or evaluating satellite geometry. Do NOT use for carrier-phase RTK/PPP, IMU fusion, orbit propagation, NMEA streaming, or RINEX v4.

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Use this skill to classify tabular data end-to-end in MATLAB — load a dataset, prepare and clean it, select promising classifiers, train them, and compare accuracies with cross-validation, holdout, or hyperparameter optimization plus statistical tests. TRIGGER when: user asks to classify tabular data, pick classifiers for a dataset, compare classifier accuracy, run cross-validation or a holdout evaluation, or find the best model with statistical uncertainty. DO NOT TRIGGER when: user has non-tabular inputs (images, sequences, time series), wants a regression model, is training a specific neural network architecture (use matlab-train-network), or wants cost-sensitive learning or an arbitrary class-prior vector (this skill only supports the built-in uniform-prior toggle for imbalanced data).

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Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, edit, or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

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Pre-publish QA framework for content. Brief adherence, voice consistency, fact accuracy, structure and clarity, AI-content audit, SEO and AEO compliance, internal linking and schema validation, QA at scale via sampling, the QA workflow, and the discipline that distinguishes catch-problems QA from checkbox QA. Triggers on editorial QA, content review, pre-publish review, content audit, content QA process, AI-content audit, hallucination check, content sampling, programmatic QA, voice consistency check, brief adherence check. Also triggers when a content team is shipping sloppy work, when AI-co-authored content is reaching publish unaudited, when a QA process burns reviewers out, or when a programmatic SEO set needs sampling discipline. On a voice consistency check, this skill owns checking a draft against an existing voice system at the publish gate; use `brand-voice` when the voice system itself needs defining or documenting.

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Detect documentation drift against code changes, score staleness, validate API docs via AST parsing, and audit link integrity. Use when docs fall out of sync with code, preparing releases, running CI doc gates, or auditing doc accuracy.

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Analyzes pipeline coverage, tracks forecast accuracy with MAPE, and calculates GTM efficiency metrics for SaaS revenue optimization

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Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, update or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

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Ultra-compressed communication mode (lite / full / ultra) that cuts token usage ~75% by speaking like caveman while keeping full technical accuracy. Use when the user requests "caveman mode", "less tokens", "be brief", or when output budget is tight.

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Prevent 此地无银三百两式 residue: finalize artifacts without echoing rejected session-only alternatives into labels, metadata, commits, PRs, or handoffs. Use after corrections or discarded proposals. Not for ordinary deletion, deprecation, migration, or exclusions materially required for safety, accuracy, compatibility, audit, quotation, or requested comparison.

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Review the agent's own recent outputs for quality and accuracy

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Review the week using accumulated session evidence — retrieval rates, hint depths, calibration accuracy, transfer and unassisted results. The learner identifies patterns and sets a strategy goal. Use weekly or after a multi-session period.

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Pick the right LLM for CONTRACT REVIEW — reviewing an existing agreement for risk, deviations from standard, missing protections, and internal contradictions, and proposing redlines. Vendor-neutral routing grounded in mid-2026 legal benchmarks. Contract review is a COMPOSITE skill (extraction + reasoning + redlining + conflict-detection), so this routes by the dominant sub-task. Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/ language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model to review this contract / NDA / MSA", "best AI to redline", "route this contract review", or is about to review an agreement without a fixed model.

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Pick the right LLM for CONTRACT DRAFTING — generating, redlining, or rewriting contract language from instructions. Vendor-neutral routing grounded in mid-2026 legal benchmarks (legalbenchmarks.ai Contract Drafting). Asks up to 4 quick questions (cost, speed, accuracy/ stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model should I use to draft this clause/agreement", "best AI for drafting contracts", "route this drafting task", or is about to generate/redline contract text and hasn't fixed a model.

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Pick the right LLM for LEGAL RESEARCH & ANALYSIS — issue-spotting, rule application, case/statute analysis, memos, and multi-step agentic research. Vendor-neutral routing grounded in mid-2026 benchmarks (Vals AI LegalBench across 124 models; Harvey Legal Agent Benchmark for agentic work). Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model for legal research / case analysis / a memo", "best AI for legal reasoning", "route this research task", or is starting legal analysis without a fixed model.

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Pick the right LLM for LEGAL INFO EXTRACTION — pulling facts, clauses, dates, parties, obligations, and structured fields out of contracts and legal documents. Vendor-neutral routing grounded in mid-2026 benchmarks (legalbenchmarks.ai Info Extraction; CUAD/MAUD/ACORD). Asks up to 4 quick questions (cost, speed, accuracy/stakes, privacy/jurisdiction/language), then recommends a primary model + fallback + what to avoid + what a human must verify. Use when someone asks "which model should I use to extract clauses/data from these documents", "best AI for contract data extraction", "route this extraction task", or is about to pull structured fields from legal docs without a fixed model.

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Adversarial verification of AI-generated legal content with systematic fact-checking, source validation, and quality control. Use when a user asks to verify, fact-check, red-team, validate sources, or quality-control a legal document, briefing, compliance summary, or regulatory analysis before it is distributed to clients, stakeholders, or published. Trigger phrases include "verify", "fact-check", "red team", "red-flag", "check accuracy", "validate sources", "quality control", "is this correct", and "review for errors". Produces a structured verification report with severity-categorized errors, verified sources, unsupported claim list, missing disclaimers, and an explicit distribution-readiness assessment.

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Mandatory external verification workflow for ALL non-trivial factual claims before presenting them as true. This skill MUST be used whenever Claude is asked to research any topic, answer factual questions, provide current information, draft documents containing factual claims, give legal advice or cite legal authority, discuss current events or public figures, provide technical or scientific information, state statistics or data points, or answer ANY question where the answer could have changed over time. Also trigger when the user asks Claude to 'check', 'verify', 'confirm', 'research', 'look up', or 'find out' anything, or when the user needs information that requires freshness, precision, or source accuracy. This skill overrides any default tendency to answer from memory. If a task involves stating facts, citing sources, or providing current information — use this skill.

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