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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Analisa custo AWS e identifica desperdício em EC2, RDS, S3, EKS, EBS, Elastic IP, NAT Gateway e tráfego. Use quando o usuário disser "custo", "fatura", "está caro", "FinOps", "reduzir gasto AWS", "Cost Explorer", "otimizar custo". Quase todo leitura — seguro por natureza.

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Arquitetura e diagnóstico AWS — VPC, EC2, ECS, EKS, ALB, NLB, RDS, ElastiCache, S3, CloudFront, Route53, IAM, WAF, GuardDuty. Use quando o usuário disser "AWS", "VPC", "ALB", "RDS", "revisar a arquitetura", "Well-Architected", "subnet", "security group", "IAM", ou citar qualquer serviço AWS. Leitura livre; qualquer mudança passa pelo portão de confirmação.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Expert knowledge of EESSI integration via EUX/RINA in melosys-api. Use when: (1) Understanding BUC lifecycle and SED exchange (A-series A001-A012, X-series X001-X013, plus H_BUC/UB_BUC), (2) Debugging SED sending/receiving via EessiClient (opprettBucOgSed, sendSedPåEksisterendeBuc, X008 invalidation, X009 purring), (3) Understanding LA_BUC types and their purposes, (4) Investigating EUX API errors, RINA case (rina saksnummer / saksrelasjon) lookup, (5) Understanding mottakerinstitusjoner / institution catalog lookup.

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Expert Kubernetes architect specializing in cloud-native infrastructure, advanced GitOps workflows (ArgoCD/Flux), and enterprise container orchestration. Masters EKS/AKS/GKE, service mesh (Istio/Linkerd), progressive delivery, multi-tenancy, and platform engineering. Handles security, observability, cost optimization, and developer experience. Use PROACTIVELY for K8s architecture, GitOps implementation, or cloud-native platform design.

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This skill teaches security teams how to detect and respond to unauthorized cryptocurrency mining operations in cloud environments. It covers identifying cryptomining indicators through compute usage anomalies, network traffic patterns to mining pools, GuardDuty CryptoCurrency findings, and runtime process monitoring on EC2, ECS, EKS, and Azure Automation workloads.

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This skill teaches security teams how to deploy and operationalize Amazon GuardDuty for continuous threat detection across AWS accounts and workloads. It covers enabling protection plans for S3, EKS, EC2 runtime monitoring, and Lambda, interpreting finding severity levels, and building automated response workflows using EventBridge and Lambda.

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Auditing Kubernetes cluster RBAC configurations to identify overly permissive roles, wildcard permissions, dangerous ClusterRoleBindings, service account abuse, and privilege escalation paths using kubectl, rbac-tool, KubiScan, and Kubeaudit.

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Kubernetes cluster attack techniques covering the full attack lifecycle from initial foothold in a pod to cluster-wide compromise. Covers service account token theft and impersonation, RBAC misconfiguration exploitation including wildcard permissions and privilege escalation via role binding, direct etcd access for secret extraction, kubelet API abuse on port 10250 and read-only port 10255, pod escape via hostPID hostNetwork and hostPath volume mounts, Kubernetes secrets enumeration and decoding, admission controller bypass techniques, network policy bypass and lateral movement, cloud metadata service access from pods for credential theft on AWS EKS GCP GKE and Azure AKS, CRD and operator abuse for persistence, and node compromise via DaemonSet deployment. Tools include kubectl, kube-hunter, peirates, kubeaudit, kdigger, kubeletctl. Maps to MITRE ATT&CK T1609 Container Administration Command, T1610 Deploy Container, T1613 Container and Resource Discovery. Use this skill when assessing Kubernetes clusters,...

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Cloud security attack methodology covering AWS, Azure, and GCP. Includes credential harvesting (IMDS, ~/.aws, env vars, leaked CI secrets, instance roles), enumeration with cloud-specific tools (pacu, ScoutSuite, Prowler, ROADtools, gcp_enum), privilege escalation paths (IAM PassRole, AssumeRole chains, Lambda/Functions privilege flips, Azure Owner-on-self, GCP serviceAccountTokenCreator), persistence techniques (IAM user/key creation, AAD app registration, GCP svc account key creation, EventBridge/Logic Apps backdoors), data exfiltration (S3/Blob/GCS, snapshot share, RDS/CosmosDB/Cloud SQL exfil), cloud-native lateral movement (cross-account assume, Azure AD multi-tenant, GCP project hierarchy), serverless attacks (Lambda env vars, layer hijack, Step Functions), Kubernetes-on-cloud (EKS/AKS/GKE-specific paths to node and AWS metadata), and CSPM evasion (CloudTrail blind spots, GuardDuty mute, Sentinel rule shaping). Use when the engagement scope is cloud accounts, when you've stolen cloud credentials, or...

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