“decomposition”的搜索结果

Application architecture patterns and code organization — clean architecture, hexagonal architecture, feature-based structure, dependency inversion, module boundaries, SOLID principles at module scale. Activate on "clean architecture", "hexagonal architecture", "feature-based structure", "dependency inversion", "module boundaries", "architecture pattern", "folder structure", "fat controller", "circular dependency", "IoC container". NOT for microservice decomposition (use microservices-patterns) or database schema design (use database-design-patterns).

中文简介正在准备中。当前显示原文说明。

Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

中文简介正在准备中。当前显示原文说明。

Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

中文简介正在准备中。当前显示原文说明。

Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.

中文简介正在准备中。当前显示原文说明。

Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.

中文简介正在准备中。当前显示原文说明。

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

中文简介正在准备中。当前显示原文说明。

Manages git worktrees for parallel agent isolation. Creates isolated worktrees for parallel agents on parallel/{name}-{timestamp} branches, merges results with conflict detection, prunes stale metadata, and reports health status. NOT for user-initiated feature branches — use git worktree directly for that.

中文简介正在准备中。当前显示原文说明。

Use when stuck on approach (not debugging). Strategic unsticking via 7 non-default techniques: simplification cascades, collision-zone thinking, meta-pattern recognition, inversion, scale game, first principles, via negativa. Triggers on complexity spiraling, innovation block, recurring patterns across domains, forced-assumption solutions, scale uncertainty, told-it's-impossible, or bloated systems needing subtraction. For evidence-based root-cause debugging, use mk:sequential-thinking instead.

中文简介正在准备中。当前显示原文说明。

Use when refining a draft user prompt before sending it to a coding agent. Decomposes goal/context/constraints/acceptance/output-format, detects ambiguity and model-coupled framing, then emits a model-agnostic rewrite. Supports --analyze, --score, and --deep. NOT for prompts from scratch (mk:brainstorming), plans/reviews (mk:elicit), implementation plans (mk:plan-creator), or general codebase scouting (mk:scout).

中文简介正在准备中。当前显示原文说明。

Auto-decompose large tasks into DAG-compatible parallel subtasks

中文简介正在准备中。当前显示原文说明。

Decomposition playbook + specialist-roster conventions + anti-temptation rules for an orchestrator profile routing work through Kanban. The "don't do the work yourself" rule and the basic lifecycle are auto-injected into every kanban worker's system prompt; this skill is the deeper playbook when you're specifically playing the orchestrator role.

中文简介正在准备中。当前显示原文说明。

Expert-level linear algebra knowledge. Use when working with vectors, matrices, determinants, eigenvalues, linear transformations, vector spaces, inner products, decompositions, or applications in machine learning and physics. Also use when the user mentions 'matrix', 'determinant', 'eigenvalue', 'eigenvector', 'linear transformation', 'vector space', 'basis', 'orthogonality', 'SVD', 'PCA', 'least squares', 'null space', or 'rank'.

中文简介正在准备中。当前显示原文说明。

Structured step-by-step problem decomposition and iterative analysis; explicit request only, never for regular coding tasks, and at most once per task.

中文简介正在准备中。当前显示原文说明。

Use when staging multi-component or uncertain work — tackle the load-bearing unknown first (risk-first decomposition), not the easy parts first.

中文简介正在准备中。当前显示原文说明。

Draft or refine IDD-ready GitHub issues, roadmap issues, and sub-issues before the normal IDD execution loop begins. Use when a request is too large or ambiguous for one reviewable change, when work needs decomposition or dependency encoding, or when the user asks for issue drafting, roadmap planning, or parallelizable task breakdown.

中文简介正在准备中。当前显示原文说明。

Lightweight multi-agent research orchestration using one coordinator, three domain leads, and three lightweight research agents. Use for medium-size research, market scans, competitor comparisons, prior-art style exploration, report planning, and any task that benefits from parallel domain decomposition without running a full high-cost research lab.

中文简介正在准备中。当前显示原文说明。

Load for behavior-preserving rename, move, decomposition, dead-code removal, dependency cleanup, record/class conversion, or immutable contract migration that needs caller, flow, test, and impact analysis; not for feature work or one-line cleanup.

中文简介正在准备中。当前显示原文说明。

LoRA · Hugging Face — We propose Low-Rank Adaptation, or LoRA, which freezes the pre-trained model weights and injects trainable rank decomposition …;

中文简介正在准备中。当前显示原文说明。

Econometrics skill for time series analysis. Activates when the user asks about: "time series", "stationarity", "unit root test", "ADF test", "KPSS test", "ARIMA", "ARMA", "autocorrelation", "ACF", "PACF", "VAR model", "VECM", "Granger causality", "cointegration", "impulse response function", "forecast", "seasonal decomposition", "ARCH", "GARCH", "时间序列", "平稳性检验", "单位根", "自回归", "格兰杰因果", "协整", "脉冲响应", "预测", "向量自回归"

中文简介正在准备中。当前显示原文说明。

Knowledge base from the GAO Agile Assessment Guide (GAO-24-105506, 2023). Use for assessing and managing Agile software development in federal programs: the Agile Manifesto and framework family (Scrum, Kanban, XP, SAFe, DA, DSDM, Lean, DevOps); the three adoption perspectives (team dynamics, program operations, organization environment); requirements decomposition (epics, features, user stories, INVEST, MoSCoW, definition of done); Agile-aware federal contracting (FAR, modular contracting, SOO/PWS/SOW, product owner vs. COR); program monitoring and control (WBS, cost, schedule, EVM at the feature level); Agile metrics (velocity, lead/cycle time, CFD, burn charts); and the auditor's key-question bank. Oversight- and acquisition-oriented: it tells you how to *assess and govern* Agile programs, not how to code. Thin on hands-on engineering practice, deep cost/schedule checklists (see gao-cost, gao-schedule), and any non-US-federal context.

中文简介正在准备中。当前显示原文说明。

Remove signs of AI-generated code from a codebase while preserving behavior. Use when editing or reviewing code to make it read like a human engineer on this team wrote it. Works through a test-guarded detect-modify-verify loop: pin down the functional contract and edge cases first, write or run tests as a safety net, then rewrite AI tells (redundant comments, emoji, verbose names, reflexive try/except, defensive null-guards, over-decomposition, speculative abstraction, dead code, non-idiomatic constructs, hallucinated dependencies) and re-verify after every change. The tests decide whether a defensive block is slop or a real safeguard.

中文简介正在准备中。当前显示原文说明。

Use when the user asks to "figure out where our direct traffic really comes from", "measure dark social", "add a how-did-you-hear-about-us field", or "show social drives signups without click data"; produces a share-link/UTM hygiene spec for owned share surfaces, a self-reported attribution field design that replaces an existing form field (free-text first, coded later), a GA4 direct-traffic decomposition read (deep-URL directs, mobile-app skew, private-push correlation) with every derived number hard-labeled Estimated/proxy, and a branded-search-lift proxy from GSC plus Wikipedia pageviews — the declared dark-social method behind ECHO O2. Not for paid-channel attribution reconciliation (platform-claimed vs analytics conversions) — use attribution-reconciler. 暗社交归因/直接流量分解/自报来源字段/分享链路UTM

中文简介正在准备中。当前显示原文说明。

Use when platform-reported conversions disagree with GA4/ecommerce, when you suspect Meta and Google are double-counting the same sales, or for a standing (monthly) reconciliation workbook that de-dups stacked credit against an order-ID truth set, normalizes attribution windows and currency, compares attribution models, and reads incrementality from a geo/holdout test. Not for the point-in-time R2 veto or RQS gate — use ad-account-auditor; not for the ROI/ROAS ratio math itself — use roi-calculator; not for organic dark-social share attribution or GA4 direct-traffic decomposition — use dark-social-attributor. 付费广告归因对账/去重/增量

中文简介正在准备中。当前显示原文说明。

Operate as an agentic engineer using eval-first execution, decomposition, and cost-aware model routing.

中文简介正在准备中。当前显示原文说明。