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Agente que simula Andrej Karpathy — ex-Director of AI da Tesla, co-fundador da OpenAI, fundador da Eureka Labs, e o maior educador de deep learning do mundo.

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Detect anomalies in DNP3 (Distributed Network Protocol 3) communications used in SCADA systems by monitoring for unauthorized control commands, firmware update attempts, protocol violations, and deviations from baseline traffic patterns using deep packet inspection and machine learning approaches.

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Sep 24, 2025 Deep Dive into Context Engineering for Agents Sep 18, 2025 Architectures for Multi-Agen

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Use when the user asks to "run a launch retro / post-mortem", "compare launch results vs targets by channel", or "decide what to keep or kill for the next launch"; produces a structured D1/W1/M1 retrospective — a per-channel actual-vs-target table (UTM-attributed own analytics as the truth column, platform self-reported numbers as reference, every figure labeled Measured / User-provided / Estimated), a 5-Whys chain on the single largest miss, keep / kill / change decisions per channel, 3-5 actionable learnings for the next launch, and an outcome snapshot submitted to the launch registry. Not for return math (CPA / ROI) — use roi-calculator; not for the stakeholder-facing report writeup — use report-generator; not for a metric deep-dive — use performance-analyzer. 发布复盘/渠道归因/5-Whys/keep-kill

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PyTorch deep learning development with transformers, diffusion models, and GPU optimization.

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Pick the right serving container for a SageMaker model deployment and find its current image URI. Use this skill whenever about to deploy a model to a SageMaker endpoint and an image URI needs to be chosen — including when the user says "deploy this LLM", "host this HuggingFace model", "serve this fine-tuned model", "deploy this embedding model", "host a reranker", "serve a sentence-transformers model", or when about to hardcode any container URI in deployment code. HuggingFace-curated Deep Learning Containers are ALWAYS preferred: HuggingFace vLLM (LLMs and generative rerankers), HuggingFace vLLM-Omni (multimodal), TEI (embeddings/cross-encoder rerankers), HF Inference Toolkit (other transformers). Generic images (AWS vLLM, DJL-LMI, SGLang) are used only when no HuggingFace image is compatible — never merely because they carry a newer version. Never hardcode a container URI from memory and never default to TGI. Prevents stale-image failures and wrong-region URIs.

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Detect anomalies in DNP3 (Distributed Network Protocol 3) communications used in SCADA systems by monitoring for unauthorized control commands, firmware update attempts, protocol violations, and deviations from baseline traffic patterns using deep packet inspection and machine learning approaches.

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Production-ready reinforcement learning algorithms (PPO, SAC, DQN, TD3, DDPG, A2C) with scikit-learn-like API. Use for standard RL experiments, quick prototyping, and well-documented algorithm implementations. Best for single-agent RL with Gymnasium environments. For high-performance parallel training, multi-agent systems, or custom vectorized environments, use pufferlib instead.

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High-performance reinforcement learning framework optimized for speed and scale. Use when you need fast parallel training, vectorized environments, multi-agent systems, or integration with game environments (Atari, Procgen, NetHack). Achieves 2-10x speedups over standard implementations. For quick prototyping or standard algorithm implementations with extensive documentation, use stable-baselines3 instead.

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Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training

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Maps query single-cell data onto reference atlases and transfers cell-type labels using scArches surgery (scVI/scANVI), Symphony, Azimuth, CellTypist, scPoli, popV, and foundation models, with explicit out-of-distribution and label-transfer uncertainty. Use when annotating new single-cell datasets against a pre-trained reference, deciding which mapping method fits, or judging whether transferred labels are trustworthy. For de novo clustering and manual annotation see single-cell/cell-annotation; for batch integration without a reference see single-cell/batch-integration.

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Use this skill for processing and analyzing large tabular datasets (billions of rows) that exceed available RAM. Vaex excels at out-of-core DataFrame operations, lazy evaluation, fast aggregations, efficient visualization of big data, and machine learning on large datasets. Apply when users need to work with large CSV/HDF5/Arrow/Parquet files, perform fast statistics on massive datasets, create visualizations of big data, or build ML pipelines that do not fit in memory.

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UMAP dimensionality reduction. Fast nonlinear manifold learning for 2D/3D visualization, clustering preprocessing (HDBSCAN), supervised/parametric UMAP, for high-dimensional data.

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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Prepare for tomorrow's meetings and tasks. Pulls calendar from Outlook via WorkIQ, cross-references open tasks and workspace context, classifies meetings, detects conflicts and day-fit issues, finds learning and deep-work slots, and generates a structured HTML prep file with productivity recommendations.

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You are an **expert onboarding specialist and knowledge transfer architect** with deep experience in remote-first organizations, technical team integration, and accelerated learning methodologies. Your role is to ensure smooth, comprehensive onboarding that transforms new team members into productive contributors while preserving institutional knowledge.

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Use when user requests research requiring multiple sources, comprehensive analysis, or synthesis across topics - technical research, domain knowledge gathering, market analysis, or learning about complex subjects

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Detect anomalies in DNP3 (Distributed Network Protocol 3) communications used in SCADA systems by monitoring for unauthorized control commands, firmware update attempts, protocol violations, and deviations from baseline traffic patterns using deep packet inspection and machine learning approaches.

中文简介正在准备中。当前显示原文说明。