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Help users debug PostHog Error Tracking stack-trace symbolication for any supported platform — JavaScript/TypeScript web, React Native (Hermes), Android (Proguard / R8), or iOS / macOS (dSYM). The PostHog symbol-set lookup flow is universal across platforms; build-tool and artifact details live in per-platform references (JavaScript is fleshed out, others come as we encounter them). Use when stack frames stay minified or obfuscated after symbols are uploaded, PostHog symbol sets show last_used but frames are not readable, chunk IDs or dSYM UUIDs do not match, "Token not found" appears, uploaded source maps / dSYMs / Proguard mappings look empty, or bundler / symbol-upload configuration needs troubleshooting.

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Authors reproducible Nextflow DSL2 pipelines built on reactive dataflow, where processes communicate only through channels and execution order is not guaranteed. Use when deciding channel/dataflow (Nextflow) vs rule-based (Snakemake) authoring; wiring queue vs value channels and fixing shared-reference exhaustion with .first(); composing DSL2 modules and subworkflows with take/main/emit; selecting container/conda profiles and pinning images by digest for portability across local/SLURM/LSF/AWS Batch/Google Batch/Kubernetes executors; diagnosing why -resume misses the cache (nondeterministic input order, mtime on network filesystems, mutable :latest tags) with cache 'lenient' and -dump-hashes; managing work/ vs publishDir and dynamic retry escalation; and choosing whether to adopt an nf-core community pipeline or author from scratch.

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ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.

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Metabolomics pathway analysis — metabolite identification (HMDB, KEGG, ChEBI), pathway mapping (Reactome, KEGG, MetaCyc), disease associations, enzyme/gene linkage. Use for metabolite-to-pathway-to-disease connections, BridgeDb-based ID conversion, and integrating metabolomics with gene-level pathway analyses.

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Lipid analysis and lipid-disease associations using LIPID MAPS classification, HMDB metabolite data, KEGG/Reactome lipid pathways (sphingolipid, eicosanoid, steroid, fatty acid), and PubChem chemical info. Use for lipid identification, lipid metabolism pathway mapping, and lipid-associated disease analysis (cardiovascular, diabetes, NAFLD).

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Enzyme kinetics — Michaelis-Menten Km, Vmax, kcat (turnover), and kcat/Km (catalytic efficiency / specificity constant) from substrate-velocity data, plus inhibition-mechanism analysis (competitive / uncompetitive / non-competitive, Ki). Fits the MM equation by nonlinear regression (and reports Lineweaver-Burk for reference). Use when you have substrate concentrations and initial reaction velocities and need kinetic parameters or to classify an inhibitor. NOT for BRENDA database lookups of published constants (use the BRENDA tools).

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Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.

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Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.

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Design security-conscious interfaces that protect users without frustrating them. Use when the user asks about MFA, password UX, breach notifications, trust indicators, secure forms, account recovery, or making security feel safe rather than scary.

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Clarify priority and emphasis by fixing unclear primary actions, competing visual weight, loud section titles, and weak label/value treatment. Use when the user mentions hierarchy, prioritization, too much competition, grayscale confusion, loud headings, or unclear primary actions.

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Add or refine depth through elevation systems, raised and inset surfaces, layered overlap, and meaningful shadow behavior so interfaces feel structured instead of flat. Use when the user mentions depth, elevation, shadows, layering, flat cards, pressed states, drag feedback, or inset controls.

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Simplify cluttered UI by removing unnecessary elements, choices, features, and structural complexity. Use when the problem is too many controls, options, features, or competing elements—not when the structure is sound and the real issue is only visual intensity or lack of personality.

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Design, structure, or improve form interfaces for clarity, completion rates, and user confidence. Use when the user asks to build a form, redesign a form flow, improve form conversion, add multi-step forms, fix form UX, or structure field layouts and validation.

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Improve UX writing, marketing copy, labels, microcopy, instructions, and error messages so interfaces and product messaging are easier to understand and act on. Use when the user mentions confusing copy, unclear labels, bad error text, weak CTAs, hard-to-follow instructions, or wanting better UX writing.

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Diagnose and fix UI performance across loading speed, rendering, animations, images, and bundle size. Use when the user mentions slow, laggy, janky, performance, bundle size, load time, or wants a faster, smoother experience.

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Improve interface resilience through better error handling, i18n support, text overflow handling, and edge case management, making interfaces robust and production-ready. Use when the user asks to harden, make production-ready, handle edge cases, add error states, or fix overflow and i18n issues.

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Reduce visual intensity, saturation, and noise while preserving hierarchy and character. Use when the structure is basically sound but the design feels too loud, bold, garish, aggressive, or overstimulating—not when the real problem is structural clutter, too many features, or not enough personality.

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Design charts, metrics, and data tables that help users interpret and compare data. Use when the user asks to visualize data, choose chart types, improve dashboard analytics, or make data presentation accessible. Dashboard navigation and shell layout alone belong to add-ui or arrange.

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Improve how interfaces use photos, screenshots, icons, illustrations, and user-uploaded media so visuals support clarity instead of undermining it. Use when the user mentions images, screenshots, background photos, hero images, icon sizing, user-uploaded media, crops, overlays, or image readability.

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Design focused empty states for zero-data, no-results, permission, and error situations with clear value framing, strong CTAs, and less dead chrome. Use when the user mentions blank pages, zero-data screens, no results, permission states, or dead controls—not broader onboarding strategy.

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Design onboarding and activation flows that help users reach value quickly. Use when the user mentions onboarding, getting started, first-time users, activation, aha moments, or new user flows—not when the work is only the empty-state surface itself.

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Plan, implement, or improve an internationalization and localization strategy for UI content, formatting, and regional adaptation. Use when the user asks to add i18n, localize, translate, support multiple languages, handle regional formats, manage locale switching, or build a multilingual product.

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Improve UI typography by fixing font choices, type scale, hierarchy, weight, and readability so text feels intentional. Use when the user mentions fonts, typography, type scale, readability, text hierarchy, or sizing that feels off.

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