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Comprehensive guidance for implementing asynchronous Python applications using asyncio, concurrent programming patterns, and async/await for building high-performance, non-blocking systems.

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Build anomaly detection applications with Azure AI Anomaly Detector SDK for Java. Use when implementing univariate/multivariate anomaly detection, time-series analysis, or AI-powered monitoring.

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Clarify requirements before implementing. Use when serious doubts arise.

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Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

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Queries PharmGKB / CPIC / DPWG for drug-gene interactions; calls CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles and phenotype with PharmCAT, Cyrius (CYP2D6 structural variants), Aldy, Stargazer; applies Caudle 2020 activity-score translation. Use when implementing pharmacogenomic-guided prescribing, applying CPIC vs DPWG guidance, screening HLA risk alleles for ICI / antiepileptics / abacavir, or interpreting compound TPMT+NUDT15 thiopurine risk.

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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Use this skill when implementing or renewing supervisor reasonable-suspicion training. Covers the 60-minute alcohol + 60-minute drug training requirement, recordkeeping, and refresher cadence.

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Design error handling strategies for TypeScript and Python applications — exception hierarchies, Result/Either types, retry patterns, error boundaries, and structured error logging. Use when designing error handling architecture, choosing between exceptions and Result types, implementing retry logic, or building error recovery flows. Activate on "error handling", "exception hierarchy", "Result type", "retry pattern", "circuit breaker", "error boundary", "Pokemon exception". NOT for debugging specific runtime errors, logging infrastructure setup, or monitoring/alerting configuration.

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Create and review Cloudflare Durable Objects. Use when building stateful coordination (chat rooms, multiplayer games, booking systems), implementing RPC methods, SQLite storage, alarms, WebSockets, or reviewing DO code for best practices. Covers Workers integration, wrangler config, and testing with Vitest. Biases towards retrieval from Cloudflare docs over pre-trained knowledge.

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Implementing distributed tracing with W3C Trace Context — the byte-precise `traceparent` and `tracestate` header formats, OpenTelemetry's W3CTraceContextPropagator as the modern default (replacing X-B3-* and X-Datadog-*), head vs tail sampling, and HTTP→SQL trace propagation via sqlcommenter. Grounded in the W3C REC and OpenTelemetry specs. NOT for OTel metrics/logs pipelines, vendor backend setup (Datadog/Honeycomb/Jaeger/Tempo), or browser RUM tracing.

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Chooses and designs developer surfaces for an agentic product: SDK, CLI, MCP, GUI, API, webhooks, and pd tube-style listener/sender workflows. Use when deciding why a user belongs in an SDK versus CLI/MCP/GUI, planning Python SDK parity, or making agent invocation easy across languages. NOT for implementing the full SDK, generic API docs, or UI visual design.

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Handle mental health crisis situations in AI coaching safely. Use when implementing crisis detection, safety protocols, emergency escalation, or suicide prevention features. Activates for crisis keywords, safety planning, hotline integration, and risk assessment.

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Render mathematically-faithful Turkish marbling (Ebru) and paper-marbling with closed-form coordinate-deformation maps — a drop is a radial outward push, a comb/tine is a decaying shear, all composed as homeomorphisms over colored region boundaries. No fluid solver, runs 60fps on a 2D canvas. Use when building a marbling/Ebru toy or generative-art renderer, implementing drop/comb/wave/swirl deformations, scripting traditional patterns (Battal, Gel-Git, Şal, Bülbül Yuvası), keeping combed edges crisp via adaptive resampling, modeling ox-gall shouldering for crisp ring-in-ring drops, or exporting high-DPI marbled prints. NOT for real fluid / Navier-Stokes simulation, metaball / alpha-blended "smoke" blob effects, raster image-processing filters, or non-marbling generative art.

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Runs an iterative, conversational product-discovery process with a founder/stakeholder: structured interview, live low-fi wireframing, a linked feature/page node-graph built up as you go, a founder-confirmed lock-in checkpoint, then a generated PRD, a Mermaid-rendered sitemap, and a mockup with a full design system (palette, typography, dark mode). Use when building or operating an AI product-discovery chatbot, or when running founder/stakeholder discovery by hand and you need the structure (interview script, node-graph schema, PRD template, design-system handoff order). NOT for implementing the spec'd product once locked — hand off to feature-specific skills (ideal-web-app-builder, tailwind-v4-expert, color-theory-palette-harmony-expert, typography-expert, dark-mode-design-expert) for that. NOT for one-shot PRD generation without an interview loop — if the founder already has a written spec, this process is unnecessary overhead.

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Design multi-tier caching architectures for web applications — cache-aside vs write-through vs write-behind, TTL design, cache invalidation, Redis patterns, CDN configuration, browser caching, and stampede prevention. Use when choosing a caching pattern, designing cache invalidation strategies, implementing Redis caching, configuring Cache-Control headers, or preventing cache stampedes. Activate on "cache invalidation", "cache-aside", "write-through", "TTL", "Redis cache", "CDN caching", "cache stampede", "stale data", "browser cache". NOT for database query caching within an ORM, memoization of pure functions, or CPU-level caching.

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Research AI coding assistant products, audiences, user stories, social proof, hacks, and unmet needs for apps like Cursor, Claude Code, Codex, Warp Code, Devin, Windsurf, GitHub Copilot, Cline, Aider, and homegrown agent stacks. Use when designing or positioning agentic developer tools, Port Daddy Agent Harbor, swarm consoles, background coding agents, or competitive/product research for AI software engineering. NOT for implementing the coding agent runtime, generic market research, or UX mockups without developer workflow evidence.

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Plan, evaluate, and adopt agent infrastructure for a named workload. Use for agent runtime/framework selection, agent evaluation or observability plans, memory and tool boundaries, infrastructure cost controls, and organizational adoption. Covers workload-first comparison, risk and recovery planning, held-out evaluation, cost accounting, and staged rollout. Not a vendor ranking or a production certification. NOT for implementing a specific agent behavior (agentic-patterns), building a specific agent (ai-engineer), prompt optimization (prompt-engineer), or conventional ETL workflow design (jury_rig-architect).

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Implement tasks from an OpenSpec change. Use when the user wants to start implementing, continue implementation, or work through tasks.

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Use when implementing features or fixing bugs with strict Test-Driven Development (TDD). Activate for coding tasks that require new functionality, refactoring, or comprehensive test coverage, especially when the user mentions TDD or Test Driven Development.

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Apple Human Interface Guidelines for iPad. Use when building iPad-optimized interfaces, implementing multitasking, pointer support, keyboard shortcuts, or responsive layouts. Triggers on tasks involving iPad, Split View, Stage Manager, sidebar navigation, or trackpad support.

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Apple Human Interface Guidelines for Mac. Use when building macOS apps with SwiftUI or AppKit, implementing menu bars, toolbars, window management, or keyboard shortcuts. Triggers on tasks involving Mac UI, desktop apps, or Mac Catalyst.

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Three.js interaction - raycasting, controls, mouse/touch input, object selection. Use when handling user input, implementing click detection, adding camera controls, or creating interactive 3D experiences.

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Apple Human Interface Guidelines for Apple Vision Pro. Use when building spatial computing apps, implementing eye/hand input, or designing immersive experiences. Triggers on tasks involving visionOS, RealityKit, spatial UI, or mixed reality.

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CSS and UI animation patterns for responsive, polished interfaces. Use when implementing hover effects, tooltips, button feedback, transitions, or fixing animation issues like flicker and shakiness.

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