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Connect .NET MAUI screens to application data using XAML or C#. Covers compile-time binding checks, change notifications, value conversion, and fallback displays to help implement bindings and investigate screens that fail to update.
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Guidance for .NET MAUI XAML and C# data bindings — compiled bindings, INotifyPropertyChanged / ObservableObject, value converters, binding modes, multi-binding, relative bindings, fallbacks, and MVVM best practices. USE FOR: setting up compiled bindings with x:DataType, implementing INotifyPropertyChanged or CommunityToolkit ObservableObject, creating IValueConverter / IMultiValueConverter, choosing binding modes, configuring BindingContext, relative bindings, binding fallbacks, StringFormat, code-behind SetBinding with lambdas, and enforcing XC0022/XC0025 warnings. DO NOT USE FOR: CollectionView item templates and layouts (use maui-collectionview), Shell navigation data passing (use maui-shell-navigation), dependency injection (use maui-dependency-injection), or animations triggered by property changes (use .NET MAUI animation APIs).
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Look up compound–target binding data in BindingDB using PDB or UniProt identifiers, or search for similar chemical structures. Receive concise summaries of matching records, with full API responses saved to a file when requested.
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Customize Claude Code keyboard shortcuts while preserving existing settings. Change submission keys, add chords—shortcuts entered as a sequence of keystrokes—and remove default bindings, with checks for invalid settings and terminal or operating system conflicts.
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Predict the structure and binding of one defined protein, RNA, DNA, or ligand complex with Boltz. The workflow covers cost confirmation, job submission, result downloads, and summaries of structure and binding metrics.
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Generate candidate positions and orientations for small molecules binding to proteins with DiffDock and DiffDock-L. Prepare single or batch docking runs, organize predicted poses by model confidence, and review validation needs without treating confidence as binding affinity.
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Add or modify Tauri commands in the screenpipe desktop app and regenerate TypeScript bindings, the code connecting frontend calls to Rust handlers. Follow the required annotations and checks to keep both sides consistent.
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Diagnose why GKE Pods cannot authenticate to Google Cloud APIs. Inspect cluster settings, service account bindings, resource permissions, and metadata server health, then provide evidence and concrete fixes for a human to apply.
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Add light and dark modes or custom color themes to .NET MAUI apps. Covers following system settings, switching themes while the app runs, and saving each user's preferred theme.
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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
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Precise knowledge on the binding sites of an RNA-binding protein (RBP) is key to understand (post-) transcriptional regulatory processes. Here we present a workflow that describes how exact binding sites can be defined from iCLIP data. The package provides functions for binding site definition and result visualization. For details please see the vignette.
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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
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Builds and audits a concept-ontology for a regelrecht corpus to decide and verify reference types — cross-law source-binding vs intra-law source-binding vs open-norm leaf vs external-fact leaf — and to catch concept conflation across laws. Core principle: a value's reference type is fixed by WHO derives it, and a binding is sound only when producer and consumer denote the SAME concept; the lexical surface (the word in the text) is not the concept. Detects false friends (one term, different concepts — e.g. a register-based vs a factual "naar de omstandigheden"-based residence/ingezetene concept), orphan plain-params (a value a regulation actually derives, modeled as a brute input), negation/complement re-entry (¬X modeled as an independent leaf next to X), and duplication (one concept re-entered as several independent leafs, losing the single-source-of-truth invariant). Produces a law-level glossary and a stelsel-level concept map with sound same-concept binding edges and flagged lexical-match-but-concept-mismatch edges. Use when deciding whether a value should be cross-law/intra-law/leaf, when the same term means different things across laws, or when a binding might silently conflate concepts.
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Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif database, binding profile, PWM, position weight matrix, TF motif, motif enrichment, motif scanning, binding site prediction.
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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
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Strengthen LDAP and Active Directory services by reviewing encrypted connections, signing, channel binding, access controls, and audit logging. Use the guidance to organize security settings, validate them in a test environment, and document implementation evidence.
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Manage NodeGroup resources in a KubeSphere environment, including creation, updates, and deletion. Bind or unbind nodes, namespaces, and workspaces, verify changes, and investigate synchronization problems or deployment settings using the bundled API script.
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Build or update a Figma design system from existing code. Organize shared colors, spacing, and typography, create reusable components with states and theme bindings, document their use, and check differences between the implementation and Figma.
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Build or update a Figma design system to match a codebase. Organize reusable design values, light and dark themes, component variants, and documentation, then check component structure, appearance, and bindings to those values.
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Create, modify, debug, and review Windows Forms applications while preserving their editable layouts in Visual Studio Designer. Covers resizing, data binding, asynchronous UI behavior, and checks that distinguish successful builds from actual screen and designer verification.
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Generate and screen small-molecule drug candidates with three NVIDIA BioNeMo NIM services. Use GenMol to create molecules, DiffDock to predict how they fit a target protein, and Boltz2 to estimate binding strength and rank candidates.
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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.
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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.
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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.
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