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Fit curves and surfaces interactively with the Curve Fitter app for a complete no-code fitting workflow. Invoke this skill when the Curve Fitter app, cftool, curveFitter, or "curve fitting tool/app" is mentioned in any way. Also use when exploring or comparing fit types (regression, interpolation, smoothing, splines, custom equations); excluding outliers interactively; iterating on a fitting workflow; help choosing a fit type; and exporting to a figure, generating MATLAB code, fits to the workspace, and to Simulink Lookup Tables.

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Nonlinear curve fitting for physics data with proper error propagation, chi-squared analysis, residual diagnostics, confidence intervals, and model comparison (AIC/BIC). Use for any parameter extraction from experimental or simulation data.

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Use when assessing how well a survival model's predicted probabilities agree with observed outcomes by fitting a Cox model and generating bootstrap calibration curves at one or more prediction horizons from a clinical CSV file. NOT for: nomogram construction, univariate Cox screening, ROC analysis, or decision-curve analysis.

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Use when evaluating the clinical utility of a binary prediction model from a single clinical CSV file by fitting a logistic decision-curve model, plotting decision and clinical-impact curves, and exporting summary outputs. NOT for: survival calibration, ROC-only discrimination analysis, nomogram construction, or time-to-event outcomes.

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Bioactivity and small-molecule data-side catalog. Covers ChEMBL search/lookup, MolTrack compound and batch registration, HitTriage / HitDesign / PeptiHit workflows, and Curves dose-response analysis (IC50/EC50 fitting). Open this skill when the user asks about querying ChEMBL, registering or looking up compounds in MolTrack, running a hit-triage campaign, or fitting/inspecting dose-response curves.

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Use this skill when fitting accelerated life models, computing mean time to failure (MTTF), B10 life and similar quantities, fitting life distributions like Weibull for reliability analysis, comparing distribution fits, computing confidence intervals on reliability quantities with bootstrapping, performing lifetime prediction, computing failure rates, plotting Kaplan-Meier curves, computing survival functions, or doing reliability analysis.

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Dose-response / concentration-response curve fitting — IC50, EC50, Hill slope, Emax/Emin efficacy, and relative potency from paired concentration vs response data (enzyme/cell assays, drug screening, agonist/antagonist pharmacology). Fits the 4-parameter logistic (Hill sigmoidal) model. Use when you have concentrations + responses and need a potency value, to compare two compounds' potency, or to judge curve quality. NOT for image-derived dose-response (use tooluniverse-image-analysis) and NOT for survival/regression (use tooluniverse-statistical-modeling).

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Design, implement, and review interface animation, from button feedback to drag gestures. When measurement tools are available, analyze recordings to reconstruct timing, easing—how speed changes—and spring motion, then produce code and an implementation specification.

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• Adding motion to buttons, menus, and dialogs
• Recreating an interface animation from a recording
• Investigating sluggish or jerky motion

This skill should be used when user asks to "improve my mAP", "why is my model overfitting", "my training is diverging", "read my results.csv", "interpret my training curves", "my AP50 is good but AP50-95 is bad", "my recall is low", "how do I pick learning rate", "which augmentations should I use", "should I use a bigger model", "tune hyperparameters", or asks how to train YOLO26 for detection, instance or semantic segmentation, pose, OBB, classification, or depth.

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Think and work like an expert Fire Protection Engineer. Use when a task calls for Fire Protection Engineer judgment. Reasons from NFPA 13 Hazen-Williams hydraulics (K-factor, remote area, hose stream) and NFPA 101 egress (occupant load, travel distance, capacity factors) through NFPA 92 smoke containment/management, ASET/RSET PBD, and FDS/CFAST/CONTAM/PyroSim modeling while treating breached compartmentation, C-factor/fitting errors, and supply-curve shortfall as first-class failure modes.

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Dose-response modeling — EC50 estimation, curve fitting, synergy analysis, and benchmark-dose methods.

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