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Sort out other people's expectations from actual commitments, reflect on anger, and review living costs against income. This skill helps you examine personal boundaries and the financial room needed to turn down unwanted work.
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Patent research and IP landscape: prior-art search, claim mapping, landscape analysis, and freedom-to-operate. Use when conducting a prior-art search, mapping an IP landscape, evaluating patentability, or running an FTO analysis.
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Applies the existentialist and feminist philosophy of Simone de Beauvoir, French philosopher and author of The Second Sex. Reach for this skill whenever the user is grappling with existential dilemmas, moral ambiguity, gender dynamics, societal expectations, or relationship ethics. Trigger this skill for questions about freedom versus responsibility, bodily autonomy, marginalization, or when the user feels trapped by external labels or "immanence." Use this to help the user reclaim their agency, recognize the social construction of their situation, and make authentic choices that expand their transcendence while respecting the interconnected freedom of others.
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Find out whether a chemical series is already claimed, using SureChEMBL's patent-extracted compound corpus and, where a key is available, PatentsView for legal status and assignee history. Use this skill to trace a structure to the patent documents that disclose it, survey an assignee's filings around a target, and understand what the freedom-to-operate question requires that a structure search cannot answer. Also trigger on SureChEMBL, patent chemistry, Markush structure, freedom to operate, composition of matter, assignee, priority date, patent family, or PatentsView.
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Map the intellectual property landscape for a technology domain or product area. Covers patent cluster analysis, white space identification, competitor IP portfolio assessment, freedom-to-operate preliminary screening, and strategic IP positioning recommendations. Use before starting R&D in a new technology area, when evaluating market entry against incumbents with strong patent portfolios, preparing for investment due diligence, informing a patent filing strategy, or assessing freedom-to-operate risk for a new product.
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Generate website design references as separate horizontal images for each section. Keep a consistent palette while varying layouts, spacing, imagery, and calls to action, giving developers or coding agents concrete visual references for implementation.
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Generate separate horizontal design reference images for each section of a landing page or marketing website. It coordinates colors, typography, imagery, spacing, and action buttons while varying layouts to give developers a concrete visual guide.
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Explore career choices, business opportunities, and competing goals using frameworks drawn from Naval Ravikant’s public work. Examine how software or content can multiply effort, identify distinctive knowledge, and clarify what wealth and freedom mean for a decision.
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Edit videos through conversation, from transcription and take selection to cuts, color adjustments, animated overlays, and subtitles. Confirm an editing plan, review a checked preview, and refine the result before the final render.
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Evaluate everyday tasks using a deliberately high personal hourly rate. Review weekly activities, identify tasks to delegate or drop, and examine whether rising spending is keeping you from having more control over your time.
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Prepare an initial review of patents that might affect a product launch. Compare product features with individual patent claim elements, record uncertainties and search limits, and produce a memo for patent counsel. It does not determine launch clearance.
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Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.
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Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra. Covers database searching, spectral library matching, and FDR estimation using target-decoy approaches.
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Supervised and unsupervised multi-omics integration with mixOmics. Includes sPLS for pairwise integration and DIABLO for multi-block discriminant analysis. Use when performing supervised multi-omics integration or identifying features that discriminate between groups.
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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.
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Post-translational modification analysis including phosphorylation, acetylation, and ubiquitination. Covers site localization, motif analysis, and quantitative PTM analysis. Use when analyzing phosphoproteomic data or other modification-enriched samples.
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Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequences. Use when FastQC shows adapter contamination or before alignment of short reads.
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Modify protein structures using Biopython Bio.PDB. Use when transforming coordinates, removing atoms or residues, adding new entities, modifying B-factors and occupancies, or building structures programmatically.
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Data-independent acquisition (DIA) proteomics analysis with DIA-NN and other tools. Use when analyzing DIA mass spectrometry data with library-free or library-based workflows for deep proteome profiling.
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All-in-one read preprocessing with fastp including adapter trimming, quality filtering, deduplication, base correction, and HTML report generation. Use when preprocessing Illumina data and wanting a single fast tool instead of separate Cutadapt, Trimmomatic, and FastQC steps.
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Build, manage, and search spectral libraries for proteomics. Use when creating or working with spectral libraries for DIA analysis. Covers DDA-based library generation, predicted libraries (Prosit, DeepLC), and library formats.
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Enumerates chemical libraries through reaction SMARTS transformations using RDKit. Generates virtual compound libraries from building blocks using defined chemical reactions with product validation. Use when creating combinatorial libraries or enumerating products from synthetic routes.
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Parse and write protein structure files using Biopython Bio.PDB. Use when reading PDB, mmCIF, and MMTF files, downloading structures from RCSB PDB, or writing structures to various formats.
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Gene Set Enrichment Analysis using clusterProfiler gseGO and gseKEGG. Use when analyzing ranked gene lists to find coordinated expression changes in gene sets without arbitrary significance cutoffs. Detects subtle but coordinated expression changes.
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