仕事効率化のスキル

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al. 2023), Pharmer / Pharmit for search, and PharmacoForge for protein-pocket-conditioned pharmacophore generation (Flynn et al. 2025), covering ligand-based pharmacophores from active-set alignment and receptor-based pharmacophores from binding-pocket geometry. Explicitly handles feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Installs 425 bioinformatics skills covering sequence analysis, RNA-seq, single-cell, variant calling, metagenomics, structural biology, and 56 more categories. Use when setting up bioinformatics capabilities or when a bioinformatics task requires specialized skills not yet installed.

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Use when building ANY watchOS app — app structure, independent apps, Watch Connectivity, Smart Stack widgets, complications, controls, RelevanceKit, background tasks, ClockKit migration.

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Use when an Apple-platform app feels slow, memory grows, battery drains, or ANY performance issue needs diagnosing. Covers memory leaks, profiling, Instruments workflows, retain cycles, optimization.

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Build direct Bluetooth Low Energy workflows with Core Bluetooth. Use when implementing BLE central or peripheral GATT communication, scanning or connecting with CBCentralManager, discovering services and characteristics, reading/writing/subscribing with CBPeripheral, publishing local services with CBPeripheralManager, handling Bluetooth authorization, background BLE modes, state restoration, write flow control, or CBUUID-based workflows. For privacy-preserving accessory setup/picker flows, use accessorysetupkit first and return here for post-setup GATT communication.

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Schedule and execute background work on iOS using BGTaskScheduler. Use when registering BGAppRefreshTask for short background fetches, BGProcessingTask for long-running maintenance, BGContinuedProcessingTask (iOS 26+) for foreground-started work that continues in background, background URLSession downloads, or background push notifications. Covers Info.plist configuration, expiration handling, task completion, and debugging with simulated launches.

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Create, read, and manage calendar events and reminders using EventKit and EventKitUI. Use when adding events to the user's calendar, creating reminders, setting recurrence rules, requesting calendar or reminders access, presenting event editors, choosing calendars, handling alarms, observing calendar changes, or working with EKEventStore, EKEvent, EKReminder, EKCalendar, EKRecurrenceRule, EKEventEditViewController, EKCalendarChooser, or EventKitUI views.

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Optimize MongoDB client connection configuration (pools, timeouts, patterns) for any supported driver language. Use this skill when working/updating/reviewing on functions that instantiate or configure a MongoDB client (eg, when calling `connect()`), configuring connection pools, troubleshooting connection errors (ECONNREFUSED, timeouts, pool exhaustion), optimizing performance issues related to connections. This includes scenarios like building serverless functions with MongoDB, creating API endpoints that use MongoDB, optimizing high-traffic MongoDB applications, creating long-running tasks and concurrency, or debugging connection-related failures.

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Build and validate experimental WebMCP tools for an existing web page. Use when an agent needs to expose a site's real workflows as page tools, create webmcp.init.js, define deterministic checks, or compare WebMCP with accessibility-tree automation.

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Trigger when: (1) User mentions "manimgl" or "ManimGL" or "3b1b manim", (2) Code contains `from manimlib import *`, (3) User runs `manimgl` CLI commands, (4) Working with InteractiveScene, self.frame, self.embed(), ShowCreation(), or ManimGL-specific patterns. Best practices for ManimGL (Grant Sanderson's 3Blue1Brown version) - OpenGL-based animation engine with interactive development. Covers InteractiveScene, Tex with t2c, camera frame control, interactive mode (-se flag), 3D rendering, and checkpoint_paste() workflow. NOT for Manim Community Edition (which uses `manim` imports and `manim` CLI).

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Smart triggered RF capture on NI USRP radios with Wireless Testbench — record only when a signal of interest appears, not continuously (triggered spectrum sensing). Use energy detection to capture when signal power rises above the noise floor, or preamble detection to cross-correlate against a known sequence (WLAN L-LTF, 5G NR PSS/SSS, LTE PSS, Zadoff-Chu, custom protocols) and capture only when that protocol's preamble is detected. Use when implementing triggered (wake-on-signal) capture or spectrum sensing, capturing protocol-based signals via cross-correlation, calibrating detection thresholds (plotDetectionSignals / plotThreshold), scanning frequency bands for activity, or building transmit-then-detect workflows.

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Plan manipulator motion and generate trajectories in MATLAB. Use when the task involves moving a robot arm between configurations or poses — whether the user says "trajectory," "motion," "path," "move from A to B," or "plan." This skill applies regardless of whether the user explicitly mentions collisions or obstacles; if geometry exists in the workspace, collision safety is implicit. Triggers on: manipulatorRRT, manipulatorCHOMP, dlCHOMP, contopptraj, trapveltraj, collision-free path, motion planner, RRT, CHOMP, TOPPRA, path shortening, obstacle avoidance for manipulators, time-optimal trajectory, velocity limits, acceleration limits, occupancyMap3D, meshtsdf, collision objects as environment, trajectory between waypoints, joint interpolation, move between poses, constant velocity, trapezoidal profile, feed rate. Also triggers when a user has IK solutions or waypoints and needs to connect them — whether for time-optimal motion, constant-speed welding/cutting, or any other trajectory parameterization.

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Guides the 7-step MATLAB memory optimization workflow: baseline, profile, identify, optimize, measure, verify, report. Use when asked to reduce MATLAB memory usage, find memory bottlenecks, fix out-of-memory errors, or optimize memory-intensive code.

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Read BEFORE optimizing any MATLAB code for speed. Without this workflow, agents commonly optimize the wrong target, fabricate speedup claims without measurement, or introduce regressions. Guides the 7-step workflow: baseline, profile, identify, optimize, measure, verify, report.

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Foundation skill for all RoadRunner workflows: MATLAB path setup, connection, project/scene/scenario lifecycle, world settings, handle management, status, and close. Use when connecting to RoadRunner, managing projects/scenes/scenarios, setting world origin, checking status, closing RoadRunner, or when any downstream RoadRunner skill needs initialization.

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Email automation flows — welcome series, abandoned cart, post-purchase, win-back, browse abandonment

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Write and debug ast-grep rules for structural code search and rewrite. Use when tasks require AST-aware matching (not plain text), such as finding specific syntax shapes, relational patterns (inside/has), composite logic (all/any/not), or precise code refactors across a codebase.

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Set up OpenClaw locally and run it reliably on a Mac mini for private, always-on local agent workflows.

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Implement Git branching strategies, PR workflows, and release management patterns. Configure GitFlow, trunk-based development, or GitHub Flow for team collaboration. Use when establishing version control workflows or improving development team collaboration.

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Automate versioning and changelog generation using semantic versioning principles. Configure release automation, version bumping, and changelog tools. Use when implementing version management or automating release processes.

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Conduct periodic access reviews and certifications. Implement access governance and recertification workflows. Use when managing access compliance.

日本語の概要は準備中です。原文の説明を表示しています。