AIPOCH

Generate Baujat plots for heterogeneity analysis. Identify studies that contribute most to the overall meta-analysis results and heterogeneity, helping discover potential outlier studies. Input meta-analysis data CSV, output Baujat plot PNG and contribution data CSV.

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Process, clean, and compare mass spectrometry (MS/MS) spectra with Matchms; use when you need reproducible spectral filtering and similarity scoring for metabolomics workflows.

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Assist in drafting professional peer review response letters. Trigger.

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Generate NIH Biosketch documents compliant with the 2022 OMB-approved.

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Use Bio.Phylo to read/write phylogenetic trees and perform visualization and statistics; use when tree parsing/conversion, pruning/rerooting, distance calculation, or plotting is required.

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Use Biopython to read/write/convert biological sequence files (FASTA/GenBank/FASTQ, etc.) and perform basic sequence operations; use when you need reliable sequence I/O, lightweight sequence manipulation, or scalable processing of large sequence datasets.

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Interpret Alpha and Beta diversity metrics from 16S rRNA sequencing results.

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Orchestrates a systematic review and meta-analysis workflow following PRISMA 2020 guidelines, from protocol development through multi-database search, screening, data extraction, and evidence synthesis. Use when conducting evidence-based reviews, meta-analyses, or scoping revi...

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Analyzes forest plots for meta-analysis, generating detailed descriptions and formatting figure legends in Chinese or English. Use when the user wants to interpret a forest plot image, describe its statistical significance (heterogeneity, p-value), and format the output with s...

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Use this skill when converting academic papers to promotional and presentation formats, including interactive websites (Paper2Web), presentation videos (Paper2Video), and conference posters (Paper2Poster). This skill is suitable for paper dissemination, conference preparation, creating explorable academic homepages, generating video abstracts, or producing printable posters from LaTeX or PDF source.

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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular...

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Advanced Biopython modules for motifs, population genetics, sequence utilities, restriction analysis, clustering, and GenomeDiagram visualization; use when you need extended bioinformatics analysis beyond basic sequence I/O and alignment.

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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...

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Data structure for annotated matrices in single-cell analysis; use when reading/writing .h5ad (or zarr) and exchanging data with the scverse ecosystem.

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Sequence alignment and alignment file processing with Biopython (Bio.Align/Bio.AlignIO), triggered when you need global/local pairwise alignment, MSA read/write/format conversion, or alignment statistics/filtering.

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Prepare FDA/EMA regulatory submissions (IND/NDA/BLA/510(k)/PMA/MAA) in CTD format. Generate module outlines (Modules 1-5), run ICH compliance checks (ALCOA+, E6 GCP, Q1-Q12), verify data integrity, and produce submission-ready dossiers with cover letters and checklists.

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Generate USMLE Step 1/2 style clinical cases with patient history, physical.

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Generates a Meta-analysis results section description for funnel plots, including statistical tables (Egger's, Begg's, Trim & Fill) and figure legends. Supports English and Chinese outputs. Use when user provides a funnel plot image and statistics and wants a formatted report.

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Generate a complete NSFC (National Natural Science Foundation of China) General Program grant application in Chinese, following the 2026 official template. Use when the user provides a scientific hypothesis and wants to generate a full grant application document, including abs...

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Helps organize reviewer comments and generate a standardized Word (.docx) response letter that maps each change to its exact location (page/paragraph/line). Use when revising a manuscript, replying to peer-review feedback, or preparing internal review responses.

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Conduct professional peer reviews for papers or theses, providing structured evaluations and improvement suggestions; use when you need a pre-submission assessment, an internal review, or academic quality control.

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Use when creating radiology educational quizzes, preparing board exam questions, or studying medical imaging cases. Generates interactive quizzes with X-ray, CT, MRI, and ultrasound images for medical education.

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Use rebuttal letter strategist for academic writing workflows that need structured execution, explicit assumptions, and clear output boundaries.

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Generates detailed text descriptions of medical images and charts for.

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