127 skills · sorted by relevance
Implement and review React, React Native, and TypeScript interfaces to reduce unnecessary rendering. It guides state placement, Hook dependencies, and memoization—reusing calculations or components—with performance checks that preserve correct screen updates.
构建目标受众画像：分析粉丝人群特征、痛点需求、内容偏好和触达渠道，输出可执行的受众画像卡。 当用户说"受众画像""粉丝画像""我的用户是谁""目标人群""用户痛点""受众分析""谁在看我"时使用。 构建的是受众/粉丝画像，创作者自己的声音画像用 skill-voice-builder。
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创作者/品牌入驻：通过结构化访谈收集视觉风格、内容调性、受众画像和运营目标，生成完整的账号画像档案。 当用户说"账号入驻""建档案""新账号建立画像""品牌入驻""从零建号""完善账号信息""onboarding"时使用。 产出覆盖多维度的完整账号档案；只建声音画像用 skill-voice-builder，只建受众画像用 skill-audience-profiler。
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KEGG pathway and module enrichment analysis using clusterProfiler enrichKEGG and enrichMKEGG. Use when identifying metabolic and signaling pathways over-represented in a gene list. Supports 4000+ organisms via KEGG online database.
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Gene Set Enrichment Analysis using clusterProfiler gseGO and gseKEGG. Use when analyzing ranked gene lists to find coordinated expression changes in gene sets without arbitrary significance cutoffs. Detects subtle but coordinated expression changes.
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Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.
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Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression or other analyses. Supports all three ontologies (BP, MF, CC), multiple ID types, and customizable statistical thresholds.
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WikiPathways enrichment using clusterProfiler and rWikiPathways. Use when analyzing gene lists against community-curated open-source pathways. Performs over-representation analysis and GSEA for 30+ species.
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Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
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Use when the user asks to "build the norm card for this platform", "what are the char limits and visible-fold cutoffs here", "is the LinkedIn link-in-first-comment thing documented or folklore", or "which of our platform cards are stale"; maintains the dated, versioned per-platform norm cards in the references/platforms/ pack — char limits, visible-fold cutoffs, hashtag norms, format/aspect specs, link and first-comment placement, disclosure-label mechanics, algorithm emphases (e.g. 小红书 search+saves weighting) — every row labeled platform-documented (official doc, Measured) or Estimated-folklore (named source) with last-verified and review-by dates, and any card past its review date flagged stale rather than trusted. Extends the single pack in place; never forks a second one. Not for picking which channels to run — use channel-portfolio-planner. 平台规范卡/字符限制/折叠线/话题标签/算法侧重/过期标记
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Debug and profile Three.js browser games: blank canvases, render and runtime bugs, asset and audio loading, animation, resize, mobile input, plus performance profiling of draw calls, triangles, textures, memory, shader and post-processing cost, and bundle size.
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Use when profiling CPU/memory hot paths, generating flame graphs, or capturing JFR/perf evidence.
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Profile code performance and identify bottlenecks
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Profile and optimize Python code using cProfile, memory profilers, and performance best practices. Use when debugging slow Python code, optimizing bottlenecks, or improving application performance.
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Attribute GPU time in one sglang-omni stage to specific lines of `sglang_omni/` python source. Drives the `llm-torch-profiler-analysis` backend with a mapping/formal trace pair plus steady-state gates, and carries the rules for reading its three tables on an omni stage. Use when a stage is slower than expected and the question is which python code is the bottleneck, not which kernel is hot.
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Segment single cells from multiplexed IMC/MIBI tissue images using Mesmer/DeepCell, Cellpose, or ilastik+CellProfiler, covering whole-cell vs nuclear segmentation, the summed-membrane-channel decision, nuclear-expansion bias, lateral spillover, resolution-floor parameters, and downstream-proxy evaluation. Use when delineating cells after preprocessing, choosing a segmentation model, building a cell mask for quantification, diagnosing impossible double-positive populations, or troubleshooting over/under-segmentation.
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Assigns isolate identity at the right resolution for the question -- ANI/Mash species triage, 7-locus MLST historical comparability, cgMLST/wgMLST outbreak resolution (chewBBACA, BIGSdb, Ridom SeqSphere, EnteroBase HierCC), in-silico serotyping (SISTR/SeqSero2 Salmonella, SerotypeFinder E. coli, Kaptive Klebsiella, SeroBA pneumococcus, spa+SCCmec S. aureus), and lineage callers (TB-Profiler/Mykrobe barcode for MTBC, Pangolin + Nextclade for SARS-CoV-2, PopPUNK GPSC for S. pneumoniae). Use when typing bacterial isolates for surveillance or outbreak investigation, choosing between cgMLST allele distance and core-SNP distance for cluster definition, harmonising calls across schemas/database versions, assigning MTBC lineage with the Napier 90-SNP barcode, calling Salmonella serovar via SISTR with monophasic Typhimurium awareness, running Pangolin UShER mode with pangolin-data version pinning, or selecting a typing resolution to match the surveillance question.
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Detects acquired antimicrobial-resistance determinants and chromosomal point-mutation resistance in bacterial assemblies using AMRFinderPlus, ResFinder 4.0 (acquired + PointFinder), CARD-RGI, abritAMR, staramr, and species-specific callers (TB-Profiler, Mykrobe). Harmonises cross-tool output via hAMRonization, contextualises determinants with mobile-genetic-element annotation (MOB-suite, PlasmidFinder, MobileElementFinder, ICEberg), predicts phenotype against EUCAST or CLSI breakpoints, and translates calls into WHO GLASS reporting categories. Use when screening clinical or surveillance isolates for AMR, distinguishing acquired vs intrinsic vs point-mutation resistance, calling rpoB / katG / pncA / gyrA / mgrB mutations, reconciling AMRFinderPlus vs RGI vs ResFinder disagreement, contextualising carbapenemases or mcr alleles on plasmids, predicting susceptibility from genotype against the WHO Mtb 2nd-edition catalogue, or building a hAMRonized multi-lab AMR surveillance pipeline.
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Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
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Performance profiling for Node.js, Python, and Go: CPU flamegraphs, memory leak detection, bundle analysis, query optimization, and k6 load testing. Use when diagnosing slow endpoints, memory growth, large bundles, or traffic spikes.
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DNA sequence profiling and genetic variant characterization
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Expert multiplayer for desync, rollback, dedicated --headless servers, interest culling, and bandwidth spikes: ENet/WebRTC choice, authority, secure RPCs, client prediction/reconcile, and adaptive sync. Trigger on rubber-banding, cheat-able clients, peer floods, late join, or profiler Network spikes — not only greenfield online games. Keywords: multiplayer, RPC, ENetMultiplayerPeer, MultiplayerSynchronizer, authority, client prediction, rollback, interest management, headless, desync.
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Use when optimizing Godot games — profiler, draw calls, physics tuning, memory management, and common bottlenecks
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Use when writing production-grade GDScript — performance idioms, metaprogramming, @tool lifecycle, async pitfalls, signal/Callable trade-offs, profiler-driven idioms, and common pitfalls
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