109 skills · sorted by relevance
Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
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Use when designing, evaluating, documenting, modernizing, reviewing, refactoring, or implementing software architecture and code-level structure, including requirements, context, architecture style selection, microservices patterns, WebAssembly/WASI/Component Model, UMA portable capabilities, runtime contracts, capability graphs, governed MCP/agent orchestration, clean code, code smells, Rust crate/library API architecture, Cargo feature/MSRV/SemVer policy, unsafe/FFI/no_std/library testing, modularity, views, NFR tactics, IAM/auth, security patterns, cost estimation, architecture-as-code fitness functions, ADR/RFC work, and engineering execution plans.
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SharedPreferences (v2.5.5) for Flutter providing simple persistent key-value storage for non-sensitive user settings and app preferences. Use this skill when storing user preferences (theme mode, language selection, font size), app settings and configuration, feature flags or A/B test assignments, simple cache data, onboarding completion status, last selected values (filters, sort options), user consent flags, or any non-sensitive data that survives app restarts. Supports String, int, double, bool, and StringList types. NOT suitable for storing tokens, passwords, API keys, or any sensitive/encrypted data (use flutter_secure_storage instead). Ideal for quick persistent storage without database overhead.
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PC and console game development principles. Engine selection, platform features, optimization strategies.
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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
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Validates predictive models on omics and biomedical data with nested cross-validation, group/batch/temporal-aware splits, the full data-leakage taxonomy, probability calibration, decision-curve net benefit, optimism correction, sample-size planning, and TRIPOD+AI reporting. Use when estimating model performance honestly, choosing a CV scheme, detecting leakage, or judging whether reported discrimination means the model is actually useful. For feature selection itself see machine-learning/biomarker-discovery; for confirmatory-trial inference see clinical-biostatistics/trial-reporting.
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End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, leakage-safe cross-validation, calibration, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
The English summary is being prepared. Showing the original description.
Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Use when a carrier asks about fuel-card vendor selection (Comdata, EFS, WEX, RTS, Pilot Flying J, Love's Connect), discount levels, fraud control, driver authorization PINs, IFTA reporting features, cash advance, money codes, or how the card fits into payroll/settlement workflows.
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Facilitate idea generation sessions that actually produce diverse, useful options instead of degenerating into the first plausible answer. Use for product ideation, feature exploration, problem-reframing, naming, design alternatives, strategic option-generation, or any task where the failure mode is "we picked the obvious thing too fast." Covers solo and group sessions, divergence/convergence discipline, technique selection (SCAMPER, Crazy Eights, How Might We, 6-3-5 Brainwriting, Reverse Brainstorming, Worst Possible Idea, Random Stimulus), facilitation moves for handling dominant voices and groupthink, and structured convergence to a shortlist with rationale. Outputs a session artifact with options generated, evaluation, shortlist, and the rejected-but-interesting list.
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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
The English summary is being prepared. Showing the original description.