Results for “frequency”

Classify a proposed code change as Leaf Node or Core Code to decide how much AI usage and review rigor is appropriate. Use this skill whenever the user asks "is this leaf or core", "what kind of change is this", "should I vibe code this", "can AI write this", "how rigorous should the review be", or before starting any non-trivial change. Also useful as a sub-step inside other workflows (planning, PR prep, code review) when classification matters. Asks 6 diagnostic questions about propagation range, change frequency, tech-debt tolerance, examples, failure cost, and review intensity, then outputs a clear classification with the recommended approach. Trigger even when the user describes a change without explicitly asking for classification — the answer changes how they should proceed.

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Use when a task needs the judgment of an Automotive Engineer — computing weight transfer and tire friction-circle limits for a braking-while-cornering maneuver to set brake-force distribution, sizing a powertrain and gear ratio against a 0-60 mph acceleration target while checking traction versus power limits, sizing a crumple zone's crush distance against FMVSS 208 occupant-deceleration limits, or checking a powertrain-mount or driveline natural frequency against engine firing-order excitation for NVH isolation. Distinct from an automotive-service-technician (diagnoses and repairs a vehicle already designed) — this role owns the system-level design decisions (structure, powertrain sizing, suspension geometry, restraint/crash structure, NVH) that produce the vehicle the technician later services.

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Use when a task needs the judgment of a Biomass Plant Technician — adjusting combustion parameters in response to actual measured fuel moisture content rather than a fixed setpoint, diagnosing a fuel feed interruption as mechanical bridging rather than a combustion issue, adjusting soot-blowing frequency to actual observed slagging conditions rather than a fixed calendar schedule, or monitoring emissions more actively given fuel batch variability rather than a "set and monitor occasionally" approach appropriate for consistent fossil fuel.

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Use when a task needs the judgment of an animal trainer — designing a behavior-modification plan for a specific problem behavior, choosing a reinforcement schedule and deciding when to raise criteria, structuring session length and frequency to avoid fatigue or frustration plateaus, or setting a handler/public safety protocol around a training animal.

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Diagnoses and prevents vbar_control_agent segfaults, out-of-memory (OOM) errors, and TPU device initialization failures on TPU v6e nodes in GKE caused by race conditions during TPU device resets or high-frequency metrics polling. Use when troubleshooting vbar_control_agent crashes, memory cgroup OOMs in serial console logs, tpu-device-plugin metrics checksum corruption errors, or custom TPU metrics collection conflicts on GKE TPU v6e nodes. Don't use for general non-TPU container OOM troubleshooting or standard GKE node lifecycle operations.

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Catalog-then-fix slop removal on an existing prose draft. Parallel catalog subagents inventory four slop categories (theatrics, overwrought register, corrective antithesis, dramatic short sentences), fix subagents repair only what a catalog names, mechanical lint + frequency analysis bracket the run, and a regression gate (lint delta, word count, cold meaning check) decides whether the result ships. Use when the user says "deslop this draft", "catalog deslop", "strip the AI patterns from this file", or as the final stage of the article-factory and mosaic-writing skills. For writing or redrafting prose from scratch, use the prose skill instead - this skill only repairs an existing draft in place.

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Assemble a finished piece from human-written fragments via an orchestrated two-loop pipeline - an assembly loop (assembler + cold reviewer) that sequences the fragments into a draft, then a polish loop (polisher + cold reviewer), then frequency analysis and a catalog-deslop pass with a regression gate. Two modes with opposite fidelity contracts - stitch mode preserves the author's exact wording, narrative mode preserves every idea but may rewrite freely. Use when the user says "mosaic", "assemble my fragments", "stitch these notes into a post", or provides a fragments file to turn into a finished piece. For writing from a topic with research, use article-factory; for prose from scratch, use the prose skill.

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Build a dated monthly or quarterly editorial calendar: which posts to publish or review when, content mix, templates, distribution timing, and a material-change review queue. Use when the user says "editorial calendar", "content calendar", "publishing schedule", "what should I write this month". Not for positioning or pillars (blog-strategy), SERP-validated cluster maps (blog-cluster), or detecting declining pages from Search Console exports (blog-decay). Publication frequency is not a ranking signal.

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Create and manage writing personas with NNGroup 4-dimension tone framework (Funny-Serious, Formal-Casual, Respectful-Irreverent, Enthusiastic-Matter-of-fact). Personas define readability targets, sentence length distribution, vocabulary tier, contraction frequency, and summary box label. Used by blog-write and blog-rewrite to enforce consistent voice. Use when the user says "create persona", "use persona", "list personas", or wants tone sliders and writing rules saved as structured JSON. Not for measuring style from existing posts (blog-style) or for audience, positioning, and taboo-phrase context files (blog-brand).

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Plan, implement, audit, and review C#/.NET SwiftlyS2 plugins. Use when working with Commands, Core Events, Game Events, GameHooks Pre/Post, raw native hooks, Modules, Workers, Services, high-frequency runtime loops, NetMessages, Schema access, entity handling, thread safety, performance, or IPlayer lifecycle behavior.

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Detects improper use of SKStoreReviewController.requestReview() that violates Guideline 5.6.1 — including prompts triggered by button taps, excessive frequency, or satisfaction gating.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Build sequence logos from aligned DNA, RNA, or protein motifs using ggseqlogo (R), Logomaker (Python), or WebLogo with explicit bits vs probability encoding, background-frequency correction, custom alphabets, and multi-logo stacking. Use when visualizing motif PWMs (TF binding, splice sites, CRISPR spacers), aligned-position composition, or comparing two motif sets.

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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

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Generate consensus FASTA sequences by applying VCF variants onto a reference with bcftools consensus, or build viral/amplicon consensus with iVar. Use when reconstructing a sample-specific reference or haplotype, deciding -H haplotype vs IUPAC vs all-ALT projection, masking no-coverage sites so a consensus does not manufacture false reference calls, or setting iVar min-depth/min-frequency policy for surveillance genomes.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV and AnnotSV for semi-automated scoring. Covers the separate copy-number-loss and copy-number-gain rubrics, the five-tier classification, ClinGen haploinsufficiency/triplosensitivity and dosage-sensitive regions, de novo and segregation evidence, and population-frequency benign evidence. Use when assigning pathogenic/likely-pathogenic/VUS/likely-benign/benign to a constitutional CNV, scoring a CNV against ACMG/ClinGen criteria, or distinguishing the automatable evidence from the case-specific evidence requiring manual input.

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Suggests periodic screening for autoimmune diseases known to be more prevalent in PAI patients in whom autoimmune origin of PAI has not been excluded; optimal frequency unknown but can be done annually. Use when determining screening schedule for PAI patient with uncertain autoimmune origin.

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Decide when to order coronary artery calcium (CAC) scoring in a primary-prevention patient and interpret the result per the 2026 ACC/AHA multisociety dyslipidaemia guideline. Covers the Class 1 indication (men ≥40 / women ≥45, borderline / intermediate PREVENT-ASCVD risk, uncertainty about LLT), CAC score interpretation (0, 1–99, 100–299, ≥300, ≥1000), how CAC modifies LDL and non-HDL goals, when to repeat CAC, and pitfalls (incidental CAC on non-cardiac CT, radiation, cost). Use when a clinician asks should I order a CAC score, CAC indications, what does CAC 150 mean, treatment goals with CAC score, repeat CAC frequency, CAC in a smoker, CAC vs CCTA, is CAC useful in intermediate risk. Grounded in the 2026 ACC/AHA multisociety dyslipidaemia guideline.

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Guides individualised HbA1c target-setting and identifies the correct intensification trigger for adults with type 2 diabetes using the NICE NG28 (2026) framework, covering standard targets, hypoglycaemia-risk adjustment, indications for target relaxation, and appropriate monitoring frequency.

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Suggests using hydrocortisone 15–25 mg or cortisone acetate 20–35 mg daily in two or three divided oral doses for adult primary adrenal insufficiency (PAI) patients initiating glucocorticoid replacement. The highest dose is given upon awakening, with the second dose either early afternoon (≈2 h after lunch) or split into lunch and afternoon doses; consider total daily dose calculation based on chosen formulation and frequency.

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Expert-level control systems engineering covering feedback control, PID design, root locus, frequency domain methods, state-space design, and digital control.

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