Results for “dos”

Recommends hydrocortisone replacement dosing of 15–20 mg total daily, administered as a single dose or divided doses with the highest dose given in the morning upon awakening and the second dose in the afternoon (two-dose regimen) or second and third doses at lunch and late afternoon (three-dose regimen). Use when initiating glucocorticoid replacement for adrenal insufficiency; triggers include diagnosing adrenal insufficiency requiring glucocorticoid replacement.

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Suggests using hydrocortisone 15–25 mg or cortisone acetate 20–35 mg daily in two or three divided oral doses for adult primary adrenal insufficiency (PAI) patients initiating glucocorticoid replacement. The highest dose is given upon awakening, with the second dose either early afternoon (≈2 h after lunch) or split into lunch and afternoon doses; consider total daily dose calculation based on chosen formulation and frequency.

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Review Ant Design GitHub issues and prepare responses, labels, and closure recommendations. It distinguishes bugs from feature requests, checks bot answers, and presents a complete plan for approval before making changes.

• Draft responses to unanswered issues
• Classify bugs and feature requests
• Review dosubot answers

Analyze drug concentration and response data to calculate exposure, fit models of drug movement and effects, and simulate dosing schedules. Produces exploratory research results with explicit assumptions and diagnostic checks.

• Calculate exposure and half-life from concentration data
• Compare models of drug concentration over time
• Simulate dosing schedules for research

Capture tasks and ideas in GSD as structured todos, notes, backlog entries, or future ideas with trigger conditions. You can also browse pending todos, choose work to start, and review previously captured future ideas.

• Saving tasks as structured todos
• Capturing quick notes and promoting them later
• Parking ideas in the backlog

Determines age- and body weight-appropriate glucocorticoid dosage for pediatric patients with primary aldosteronism, particularly glucocorticoid-remediable aldosteronism (GRA), to avoid over-treatment. Use when prescribing glucocorticoids to children with confirmed or suspected PA; triggers include pediatric PA, GRA, or need to dose glucocorticoid based on age and weight.

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Interprets the postural stimulation test to detect angiotensin II‑unresponsive aldosterone‑producing adenoma (APA) or familial hyperaldosteronism type I (FH‑I) when aldosterone fails to rise with upright posture. Triggered by clinical cues such as “postural stimulation test shows no aldosterone increase”, “suspected APA with non‑responsive aldosterone”, or “evaluating FH‑I in young patients with early‑onset hypertension and hypokalemia”.

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Tokenizadores rápidos otimizados para pesquisa e produção. Implementação em Rust que tokeniza 1GB em menos de 20 segundos. Suporta algoritmos BPE, WordPiece e Unigram. Treine vocabulários customizados, rastreie alinhamentos, gerencie padding/truncagem. Integração perfeita com transformers. Use quando precisar de tokenização de alto desempenho ou treinamento de tokenizadores customizados.

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Framework de dados para construir aplicações LLM com RAG. Especializado em ingestão de documentos (300+ conectores), indexação e consultas. Inclui índices vetoriais, mecanismos de consulta, agentes e suporte multimodal. Use para perguntas sobre documentos, chatbots, recuperação de conhecimento ou construção de pipelines RAG. Ideal para aplicações LLM centradas em dados.

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Build clinical decision support for electronic medical records, covering drug interactions, dose validation, clinical risk scores, and alerts. Provides patterns for testable checking functions, severity-based interface behavior, and safety tests that detect missed warnings.

• Implementing drug interaction and allergy checks
• Validating doses using patient factors
• Implementing NEWS2 and other clinical scores

Investigate a username, file, code identifier, URL, or concept by exploring connected entities across relevant sources. Produce a dossier with a summary, relationship diagram, source references, and a machine-readable JSON graph.

• Mapping connections around a username or concept
• Investigating references to a file or code identifier
• Tracing links to an architecture decision record

Organize multi-step agent tasks with persistent Markdown files for plans, findings, and progress. Records decisions, errors, and test results, then reloads the selected task's planning files to resume work after an interruption.

• Planning research that involves many tool calls
• Resuming work after an interruption
• Recording errors and test results

Structured intelligence dossiers on companies, people, markets, or domains, with source triangulation and fact/inference discipline. Use when preparing a deal-prep dossier, executive briefing, or due-diligence overview.

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Orientação LGPD para operações de tratamento no Brasil. Cobre bases legais (Art. 7º e Art. 11), RIPD, incidentes (Arts. 48-49), direitos dos titulares (Art. 18) e transferências internacionais. Triggers: LGPD, RIPD, ANPD, proteção de dados, dados pessoais, consentimento, encarregado, DPO Brasil, incidente de dados, legítimo interesse.

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Expert knowledge for Azure DDoS Protection development including troubleshooting, best practices, decision making, architecture & design patterns, security, configuration, and integrations & coding patterns. Use when enabling DDoS IP/Network Protection, tuning policies, analyzing logs/metrics, or integrating NVAs and Azure Policy, and other Azure DDos Protection related development tasks. Not for Azure Firewall (use azure-firewall), Azure Firewall Manager (use azure-firewall-manager), Azure Web Application Firewall (use azure-web-application-firewall), Azure Virtual Network (use azure-virtual-network).

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Turn in vitro potency and animal pharmacokinetics into a defensible human dose projection — the arithmetic that decides whether a compound can reach its target concentration safely. Use this skill for non-compartmental analysis of a concentration-time profile (AUC, Cmax, terminal half-life, clearance, volume of distribution), one- and two-compartment simulation of a dosing regimen, interspecies allometric scaling, human-equivalent dose conversion by body surface area, and the exposure margin between a projected therapeutic concentration and a toxicology no-effect level. Also trigger on non-compartmental analysis, AUC, clearance, volume of distribution, allometric scaling, human equivalent dose, first-in-human, NOAEL, therapeutic index, or exposure margin.

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Front-door router voor het werken aan een regelrecht-dossier. Gebruik dit aan het begin van een dossier, of bij twijfel over waar te beginnen — het triageert de situatie en routeert naar de juiste skill (regelrecht-stelselanalyse voor desk-review/corpus-completion, regelrecht-audit-products voor live expert-validatie) en de juiste volgorde. Bevat het routeringsprincipe: feitelijke defecten routeren naar de desk, oordeels-/praktijkvragen naar de workshop. Dossier-agnostisch.

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Calculates the lowest effective glucocorticoid dose (dexamethasone or prednisone) to normalize blood pressure and serum potassium in glucocorticoid-remediable aldosteronism (GRA/FH-I) by titrating to biochemical and clinical targets. Indicated when initiating medical treatment for confirmed GRA, triggered by findings such as early-onset hypertension, family history of stroke before age 40, spontaneous hypokalemia, or suppressed plasma renin activity with elevated aldosterone.

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Recommends initiating hydrocortisone replacement at a total starting dose of 8 mg/m2 body surface area per day, given in three or four divided doses, for children with confirmed primary adrenal insufficiency (PAI). Use when starting glucocorticoid therapy in pediatric PAI patients, adjusting the dose according to individual clinical response, growth, and need for stress coverage.

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Determines when to avoid aldosterone suppression testing in hypertensive patients with a positive PA screen who have normokalemia and suppressed aldosterone below assay‑specific cutoffs (<11 ng/dL immunoassay or <8 ng/dL LC‑MS/MS), indicating low likelihood of primary aldosteronism. Use when a clinician asks whether to skip confirmatory suppression testing based on low pretest probability.

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Recommends initiating fludrocortisone 50–100 µg daily for mineralocorticoid replacement in adults with confirmed aldosterone deficiency (e.g., low aldosterone, elevated renin) and no salt restriction. Use when aldosterone deficiency is confirmed in a patient with primary adrenal insufficiency (PAI) presenting with salt craving or postural hypotension.

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Guide pre-endoscopy management decisions for patients on GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide etc.), deciding whether to proceed, delay, or modify the approach based on GI symptoms, fasting status, and indication. Trigger when a clinician asks about GLP-1 RA and endoscopy, semaglutide before colonoscopy, Ozempic before procedure, or whether to hold a GLP-1 agonist before endoscopy.

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Kit de ferramentas abrangente para desenvolvimento com a biblioteca CocoIndex. Use quando os usuários precisarem criar pipelines de transformação de dados (flows), escrever funções personalizadas ou operar flows via CLI ou API. Abrange a construção de workflows ETL para processamento de dados de IA, incluindo incorporação de documentos em bancos de dados vetoriais, construção de grafos de conhecimento, criação de índices de busca ou processamento de fluxos de dados com atualizações incrementais.

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Quando o usuário quer adicionar, corrigir ou otimizar schema markup e dados estruturados no seu site. Use também quando o usuário menciona "schema markup", "dados estruturados", "JSON-LD", "rich snippets", "schema.org", "FAQ schema", "product schema", "review schema" ou "breadcrumb schema". Para problemas de SEO mais amplos, consulte seo-audit.

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