153 skills · sorted by relevance
Query ClinVar for clinical variant significance. Use when user asks about variant pathogenicity, genetic variants, clinical significance, or disease-causing mutations. Triggers on "clinvar", "pathogenic", "variant significance", "clinical significance", "disease variant", "mutation pathogenicity".
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Analyze A/B test results to decide whether to launch a change, extend testing, stop, or investigate further. Check sample size, statistical significance, uncertainty ranges, and effects on other important metrics, then summarize the recommendation and next steps.
Guide for annotating statistical significance (p-value asterisks) on comparison plots. Covers standard notation (ns, *, **, ***, ****), matplotlib bracket+asterisk implementation, and use with seaborn box/violin/bar plots. Use when preparing publication-ready figures with significance markers.
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Diagnoses bias, anomalies, and strange-looking results on a specific PostHog experiment. Covers empty / 0-exposure experiments, sample ratio mismatch, identity fragmentation, multi-variant exposure, uneven-split exclusion bias, significance traps (peeking, A/A, Bayesian vs Frequentist), PostHog-vs-SQL discrepancies, and surprises after mid-run edits. Symptom-driven dispatch to the right diagnostic. TRIGGER when: user asks 'is my experiment biased?' or 'why 0 exposures?', references the bias banner, says a variant looks strange / wrong / off, sees significance flipping, notices PostHog numbers disagreeing with their SQL, sees an A/A test showing significance, or reports surprises after mid-run edits. DO NOT TRIGGER when: creating a new experiment (use creating-experiments), only configuring rollout (use configuring-experiment-rollout) or metrics (use configuring-experiment-analytics), or only asking lifecycle questions (use managing-experiment-lifecycle).
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Track unresolved legal and regulatory gaps by age and significance. Review outstanding issues, close resolved gaps with a resolution note, or record a decision to accept a risk together with its rationale and the person accepting it.
Turn dispute documents into a sourced timeline by extracting dated events and merging duplicates. It highlights significance for the case, records missing source coverage, and supports updated timelines, factual narratives, and timelines focused on a named witness.
Statistical significance calculator for A/B test results with sample size requirements, segment breakdowns, and hypothesis generation. Use when feeding test results, checking statistical significance, calculating sample sizes, analyzing experiment outcomes, or generating next test ideas based on results. Platform: Google and Meta.
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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -split for spliced/BED12/BAM features, and jaccard/fisher as mechanics only. Use when finding overlapping or unique regions between BED/peak/feature files, building consensus peaksets, removing blacklisted regions, transferring annotation values onto intervals, or computing interval-set similarity; route overlap-significance testing to overlap-significance.
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Design, plan, and analyze A/B tests with statistical rigor. Use when the user asks about A/B testing, split testing, experiment design, statistical significance, sample size calculation, test duration, multivariate testing, or conversion experiments. Trigger phrases include "A/B test", "split test", "experiment", "statistical significance", "sample size", "test duration", "which version wins", "conversion experiment", "hypothesis test", "variant testing".
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A/B and multivariate testing methodology. Design experiments, calculate sample sizes, determine statistical significance, avoid common pitfalls, and interpret results. Platform-agnostic framework applicable to landing pages, emails, ads, pricing, and product features. Use when the user asks about A/B testing, split testing, experiment design, statistical significance, or conversion experiments.
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Analyze A/B test results — statistical significance, practical significance, and segmentation. Use when asked to "analyze our A/B test", "is this result significant", or "read these experiment results".
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Design and execute A/B tests for ML models in production using traffic splitting, statistical significance testing, and canary/shadow deployment strategies. Measure performance differences and make data-driven decisions about model rollout. Use when validating a new model version before full rollout, comparing candidate models trained with different algorithms, measuring business metric impact of model changes, or when regulatory requirements mandate gradual rollout.
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Guide for annotating ENCODE regulatory variants with ClinVar clinical significance. Use when users need to check if variants in ENCODE peaks have clinical associations, find pathogenic variants in regulatory regions, or assess variant clinical impact. Trigger on: ClinVar, clinical significance, pathogenic variant, variant classification, clinical variant, disease variant, VUS, benign, likely pathogenic.
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A/B testing specialist v3 — hypothesis, sample size, statistical significance, Bayesian
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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -split for spliced/BED12/BAM features, and jaccard/fisher as mechanics only. Use when finding overlapping or unique regions between BED/peak/feature files, building consensus peaksets, removing blacklisted regions, transferring annotation values onto intervals, or computing interval-set similarity; route overlap-significance testing to overlap-significance.
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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -split for spliced/BED12/BAM features, and jaccard/fisher as mechanics only. Use when finding overlapping or unique regions between BED/peak/feature files, building consensus peaksets, removing blacklisted regions, transferring annotation values onto intervals, or computing interval-set similarity; route overlap-significance testing to overlap-significance.
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Analyze A/B test results for statistical significance with ship, extend, or kill recommendations
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Plan A/B tests to compare page changes using clear hypotheses and meaningful measures. The skill helps define sample size, duration, traffic allocation, and result interpretation, and organize a continuing program of prioritized experiments.
Evaluate scientific manuscripts or excerpts through three independent mock reviewer reports and a combined assessment. Identify strengths, evidence gaps, major concerns, and minor corrections to guide revisions before submission.
Restructure raw article text stored in gbrain into summaries, exact quotes, key insights, and links to related pages. Preserve the original text and connect the article's significance to projects and interests already recorded in gbrain.
Analyze data distributions, trends, unusual values, and differences between groups using suitable statistical methods. The skill guides interpretation of effect sizes, meaning the magnitude of differences, alongside uncertainty and business impact, while checking for misleading conclusions.
Plan A/B tests that compare page variations, from headlines to pricing layouts. Define a hypothesis, choose success metrics, calculate sample size and duration, and prepare launch checks and results reports to support decisions.
Design and evaluate paid-ad experiments with clear hypotheses, comparison groups, sample requirements, and stopping rules. Check data quality before estimating effects, then deliver structured results and a plain-language decision that reflects uncertainty and the population tested.
Update an existing regulatory practice profile through guided, one-at-a-time changes. Adjust watched regulators, significance thresholds, policy references, feeds, or workflows while reviewing how each change affects related tasks and shared company settings.