'spl' 검색 결과

Think and work like an expert Medical Geneticist. Use when a task calls for Medical Geneticist judgment. Reasons from pedigree priors, HPO phenotype match, and ACMG/ClinGen variant classification; integrates exome/genome, CMA, RNA splicing, NBS ACT pathways, Tier 3 carrier screening, SF v3.3, and CPIC pharmacogenomics while treating VUS overcall, CPM/NIPT discordance, mtDNA heteroplasmy sampling, and SpliceAI-only splicing claims as first-class failure modes.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Workflow for event-level and isoform-level splicing analysis with sashimi-ready outputs and splice QC.

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Crossplane for infrastructure as code using Kubernetes CRDs. Use when the user needs to provision and manage cloud resources declaratively through Kubernetes APIs, compose custom infrastructure abstractions, or build internal platforms.

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Exploit-DB and searchsploit reference — EDB→Metasploit module mappings, PoC reliability rubric, CVSS tier quick reference, and searchsploit usage patterns

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Advanced CV for infrastructure inspection including forest fire detection, wildfire precondition assessment, roof inspection, hail damage analysis, thermal imaging, and 3D Gaussian Splatting reconstruction. Expert in multi-modal detection, insurance risk modeling, and reinsurance data pipelines. Activate on "fire detection", "wildfire risk", "roof inspection", "hail damage", "thermal analysis", "Gaussian Splatting", "3DGS", "insurance inspection", "defensible space", "property assessment", "catastrophe modeling", "NDVI", "fuel load". NOT for general drone flight control, SLAM, path planning, or sensor fusion (use drone-cv-expert), GPU shader development (use metal-shader-expert), or generic object detection without inspection context (use clip-aware-embeddings).

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Use before any CLI/TUI display code is written, modified, or audited — runs the 7-stage discipline (Context, Register, Shape brief, Implement, Critique, Audit, Polish) for Typer, Rich, Textual, and Questionary work, grounded in per-project PRODUCT.md and DESIGN.TUI.md/DESIGN.md. Triggers on output formatting, display design, interactive prompts, visual consistency, TUI layout, progress display, dashboard design, design audit, design polish, design critique, shape brief, register decision (brand-cli vs product-cli), and AI-slop checks.

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Split a bound project manual PDF into individual spec section PDFs and extract searchable text. Triggers: 'split specs', 'break up the project manual', 'separate spec sections', 'extract spec text'. Prerequisite for /submittal-log-generator.

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Split a bound drawing set PDF into individual sheet PDFs. Extracts sheet numbers from title blocks via vision, renames files, and records where the cover sheet's drawing index disagrees with the set, logging the ones that need an RFI for rfi-drafter. Triggers: 'split drawings', 'break up the drawing set', 'separate sheets'. Run after /project-setup.

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ISA-101 design rules for Human Machine Interfaces in process automation, covering display hierarchy, color standards, alarm integration, navigation, and situation awareness. Use when designing, building, reviewing, or generating code for HMIs, control system displays, SCADA screens, operator dashboards, or industrial control panels. Use when asked about ISA-101, alarm design, operator display hierarchy, or HMI color standards.

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Exploit validation and exploitation using Metasploit Framework. Runs in a dedicated Docker container (separate from Kali). Validates CVEs discovered by nuclei, nikto, or other scanners with actual exploit modules. Covers exploit selection, payload configuration, exploitation, and post-exploitation pivoting. Uses msfconsole, msfvenom, and the Metasploit module database. Chains from /pentester, /analyze-cve, or /post-exploit when exploitable CVEs are confirmed.

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Use this skill when authoring INVEST-compliant Salesforce user stories from gathered requirements: shaping the As-A/I-Want/So-That stem, writing Given-When-Then acceptance criteria, sizing complexity (S/M/L/XL), splitting stories that are too large for a sprint, and emitting handoff metadata that names the next downstream agent. Trigger keywords: user story, INVEST, story splitting, story sizing, As-A I-Want So-That, story handoff, recommended_agents, backlog item shape. NOT for requirements elicitation or stakeholder interviews (use admin/requirements-gathering-for-sf). NOT for the Given-When-Then technique itself in depth (use admin/acceptance-criteria-given-when-then). NOT for UAT test case design (use admin/uat-test-case-design). NOT for backlog prioritization (use admin/moscow-prioritization-for-sf-backlog).

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Use when setting up, configuring, or troubleshooting Marketing Cloud Journey Builder — including entry sources, activities, decision splits, wait activities, goals, exit criteria, journey versions, test mode, or journey analytics. Triggers: 'journey builder setup', 'entry source configuration', 'decision split not routing', 'exit criteria not removing contacts', 'goal not tracking conversion', 'journey version publishing', 'journey re-entry settings', 'wait activity date field'. NOT for coding a custom activity or entry source — use apex/marketing-cloud-custom-activities. NOT for business units and sender profiles — use admin/marketing-cloud-engagement-setup.

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Set up, configure or troubleshoot Salesforce Collaborative Forecasts: forecast types, forecast categories, rollup methods, quota management, forecast hierarchy, manager adjustments, pipeline inspection integration. Trigger keywords: forecast type, forecast category, cumulative rollup, individual rollup, quota, forecast adjustment, forecast hierarchy, opportunity splits forecasting, pipeline forecast. NOT for configuring the opportunity stages, sales processes or split types themselves — use admin/opportunity-management. NOT for territory-based forecasting setup — use admin/enterprise-territory-management. NOT for Classic/Customizable Forecasting.

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Automate advertising campaigns with AI. Create ads, buy media, manage ad budgets, discover ad inventory, run display ads, video ads, CTV campaigns, and optimize ad performance. Perfect for marketing automation, programmatic advertising, media buying, ad management, campaign optimization, creative management, and performance tracking. Launch Facebook ads, Google ads, display advertising, video marketing, and multi-channel campaigns using natural language. Supports ad targeting, audience segmentation, ROI tracking, and automated bidding.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

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Validate and implement Sinclair ZX80 video emulation in the EMULATORS repository, including CPU-driven display generation, display-file execution, Z80 M1/refresh/HALT/INT interactions, character and inverse-video fetches, line counter and shift register behavior, horizontal and vertical sync, collapsed display files, PAL timing, flicker, and cassette/video coupling. Use when Codex reviews or edits namespace ZX81 code for the /mZX80 model, especially ULA, ULARegisters, MemoryVideoCode, Memory, PortManager, Screen, CPU interrupt timing, raster, or video tests.

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Build automated threat intelligence enrichment pipelines in Splunk Enterprise Security using lookup tables, modular inputs, and the Threat Intelligence Framework.

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Change a Mac's main display resolution in one command: real pixels instead of 4K HiDPI so remote desktop (AnyDesk), screen recording and Screenpipe stop lagging. Use when a remote session is slow or a lower or original resolution is needed: lists modes, picks by width, height, pixel width and refresh rate, self-tests five known traps, verifies after the change and prints a one-line rollback. Triggers: /display-mode, lower the resolution, set 1920x1080, AnyDesk is slow, restore resolution.

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Download and verify the seven platform FFmpeg archives produced for one rust-ffmpeg-splitter commit by GitHub Actions and CircleCI. Use when handing completed splitter CI binaries to rust-ffmpeg-sys without mixing commits or incomplete CI runs.

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TanStack Router bundler plugin for route generation and automatic code splitting. Supports Vite, Webpack, Rspack, and esbuild. Configures autoCodeSplitting, routesDirectory, target framework, and code split groupings.

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This skill should be used when the user asks to "use Metasploit for penetration testing", "exploit vulnerabilities with msfconsole", "create payloads with msfvenom", "perform post-exploitation", "use auxiliary modules for scanning", or "develop custom exploits". It provides comprehensive guidance for leveraging the Metasploit Framework in security assessments.

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Build automated threat intelligence enrichment pipelines in Splunk Enterprise Security using lookup tables, modular inputs, and the Threat Intelligence Framework.

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