'edge' 검색 결과

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.

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Use this skill to evaluate which defensive driving program is best for your fleet. Compares Smith System, CarriersEdge, Compass-native training, and other options.

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Apply practical DAG decomposition, transitive-edge reduction, and reachability indexing to dense dependency graphs. Use when low width and repeated queries justify preprocessing. NOT for cyclic graphs, one-off graph checks, or exact-minimum-chain requirements.

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Defensive counterpart to federated-harbor-redteam: closes the smells that red team opens against The Federated Harbor whitepaper. Federation-specific defenses for cross-harbor primitives — mechanization commitments, scope hedges, cross-paper dependency formalization, pre-emptive analogies (CT, Macaroons, atomic swaps), and defense-in-depth framing (refuses vs prices). Use during a versioned red-vs-white round; pairs with federated-harbor-redteam. NOT for ad-hoc code review, NOT for the Anchor or Bonded papers (use whitehat-defense).

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Create and review Cloudflare Durable Objects. Use when building stateful coordination (chat rooms, multiplayer games, booking systems), implementing RPC methods, SQLite storage, alarms, WebSockets, or reviewing DO code for best practices. Covers Workers integration, wrangler config, and testing with Vitest. Biases towards retrieval from Cloudflare docs over pre-trained knowledge.

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Use when introducing a feature flag system, choosing between release flags / experiment flags / operational flags / kill switches / permission flags, designing percentage rollouts, building kill-switch + circuit-breaker patterns, structuring evaluation contexts (user IDs, plan tier, region), or building flag-cleanup discipline. Triggers: LaunchDarkly / GrowthBook / Unleash / Flagsmith / OpenFeature, percentage ramp, sticky bucketing, kill switch wired to alerting, "we still have flags from 2 years ago", flag debt, OpenFeature provider, evaluation context, default value on provider failure. NOT for A/B test statistical analysis (separate skill), traffic-split routing at the edge, build-time bundler defines, or environment-based config.

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Architects the encryption, codec/transport, and premium-feature layer of a group video-calling product, on top of an already-chosen SFU topology. Covers E2EE patterns (Zoom leader-fan-out, Signal pairwise-fan-out, MLS/TreeKEM as in Discord's DAVE, Telegram's ledger consensus), the SFrame (RFC 9605) + WebRTC Insertable Streams mechanism letting an SFU relay encrypted frames it can't read, codec/transport choice (AV1/VP9 SVC vs. simulcast, Opus, congestion control, Media-over-QUIC, WHIP/WHEP), and which "premium" features (virtual backgrounds, live captions, recording, breakout rooms, spatial audio) survive E2EE vs. structurally can't. Use when adding E2EE to an SFU-based call, choosing a 2026 codec/SVC strategy, or deciding which features to disable under E2EE mode. NOT for call topology/platform choice (see webrtc-adhoc-video-chat, which this composes with). NOT for one-way broadcast (see managed-video-streaming-pipeline). NOT for the DM/group-chat text backend (see realtime-messaging-backend-architecture).

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Apply practical DAG decomposition, transitive-edge reduction, and reachability indexing to dense dependency graphs. Use when low width and repeated queries justify preprocessing. NOT for cyclic graphs, one-off graph checks, or exact-minimum-chain requirements.

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Audit or design server-side indexes, directories, reputations, or aggregates that are DERIVED from traffic a platform witnesses (chain heads, run verdicts, heartbeats, publish activity) so that consent gates the derivation, not merely the read: no shadow index over non-consenting principals, post-consent-only evidence windows, retention bounds and delete-propagation into derived rows, activity-oracle threat modeling, and audit-logged ranking discretion. Use when building a capability directory / whois from witnessed activity, a reputation ledger from settled outcomes, vitals aggregation across tenants, or any "the yellow pages can't lie because they index signatures" feature. Keywords: shadow index, derived index, consent gates derivation, activity oracle, phone book not a log, delist propagation, ranking weight audit, k-anonymous aggregate, subpoena surface. NOT for the consent-screen UX and scope-ladder mechanics themselves (use local-first-tenancy-boundary), reputation scoring math and Sybil economics (use agent-identity-continuity-reputation), or discovery-layer architecture L1/L2/L3 (use agent-discovery-directories-guilds).

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Expert in ALL computational collage composition: photo mosaics, grid layouts, scrapbook/journal styles, magazine editorial, vision boards, mood boards, social media collages, memory walls, abstract/generative arrangements, and art-historical techniques (Hockney joiners, Dadaist photomontage, Surrealist assemblage, Rauschenberg combines). Masters edge-based assembly, Poisson blending, optimal transport color harmonization, and aesthetic optimization. Activate on 'collage', 'photo mosaic', 'grid layout', 'scrapbook', 'vision board', 'mood board', 'photo wall', 'magazine layout', 'Hockney', 'joiner', 'photomontage'. NOT for simple image editing (use native-app-designer), generating new images (use Stability AI), single photo enhancement (use photo-composition-critic), or basic image similarity search (use clip-aware-embeddings).

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Render mathematically-faithful Turkish marbling (Ebru) and paper-marbling with closed-form coordinate-deformation maps — a drop is a radial outward push, a comb/tine is a decaying shear, all composed as homeomorphisms over colored region boundaries. No fluid solver, runs 60fps on a 2D canvas. Use when building a marbling/Ebru toy or generative-art renderer, implementing drop/comb/wave/swirl deformations, scripting traditional patterns (Battal, Gel-Git, Şal, Bülbül Yuvası), keeping combed edges crisp via adaptive resampling, modeling ox-gall shouldering for crisp ring-in-ring drops, or exporting high-DPI marbled prints. NOT for real fluid / Navier-Stokes simulation, metaball / alpha-blended "smoke" blob effects, raster image-processing filters, or non-marbling generative art.

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Epistemic logic for multi-agent perceptual systems — Kripke models, vision sets, public announcement as coordination primitive, and satisfiability-as-reconfiguration applied to agents with limited observability. From Charrier, Ouchet, Schwarzentruber's "Big Brother Logic" demonstration paper (ENS Rennes / IRISA).

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Use when wrangler deploys silently fail or produce wrong artifacts, secrets upload as empty strings, custom domain DNS is not resolving, route assignment broke after rename, observability/tail logs are needed, D1/KV/R2 bindings are missing, OAuth scope errors block a command, cookies on a redirect are not attaching, or the worker exceeds CPU time. Triggers: "Tenant or user not found", "Authentication error" on wrangler d1 push, secret length is 0 after upload, route returns origin not worker, "compatibility_date too old", 1101 errors, custom_domain assignment lost on script rename. NOT for AWS Lambda / Vercel Edge / Deno Deploy (different runtimes), Cloudflare Zero Trust, or R2-specific tuning.

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Designing HTTP cache headers that work correctly across browsers, CDNs, and shared proxies — `Cache-Control` directives per RFC 9111, `stale-while-revalidate` and `stale-if-error` per RFC 5861, the Vary header for varying responses, and surrogate keys for tag-based purging. Grounded in IETF RFCs and Cloudflare/Fastly docs. NOT for service-worker or browser-only caching, Redis/memcached application caching, or edge-function compute.

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Comprehensive Cloudflare platform skill covering Workers, Pages, storage (KV, D1, R2), AI (Workers AI, Vectorize, Agents SDK), feature flags (Flagship), networking (Tunnel, Spectrum), security (WAF, DDoS), and infrastructure-as-code (Terraform, Pulumi). Use for any Cloudflare development task. Biases towards retrieval from Cloudflare docs over pre-trained knowledge.

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Identify and counteract cognitive biases in medical decision-making through systematic error analysis and contextual algorithm application. For diagnostic reasoning, treatment decisions, and clinical judgment improvement. NOT for basic medical knowledge, technical procedures, or non-clinical healthcare domains.

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Systematic methodology for eliciting, representing, and operationalizing expert cognitive skills—pattern recognition, situation assessment, mental simulation—from practitioners without requiring research training. Bridges academic rigor and practical usability.

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Systematic methodology for eliciting, representing, and operationalizing expert cognitive skills—pattern recognition, situation assessment, mental simulation—from practitioners without requiring research training. Bridges academic rigor and practical usability.

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Track the full Toulmin epistemic ancestry of every claim produced by a multi-agent swarm. Each agent output is tagged with an argument chain (claim / data / warrant / relationship) derived from SwarmTracer spans and LineageEdge records, so operators can zoom into any sub-claim and see precisely which agents asserted it, what triggered each assertion, and how contradictions propagated or were synthesised away. The SwarmTracer pattern — wrapping the SwarmAgentExecutor to capture spans, record messages, and build a lineage graph — is the concrete runtime substrate. Argumentative lineage lifts that graph into the Toulmin vocabulary so reasoning provenance is both machine-queryable and human-interpretable.

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Expert bot developer specializing in Discord, Telegram, Slack automation with deep knowledge of rate limiting, state machines, event sourcing, moderation systems, and conversational AI integration. Activate on 'Discord bot', 'Telegram bot', 'Slack bot', 'chat automation', 'moderation system'. NOT for web APIs (use backend-architect), general automation scripts (use python-pro), or frontend chat widgets (use frontend-developer).

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Designs and audits deterministic, authority-filtered partitions of trust-typed context for already admitted bodies or abstract continuation slots. Use when causal context, obligations, disclosure boundaries, vector-space identity, capacity, and omission proofs must survive partitioning. NOT for spawning or admitting agents, choosing worker count, retrieving arbitrary knowledge, writing successor prompts, or granting tools, leases, identity, or effect authority.

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