162건 · 관련도순
Determines whether adrenal venous sampling (AVS) is needed in addition to CT for lateralizing primary aldosteronism before surgery. Trigger phrases include "patient with primary aldosteronism considering surgery", "unilateral adrenal adenoma on CT", "surgical candidate", and "age <35 with hypokalemia and >1‑cm adenoma".
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Recommends performing a dexamethasone suppression test to evaluate for autonomous cortisol secretion in patients with primary aldosteronism and adrenal adenoma. Triggered when a clinician considers whether to perform a dexamethasone suppression test in a patient with PA and adrenal adenoma.
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Use when the user asks to "run the weekly social readout", "which denominator does our engagement rate use", or "which posts won this week and what changes next cycle"; produces the organic-social metric dictionary (every rate names its denominator — ERR engagement-by-reach vs ERI by-impressions vs ER-by-follower — locked across periods), median-not-mean per-post rollups with organic and boosted separated, EMV as labeled exec-translation only (never inside any score), an attributed CHAOSS/Orbit-style community-health readout with employees excluded, and the best/worst-performer write-back the next calendar cycle consumes. Not for dollar-ROI math or the ECHO profile result gate verdict — use roi-calculator and social-quality-auditor. 社媒周报/互动率分母/指标字典/复盘回写
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Edge Computing Specialist IA — Expert en edge computing (Cloudflare Workers, Deno Deploy, Vercel Edge, Bun)
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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.
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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.
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Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.
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Restore image quality using restoration models hosted by fal.ai. The skill covers reducing blur and noise, fixing faces, and restoring old document images, with the full workflow available through the upstream skill bundle.
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Turn written descriptions or Mermaid code into diagrams showing processes, interactions, and data relationships. Choose a color theme and save both SVG files, which stay sharp when enlarged, and high-resolution PNG images.
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Explore public pathogen genome data to verify lineage names, summarize weekly sequence proportions, examine reporting delays, and compare mutation frequencies. Results include filters and denominators, with clear limits on what submitted sequences reveal about infections.
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Process paired-end 16S sequencing reads in QIIME 2 to produce ASVs, distinct sequence variants, and taxonomic assignments. Check input files, primer settings, and read retention while preserving artifacts that record the processing history.
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Analyze flow cytometry data in Python by correcting fluorescence spillover and applying gates that select cell populations. Produce population counts, percentages, and fluorescence summaries, or reproduce supported FlowJo 10 workspace analyses with recorded analysis settings.
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Turns supplied AI agent evaluation results into reports that distinguish autonomous success, human-assisted success, failure, timeout, and invalid runs. Makes metric denominators, retries, timing, costs, and comparison conditions explicit to support evidence-based decisions.
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Prepare raw credit data for pre-loan modeling by checking data quality and screening variables. Review missing values, predictive usefulness, stability, noise, and correlation, then export an Excel report with organization-level statistics and cleaning results.
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Package an existing custom diffusers block into a directory ready for Hub upload. Select a class from a Python file and save its source, configuration, and associated files so others can load the block.
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Instrument Python or TypeScript agents to record runs for Failproof AI, verify local event files, and troubleshoot missing sessions. The skill also guides building evaluator workers that score completed runs on your own infrastructure.
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Amplicon sequence variant (ASV) inference from 16S rRNA or ITS amplicon sequencing using DADA2. Covers quality filtering, error learning, denoising, and chimera removal. Use when processing demultiplexed amplicon FASTQ files to generate an ASV table for downstream analysis.
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Use when the user asks to "audit our social presence" or "is this batch safe to publish"; runs either the typed ECHO asset gate or a separate program-maturity profile, with channel-truth, claim, disclosure, manipulation, UGC-rights, and denominator checks. Not for creator deliverables — use creator-content-auditor; not for launch readiness — use launch-readiness-auditor. 社媒资产门/运营成熟度/发布前放行
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FAIR-aligned exposure quantification: turns a pile of recon findings into a defensible 0-100 + A-F org risk score (Likelihood x Impact, three ownership-aware factors: exposure/threat/impact), an ownership + proof demotion cap so unproven or weakly-owned findings can't inflate the number, a $-denominated FAIR loss-magnitude estimate (IBM/Ponemon per-record cost bands, cross-source record dedup, threat-factor annualization), attack-path amplification (curated red-team chain catalog + generic graph-walk engine, with a kill-chain vs shared-fate honesty gate), and a board-ready one-pager deliverable (hero $ + letter grade + top-3 findings + top attack path + the ask). Extends osint-methodology's severity rubric and client deliverable templates with quantification. Passive analysis only -- operates on findings already collected, no target traffic, no API keys. Use when asked to score risk, quantify exposure, estimate breach cost, build a board report, translate technical findings to dollars, or explain why a grade or dollar figure came out the way it did.
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An overview of the core model API of SeisBench, a Python framework for training and applying machine learning algorithms to seismic data. It is useful for annotating waveforms using pretrained SOTA ML models, for tasks like phase picking, earthquake detection, waveform denoising and depth estimation. For any waveform, you can manipulate it into an obspy stream object and it will work seamlessly with seisbench models.
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Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.
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Load and preprocess imaging mass cytometry (IMC) and MIBI data from raw MCD/TXT through hot-pixel removal, spillover compensation, and variance-stabilizing transformation, covering readimc/steinbock ingestion, NNLS spillover compensation (CATALYST), IMC-Denoise, and the IMC arcsinh-cofactor question. Use when starting analysis from raw MCD files, building per-channel TIFF stacks, compensating channel spillover, choosing an arcsinh cofactor, or preparing single-cell intensities for phenotyping.
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Assembles genomes de novo from noisy long reads (Oxford Nanopore R9/R10/Dorado, PacBio CLR) with Flye (repeat graph), Canu (correct-trim-assemble OLC), NextDenovo, Shasta, Raven, wtdbg2, or miniasm, and reconciles bacterial assemblies into a consensus with Trycycler/Autocycler. Covers matching the input flag to the basecaller era (--nano-hq vs --nano-raw), why a raw long-read assembly is contiguous but low-QV and not finished until polished, haplotig false-duplication and purge_dups, coverage and read-N50 as non-substitutable inputs, and mid-read adapter de-chimerization. Use when assembling a bacterial or eukaryotic genome from ONT or PacBio noisy reads, choosing a long-read assembler, or diagnosing an over-collapsed or duplicated assembly. For PacBio HiFi use hifi-assembly instead.
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Processes eDNA metabarcoding from raw paired-end reads to species tables, navigating ASV (DADA2, UNOISE3) vs OTU (swarm v2) decision (Callahan 2017 vs Schloss multi-copy-16S critique), marker/primer choice (Leray COI, MiFish 12S, 515F/806R 16S, ITS2) with primer-specific bias, OBITools3 v3 command-name break (obi stats plural; .tar.gz taxonomy), tag-jumping with dual-indexing (Schnell 2015; NovaSeq 10x MiSeq), decontam as screening-not-classifier (Davis 2018), read-counts-not-abundance critique (Lamb 2019), site-occupancy modeling (Ficetola 2015), Naive-Bayes calibration limits (Bokulich 2018), and eDNA decay (Strickler 2015). Use when going from raw eDNA FASTQ to species tables, picking marker + denoising pipeline, deciding whether read counts represent abundance, applying occupancy modeling, configuring OBITools3 v3, or interpreting decontam output. Not for clinical 16S microbiome (see microbiome/amplicon-processing).
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