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Assists with building secure JavaScript and TypeScript applications using the Deno runtime. Use when creating servers, CLI tools, or scripts with Deno's built-in tooling, permission model, npm compatibility, and web standards APIs. Trigger words: deno, deno deploy, deno serve, deno kv, deno permissions, secure runtime, jsr.
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You are an expert in Deno Deploy, the globally distributed serverless platform by Deno. You help developers deploy TypeScript/JavaScript applications to 35+ edge locations with zero cold starts, built-in KV storage, BroadcastChannel for real-time, cron scheduling, and npm compatibility — running code within milliseconds of users worldwide without managing infrastructure.
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This skill guides evaluation for malignancy using imaging in patients with a history of adrenal adenoma (post‑adrenalectomy Cushing’s syndrome) when the adenoma demonstrates a CT density of ≥10 Hounsfield units or when pathology is consistent with possible carcinoma. Trigger phrases include “CT density ≥10 HU”, “possible carcinoma on pathology”, and “post‑adrenalectomy CS patient with adrenal adenoma history”.
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Use when working with Deno Deploy Deep — deep Deno Deploy analysis covering project inventory, deployment history, KV database usage, cron job schedules, custom domain mappings, analytics metrics, and environment variable auditing. Use for comprehensive Deno Deploy platform management.
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Measure denoising latency in SGLang diffusion models and identify slow operations with profiler traces. Compare performance and output quality on the same GPUs, check existing optimizations, and gather evidence before starting low-level kernel work.
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通用音频处理：音频剪辑/裁剪、格式转码（mp3/wav/m4a/aac）、音量归一化、从视频提取音轨、多段拼接、淡入淡出、变速（保音高）。当用户说“剪音频”“裁一段”“转成 mp3”“调音量/响度”“提取音轨/扒音频”“拼接音频”“淡入淡出”“加速/减速音频”“变速不变调”时使用。与 audio-denoise 的区别：audio-denoise 专做降噪，audio-editing 做除降噪外的通用音频操作（也内置 denoise 作为兜底）。
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Fix incorrect priority ordering when using denormalized aggregate columns. Use when: (1) Records are processed in wrong order despite ORDER BY on count/sum columns, (2) Top items by some metric aren't being selected first, (3) Aggregate columns show 0 or NULL for records that should have high values, (4) Priority queue processes low-value items before high-value ones. The root cause is often that denormalized columns (vine_count, loop_count, total_orders, etc.) weren't backfilled or maintained properly. Solution: JOIN with source tables to compute actual aggregates at query time.
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Evaluates LP portfolio rebalancing pressure from denominator effects with over-allocation analysis and pace adjustment recommendations. Use when analyzing denominator effects, assessing LP allocation constraints, or modeling portfolio rebalancing.
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Deno runtime guidance — TypeScript-first development, permissions, standard library, and deploying Deno apps.
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This skill suggests follow-up tests for specific comorbidities associated with Cushing's syndrome in patients with adrenal adenoma when CT density is less than 10 Hounsfield units. Use when managing a post-adrenalectomy Cushing's syndrome patient with confirmed adrenal adenoma pathology and low-density imaging (<10 HU).
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Build text, image, and audio features in JavaScript using machine learning models that run in browsers or server runtimes. Covers model selection, execution settings, caching, and memory cleanup without requiring a Python server.
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Build JavaScript or TypeScript applications that run text, image, and audio models in browsers or server runtimes. Guides compatible model selection, GPU or CPU execution, caching, and memory cleanup without requiring a Python server.
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Build and configure web servers with Nitro, including request handlers, caching, storage, and scheduled tasks. The skill also guides deployment to supported runtimes and platforms, plus migration from Nitro v2 to v3.
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音频降噪：去除录音中的背景噪声、电流声、风噪、嗡嗡声，基于 ffmpeg 滤镜链（afftdn/highpass/lowpass）。 当用户说"降噪""去噪""去杂音""消除背景噪声""电流声""风噪""录音有杂音""音频降噪"时使用。 和 audio-editing 的区别：audio-editing 做剪辑/转码/音量等通用音频操作（内置 denoise 兜底），本 SKILL 专做降噪调参。
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Use when the user asks to "run the weekly social readout", "which denominator does our engagement rate use", or "which posts won this week and what changes next cycle"; produces the organic-social metric dictionary (every rate names its denominator — ERR engagement-by-reach vs ERI by-impressions vs ER-by-follower — locked across periods), median-not-mean per-post rollups with organic and boosted separated, EMV as labeled exec-translation only (never inside any score), an attributed CHAOSS/Orbit-style community-health readout with employees excluded, and the best/worst-performer write-back the next calendar cycle consumes. Not for dollar-ROI math or the ECHO profile result gate verdict — use roi-calculator and social-quality-auditor. 社媒周报/互动率分母/指标字典/复盘回写
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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.
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Use this skill when conditioning, loading, preparing, or labeling signal data for analysis or ML training. Covers: cleaning a single signal (fill gaps, remove drift, deoutlier, denoise, resample/align a time base) BEFORE analysis; building a `signalDatastore` pipeline; creating a `labeledSignalSet` for Signal Labeler; deriving labels (filename, folder, in-file, ROI, time-frequency ROI); stratified train/val/test splits; framing long signals; parallel processing; and shaping datastore output for `trainnet`. Triggers include "clean up this signal", "remove drift / detrend", "fill gaps", "remove spikes / outliers", "denoise", "resample to a uniform rate", "align channels", "labels from filenames", "stratified split", "prepare for Signal Labeler", and function names like `fillgaps`, `fillmissing`, `detrend`, `filloutliers`, `smoothdata`, `resample`, `synchronize`, `signalDatastore`, `labeledSignalSet`, `filenames2labels`, `folders2labels`, `splitlabels`, `framesig`, `framelbl`, `createDatastores`.
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Upload video/audio media to BytePlus VOD (Video on Demand) storage, returning the Vid and playback references; supports both local file upload (ApplyUploadInfo + TOS + CommitUploadInfo) and URL pull upload (UploadMediaByUrl); also supports AI-based comprehensive quality restoration on already-uploaded videos (removing compression artifacts, noise, scratches, improving clarity, and configuring Pro-tier color depth). Trigger keywords: upload video, upload media, upload to VOD, URL upload, pull upload, local upload, file upload, UploadMediaByUrl, ApplyUploadInfo, media ingestion, quality restoration, quality enhancement, comprehensive restoration, video denoising, denoise, compression artifact removal, color depth, bit depth, 10-bit, 12-bit, 16-bit.
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Use denoising-diffusion-pytorch for PyTorch DDPM/DDIM image diffusion, 1D sequence diffusion, conditioning and guidance, and advanced diffusion variants.
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Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.
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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.
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This skill recommends transsphenoidal selective adenomectomy (TSS) by an experienced pituitary surgeon as the optimal treatment for Cushing's disease in pediatric and adult patients. Use when a patient with ACTH-dependent Cushing syndrome is a surgical candidate; triggers include overt Cushing's syndrome, elevated UFC or late-night salivary cortisol, and pituitary MRI showing an adenoma.
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Screen a hypercalcemic patient for medication- and supplement-induced causes — thiazides, lithium, vitamin D, vitamin A/retinoids, antiestrogens, theophylline, milk-alkali, SGLT2 inhibitors, immune checkpoint inhibitors, denosumab rebound, teriparatide/abaloparatide, foscarnet, ketogenic diet, aluminium. Trigger when a clinician asks "is this hypercalcemia drug-induced", "thiazide hypercalcemia", "lithium hypercalcemia", "denosumab rebound hypercalcemia", "vitamin D toxicity", "milk-alkali syndrome", "SGLT2 hypercalcemia", or any new hypercalcemia where medication review is needed.
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This skill recommends lifelong biochemical testing for recurrence in all patients with Cushing's syndrome after adrenalectomy, except those with resected adrenal adenoma showing CT density <10 Hounsfield units. Use when determining long‑term follow‑up strategy for a post‑adrenalectomy CS patient; triggers include “post‑adrenalectomy Cushing’s syndrome”, “CT density <10 HU”, and “adrenal adenoma resection”.
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