625건 · 관련도순
Use when stuck on a hard problem, decomposition is unclear, a related problem is needed, or explicit looking-back review will improve transfer. NOT for routine execution with a known procedure, rote checklist work, or domain questions that need specialized subject matter expertise instead of heuristic search.
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Deep analysis of knowledge distillation techniques for compressing large models into smaller efficient ones
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Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution, mRNA:gene ratio, coding density). Covers the assembly-BUSCO-vs-proteome-BUSCO diagnostic, what BUSCO-Duplicated really means, why gene count is a vanity metric, and the QC of transferred annotations. Use when judging whether an annotation is good enough to publish or submit, diagnosing a suspect annotation, or comparing annotation completeness across pipelines.
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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.
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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.
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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.
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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.
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Writes a lightweight Markdown concept handoff from existing decisions and evidence. Use when explicitly asked for a developer handoff, to transfer a prototype or concept to another team, or to prepare a brief for implementation. Not for ordinary prototype completion, building, reviewing or publishing.
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Use when classifying data, setting retention, judging cross-border transfer, or shaping DSR workflow. Triggers on 'how long do we keep this', 'can this data go to the US'.
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Publishes HTML or Markdown as display.dev URLs with public, company, or private access. Supports signup, claiming, sharing, browsing, bounded reads, exact edits, and comment iteration. Use when the user asks to "publish this", "share this", "share with the org", "post this online", "make a private link", "share with [email]", "publish a report", "list my artifacts", "find an artifact", "publish a large file", "publish this generated HTML file", "read this artifact", "search inside this artifact", "change this passage", "make a copy of this artifact", "duplicate version", "create a display.dev account", "claim this publish", "add a company email domain", "transfer an email domain", "change the email domains add-on", "watch comments on this artifact", "respond to comments", or "resolve this comment thread". Use whenever a request contains a display.dev artifact URL (`*.dsp.so/*`). Anonymous publishing returns a 30-day preview and browser claim URL.
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Modify reagents, solutions, reactions, transfers, metabolism, effects, containers, and chemistry UI safely.
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Work with minds, sessions, bodies, roles, antagonists, objectives, ownership, and transfers safely.
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Spawn, initialize, replace, transfer, and delete entities without breaking lifecycle, transforms, containers, or ownership.
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Fornece orientação para treinamento RL de nível empresarial usando miles, um fork pronto para produção do slime. Use ao treinar grandes modelos MoE com FP8/INT4, necessitando alinhamento treino-inferência ou exigindo RL especulativo para máxima taxa de transferência.
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Modelo de fundação para segmentação de imagens com transferência zero-shot. Use quando precisar segmentar qualquer objeto em imagens usando pontos, caixas ou máscaras como prompts, ou gerar automaticamente todas as máscaras de objetos em uma imagem.
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Use this skill when a company needs its record of processing activities for the first time, or has one that is really a list of tools, and asks "build our RoPA", "records of processing", "data map for GDPR", "Article 30 record", "what personal data do we process and why", "data inventory for privacy" or "our DPO needs a processing register". Drafts the record by processing activity from systems, vendors and team interviews, with purposes, data and subject categories, proposed legal bases, recipients, transfers and concrete retention, plus a separate processor record when the company processes data for customers, and a notes file of open questions per owner.
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Use this skill when the company is about to buy, renew or switch on an AI product or an AI feature inside an existing product, and asks "assess this AI vendor", "do they train on our data", "AI supplier questionnaire", "review the AI terms", "can we use this model provider with customer data", "who are the subprocessors behind this AI tool" or "AI vendor risk assessment". Sizes the review to the use, reads the terms, data processing agreement and documentation before asking questions, checks training use, retention, model changes, subprocessors, transfers, security and exit, and writes an assessment with a recommendation plus the follow-up questions for the vendor.
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Use this skill when a risk register has treatment decisions but no plan anyone can execute, or when someone asks "write the risk treatment plan", "turn the risk register into actions", "what do we do about our high risks", "treatment plan for the auditor", "budget the security roadmap from the risks" or "our treatment plan is just a list of controls". Turns each reduce, avoid or transfer decision into dated actions with an owner, budget, dependency and the record that will prove it was done, states the expected residual score and why, and adds interim measures for risks that stay high while the work runs. Writes a CSV plan and a short notes file.
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Use when Kubernetes Server-Side Apply reports field-manager conflicts, controllers overwrite fields, or force-conflicts risks pruning/defaulting side effects; diagnose ownership read-only before choosing relinquish, partition, or explicit transfer.
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Detect lateral movement in network traffic using Zeek (formerly Bro) log analysis. Parses conn.log, smb_mapping.log, smb_files.log, dce_rpc.log, kerberos.log, and ntlm.log to identify SMB file transfers, NTLM account spray activity, remote service execution, and anomalous internal connections.
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Detecting data exfiltration attempts from AWS S3 buckets by analyzing CloudTrail S3 data events, VPC Flow Logs, GuardDuty findings, Amazon Macie alerts, and S3 access patterns to identify unauthorized bulk downloads and cross-account data transfers.
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Business Email Compromise (BEC) is a sophisticated fraud scheme where attackers impersonate executives, vendors, or trusted partners to trick employees into transferring funds, sharing sensitive data,
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Reads one export transaction, order or shipment description and returns a DRAFT export review pack: parties to screen with a screening checklist, an item classification worksheet, a red-flag review, licence-determination questions and open items. Use when the user asks to "prepare the export review for this order", "pre-check this shipment for export control", "who do we need to screen on this deal", "build the classification worksheet for this item" or "assemble the trade-compliance file for this technology transfer". Do not use for vendor security or due-diligence screening of a supplier's questionnaire answers; use vendor-risk-screening-brief instead. Never classifies, screens, clears, decides licence need or releases a shipment; trade compliance does. Drafts for human review; never approves, authorises or signs off.
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