'ml' 검색 결과

Windows アプリ開発 (Windows App SDK / WinRT) のファイル・設定・データ保存リファレンス。 Windows.Storage の StorageFile, StorageFolder, IStorageItem, FileIO, PathIO, CachedFileManager, DataReader, DataWriter, BasicProperties。ApplicationData, ApplicationDataContainer, ApplicationDataCompositeValue のローカル・ローミング設定。 FileOpenPicker, FileSavePicker, FolderPicker, KnownFolders, StorageApplicationPermissions (FutureAccessList / MostRecentlyUsedList)。 JsonObject, JsonArray, XmlDocument, SQLite, EF Core, Microsoft.Data.SqlClient (SQL Server), Cosmos DB, MySQL, MongoDB 接続。

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OpenAI Codex (CLI / IDE / cloud / ChatGPT desktop app) リファレンス。 GPT-6 系, Fast / Ultrafast mode, codex exec, スラッシュコマンド, prompting, AGENTS.md, rules, subagents, approvals, auto-review, sandbox, permission profiles, profiles, config.toml, 環境変数, roles, MCP 設定, GitHub Action, Codex SDK, App Server (JSON-RPC), Agents SDK 連携, Codex skills (.agents/skills), plugins, scheduled tasks, Browser, Computer Use, cloud / local / worktree 環境, git worktrees, Record & Replay, cloud 委譲, GitHub / GitLab / Linear / Slack 連携, administration, provisioning, analytics API, compliance API, LLM gateway, Codex Security 脆弱性スキャン (SARIF), deep scan, triage, findings, threat model, security hardening。

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Hono (軽量・マルチランタイム対応 Web フレームワーク) リファレンス。 Hono App, Context (c.req / c.json / c.text / c.html), HonoRequest, Routing, HTTPException、 Built-in Middleware (JWT, CORS, CSRF, Cache, Logger, Compress, Basic / Bearer Auth, Mount)、 Helpers (Cookie, Streaming, WebSocket, Factory, RPC)、 Cloudflare Workers / Deno / Bun / Node.js / AWS Lambda 対応、@hono/* アダプターパッケージ。

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Rust 製 AI/ML ライブラリ fandhe-ai のリファレンス。Burn / candle / tch 非依存の from-scratch 実装。 tape(), tape_for, Tape, Gradients, Tensor, Var, LinearVars, autodiff, kernel fusion, FusionPlan, BackendOps, Device (Cpu / Cuda / Metal), DeviceParamStore, compat::array, compat::Sequential, nn::Module, optim (AdamW / GradScaler), data::DataLoader, ONNX import / export, safetensors, inference::generate / KvCache, guardrail / self-repair CLI。

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Better Auth (TypeScript 認証フレームワーク) v1.7 リファレンス。 認証・認可、サインアップ・サインイン、セッション管理、OAuth、パスキー、二要素認証 (2FA / TOTP)、SSO / SAML、SCIM、 OAuth Provider (OAuth 2.1 / OIDC)、MCP 認可 (@better-auth/mcp)、Infrastructure (dash / sentinel)、 プラグイン (organization, admin, magic-link, anonymous 等)。betterAuth, createAuthClient, signUp, signIn, getSession。 Next.js, Nuxt, SvelteKit, Hono, Express, Expo, TanStack, Effect 統合。

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Wear OS (Kotlin) の androidx.wear API・Watch Face Format (WFF) リファレンス。 Wear Compose の CurvedLayout, rotary input, ambient mode, one-handed gestures, ScalingLazyColumn。 Tiles / Material3TileService / ProtoLayout, ComplicationDataSourceService と ComplicationData 型, Health Services (MeasureClient, ExerciseClient, PassiveMonitoringClient), Data Layer (ChannelClient), WFF の XML 要素・式・コンプリケーションスロット・ユーザー設定・Watch Face Designer。

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Biome (Rust 製フォーマッター・リンター) リファレンス。 JavaScript / TypeScript / JSX / CSS / JSON / GraphQL / HTML (Vue, Svelte, Astro) 対応。 biome.json, biome check / lint / format / ci / migrate / upgrade, linter ルール・preset・domains, GritQL プラグイン, assist (organizeImports), suppressions (biome-ignore), LSP / VS Code / Zed, ESLint / Prettier 移行, monorepo, CI。

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Interact with UI Toolkit (UXML/USS) runtime UI in PlayMode. Use INSTEAD OF uloop-simulate-mouse-ui / uloop-simulate-mouse-input whenever the target UI is UI Toolkit — those tools only reach uGUI and report 'no UI element hit' or silently do nothing on UI Toolkit panels.

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Unity 6 UI development guide. Use when building user interfaces, menus, HUD, buttons, or any UI elements. Covers UI Toolkit (recommended for new projects — USS, UXML, UI Builder, data binding), uGUI/Canvas (legacy runtime UI), and IMGUI. Based on Unity 6.3 LTS documentation.

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Generate Skills from HTTP MCP servers with async job patterns (submit/status/result). Use when converting MCP specifications (.mcp.json) into reusable Skills using mcp_tool_catalog.yaml. Supports --lazy mode for context-saving generation. Also use for calling async MCP tools via JSON-RPC 2.0 with session-based polling.

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Builds an interactive HTML dashboard visualizing the Agent Skills ecosystem by fetching live data from github.com/agentskills/agentskills. Use this skill whenever the user wants to explore, research, or visualize Skills architecture, the SKILL.md spec, ecosystem adoption, repo stats, or any Skills intelligence dashboard. Trigger when the user mentions "skills dashboard", "skills ecosystem", "skills architecture overview", "agentskills repo", or wants to analyze how different tools implement Agent Skills. Optimized for Perplexity Computer — Computer fetches all data live, no static files required.

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This skill should be used when working with Python projects that use uv for package and project management. Use this skill for running Python scripts and CLI tools with `uv run`, managing dependencies, creating projects, handling virtual environments, and executing commands within isolated project environments. Essential for projects with pyproject.toml files.

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Use when the user is explicitly working with Quarto, .qmd files, _quarto.yml, Quarto projects, or Quarto features such as callouts, cross-references, citations, Mermaid diagrams, extensions, websites, books, presentations, and reports. Also use for explicit migration from or comparison with R Markdown, bookdown, blogdown, xaringan, distill, or Jupyter notebooks to Quarto. Do not use for general R Markdown or related-format questions unless Quarto or migration to Quarto is explicitly mentioned.

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

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Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces. Covers FCS 2.0/3.0/3.1/3.2 internals ($PnE linear-vs-log, $DATATYPE, $SPILLOVER vs SPILL vs $COMP, $TIMESTEP), channel/parameter metadata, the silent linearize/truncate defaults, and R (flowCore, flowWorkspace, CytoML) plus Python (FlowKit, readfcs) readers. Use when loading flow or mass cytometry data, mapping detector channels to antibodies, extracting the event matrix, choosing a reader, or bridging FCS to the scanpy/AnnData ecosystem before preprocessing.

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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Defines cell populations in flow and spectral cytometry through manual gates (rectangle, polygon, quadrant, boolean) and reproducible automated gating (openCyto gating templates, flowDensity data-driven thresholds, flowClust model-based gates), organized as a hierarchical GatingSet (flowWorkspace) and round-tripped with FlowJo via CytoML. Covers the canonical gate order (time -> debris -> singlets -> live -> lineage), FMO-vs-isotype boundary setting, gate-order dependence and recompute semantics, rare-event/MRD gating, and per-population statistics. Use when building a gating strategy, automating a manual FlowJo scheme across samples, choosing manual vs data-driven gates, or extracting population frequencies.

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Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; Duchêne 2015), recombination masking via Gubbins and ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction (Volz & Frost 2014; preferential-sampling extensions), MASCOT structured coalescent for migration, BICEPS-vs-BSP skyline choice, multi-chain BEAST2 convergence diagnostics, and reconciliation between phylodynamic R_e and case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline (Stadler 2013) models, diagnosing temporal-signal failure, masking recombination before clock inference for *Streptococcus pneumoniae* / *Neisseria gonorrhoeae* / *Klebsiella* / *E. coli* phylodynamics, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

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Retrieve records from NCBI databases using Biopython Bio.Entrez (EFetch, ESummary). Use when downloading sequences, fetching GenBank/GenPept records, getting document summaries, parsing nested XML, navigating GI deprecation, choosing between rettype+retmode combinations, and parsing into Biopython SeqRecord/SwissProt objects. Covers nucleotide, protein, gene, pubmed, sra, gds, taxonomy, snp, clinvar.

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Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.

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Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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