707건 · 관련도순
Improve the code that plans, reviews, and controls agent work while keeping the model fixed. Darwin Mode tests changes in isolated environments and retains variants that pass tests and show measurable improvement.
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Write Google Ads headlines, descriptions, and responsive search ad components. Create alternative messages for A/B testing, which compares ad versions, and develop copy ideas aimed at improving the click-through rate of existing ads.
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Understand how unfamiliar code works from a security perspective. The skill maps architecture, follows untrusted input through the code, and searches for similar vulnerability patterns, with file and line references to support static analysis and finding validation.
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Property-based testing with Hypothesis for discovering edge cases and validating invariants. Use when implementing comprehensive test coverage, testing complex logic with many inputs, or validating mathematical properties and invariants across input domains. Triggered by: hypothesis, property-based testing, @given, strategies, generative testing.
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Score, annotate, and analyze the functional impact of genetic variants using AlphaGenome Variant Impact (AVI) scores. Query variants in chr:pos:ref>alt format, annotate VCF/tabular callsets, perform saturation mutagenesis window scans (1-based closed chr:start-end), and extract GENCODE v46 GTF gene/exon/junction coordinates all via the AlphaGenome Atlas API.
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Polish assemblies and call variants from Oxford Nanopore data using medaka. Uses neural networks trained on specific basecaller versions. Use when improving ONT-only assemblies or calling variants from Nanopore data without short-read polishing.
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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.
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Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex rearrangements from ONT or PacBio data, especially those missed by short-read methods.
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Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.
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Use when the user asks to "write the email", "draft subject lines", or "build email creative"; produces the pre-click unit — subject-line variants + preheader, body copy, one clear CTA, and a plain-text alt — message-matched to the destination page and claims-ledger-aware. Not for pre-scoring or ranking subject-line variants (spam/truncation/render pre-score) — use subject-line-lab; not for scoring the email or computing EQS — use email-quality-auditor; not for the multi-step flow — use email-sequence-designer; not for the A/B test plan — use send-experiment-designer. 邮件文案/主题行/邮件创意
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End-to-end composite that turns a single brief into voice-tuned X post variants, LinkedIn post variants, and a matching social graphic. Orchestrates create-x-content + create-linkedin-content + goose-graphics in one invocation. Asks about graphic format when not specified, with heuristic-driven recommendations.
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Draft voice-tuned X (Twitter) post variants from a free-form brief. Reads a personal voice guide (generated via generate-voice-guide), produces 2–5 variants with distinct framings (simple-howto, problem-first, hype, mechanism-breakdown, etc.), and self-checks against the voice guide's banned phrases before returning.
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Draft voice-tuned LinkedIn post variants from a free-form brief. Reads a personal voice guide (generated via generate-voice-guide), produces 2–5 variants with distinct framings, applies LinkedIn-specific defaults (arrow bullets, "why this matters" beat, 150–500 words), and self-checks against the voice guide's banned phrases before returning.
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Phases small variants, SVs, and methylation from Oxford Nanopore and PacBio long reads (read-backed/physical phasing) with WhatsHap, LongPhase, or HiPhase, and haplotags the BAM (HP/PS tags) for allele-resolved downstream analysis. Covers why phase blocks break at het-sparse gaps (read length x heterozygosity), why phasing the VCF is useless until the BAM is haplotagged, the GT-pipe/PS and read HP/PS tag spec, reporting block N50 with switch error, the diploid-assumption/CNV/haploid-region traps, trio phasing as the gold standard, and the boundary to statistical panel phasing. Use when phasing long-read variants, haplotagging reads for allele-specific methylation/expression or phased SVs, choosing WhatsHap vs LongPhase vs HiPhase, trio phasing, or assessing phasing quality.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.
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Read-only drift detector. Diffs SPEC.md against current code and reports violations grouped by severity. Writes nothing — suggests remedies via the spec or build skills but never invokes them. Triggers when the user asks to check drift, audit the spec, verify invariants, or ask whether code still matches the spec. Phrasings: "check drift", "audit the spec", "does the code still match §V", "check invariants", "spec vs code".
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Use this skill when converting Markdown to Word DOCX or DOCX back to Markdown with Pandoc, especially when the output should use the bundled Chinese Word reference templates, heading numbering variants, list indentation variants, SCI paper templates, and Lua filters for HTML tags, image captions, font color, and inline code styles.
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Use when making multiple independent ad or campaign edits from existing footage with Scenario: hook, CTA, copy, end-card, placement, or targeted visual variants. Also for revising one variant or resuming a partially completed batch. Not for a new commercial from a still image, ordinary single-clip grading, or automatic Cartesian combinations.
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Use when a Unity 6.3 URP task involves shaders: hand-written HLSL, Shader Graph water, toon, dissolve or outline, Custom Function nodes, a renderer feature or full-screen effect on Render Graph, compute shaders, shader variants, keywords, stripping, Shader Build Settings, PSO warm-up, or shader cost; or when a material turns pink or invisible, casts no shadow, ignores extra lights under Forward+, an effect 'does nothing', the game stutters the first time something appears, or builds bloat with variants.
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Use when investigating common or slow variants, repeated work, unusual paths, or a specific Process Mining case.
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Cross-format content adaptation. Turning one substantial piece into many derivative formats (blog series, email sequences, social posts, webinars, podcasts, video shorts) without losing the original's value or producing AI-slop variants. The discipline of adaptation per medium rather than mass-blast distribution. Triggers on content repurposing, content adaptation, cross-format content, content atomization, content multiplication, content distribution across formats, source-piece-to-derivative, video shorts from blog, email from whitepaper, podcast from article, blog series from research. Also triggers when a flagship piece is shipping but the team has not planned how to extend it across formats, when repurposing is happening but the derivatives feel mass-produced, or when AI-assisted repurposing is producing slop variants of strong source pieces.
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Generate A/B test variants for affiliate content. Triggers on: "create A/B test", "test my headline", "optimize my CTA", "generate variants", "split test ideas", "improve click-through rate", "test my landing page copy", "headline alternatives", "CTA variations", "which version is better", "optimize conversions", "test my email subject line", "compare approaches".
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Generate formal specifications including preconditions, postconditions, invariants, and contracts from code or requirements. Use this skill when documenting APIs, creating formal verification annotations, defining function contracts, specifying class invariants, writing design-by-contract code, or preparing code for formal verification. Supports multiple specification languages including JML, ACSL, Dafny, Eiffel contracts, and documentation annotations.
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