'did' 검색 결과

Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CTCF-only/DNase-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Disposable spike in an isolated worktree. Not a merge candidate.

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Re-explain the last deliverable in Task Card vocabulary when it did not land.

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Azure Identity SDK for Rust authentication. Use for DeveloperToolsCredential, ManagedIdentityCredential, ClientSecretCredential, and token-based authentication.

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Advogado criminalista especializado em Maria da Penha, violencia domestica, feminicidio, direito penal brasileiro, medidas protetivas, inquerito policial e acao penal.

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Audit whether a thesis's stated conviction matches its evidence, and whether any Conviction Trigger has silently fired without being actioned. Use when user says "conviction audit", "is my conviction right on [TICKER]", "did a trigger fire", or "should I re-rate [TICKER]".

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Generate a backward-looking retrospective of vault activity (addressed callouts + Log entries) over a time window (1w / 1m / 1q), overlay with newsflow + earnings transcripts + price action, and rank trade ideas by the gap between official narrative and market reaction. Output is an immutable Research note. Use when user says "retro", "retrospective", "what did I do this week/month/quarter", "review activity against market", or "recommend trades from recent research".

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Weekly sweep of ALL transcript-bearing spoken events (earnings calls, conference firesides, CMDs, investor days, AGMs, investor updates) for every active thesis, via the Quartr watchlist. Produces a triage digest in Daily Intel/ flagging thesis-touching mentions and recommending deep reads. Use when user says "event sweep", "what did my companies say this week", "conference sweep", or on the weekly schedule. Also `--setup` (build/rebuild the Quartr watchlist from active theses) and `[N]` (window override in days, default 8).

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Verify a released archon binary works end-to-end via a specific install path. Use when: cutting a new release, reproducing a user bug report on the released version, or validating that a hotfix binary actually works after a re-tag. Triggers: "test the release", "test 0.3.1 via brew", "verify the curl install", "smoke test the binary", "did the release binary work", "run /test-release", "verify the release". NOT for: testing dev work (use bun link directly), testing unreleased changes (build locally via scripts/build-binaries.sh first), or running the full validate suite (bun run validate is separate).

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Responde dimensão, proporção, área segura, tipografia mínima e contagem de slides por plataforma. Use quando o usuário perguntar "qual o tamanho", "que dimensão", "quantos slides", "área segura", "cabe texto onde", "especificação do formato", ou quando outra skill precisar validar medidas. Fonte única desses números.

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Review or refactor an existing SKILL.md and its bundled resources — a smaller always-loaded core, conditional references, preserved behavior, lean/guided consumer profiles, and an A/B protocol to compare a candidate with the previous version. Use when a skill repeats itself, loads references on every run, triggers too broadly or misses legitimate requests, or needs its efficiency measured across models. Do NOT use for writing a new skill from scratch, refactoring application code, translating a skill verbatim, or performing the target skill's own task.

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Manage project learnings. Review, search, prune, and export what gstack has learned across sessions. Use when asked to "what have we learned", "show learnings", "prune stale learnings", or "export learnings". Proactively suggest when the user asks about past patterns or wonders "didn't we fix this before?"

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Weekly engineering retrospective. Analyzes commit history, work patterns, and code quality metrics with persistent history and trend tracking. Team-aware: breaks down per-person contributions with praise and growth areas. Use when asked to "weekly retro", "what did we ship", or "engineering retrospective". Proactively suggest at the end of a work week or sprint. (gstack)

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Generates a polished, leadership-ready performance briefing with KPI tiles, executive narrative bullets, and a driver analysis — all as a print-ready HTML document. Always use this skill when someone asks for an executive summary, performance briefing, leadership readout, stakeholder update, or business review — even if they don't say "executive" explicitly. Trigger phrases include: "write a summary of last week's performance," "create a briefing for our leadership team," "produce a monthly business review," "what should I tell executives about our metrics," "generate a performance narrative," "QBR summary," "weekly business review," "board update," "stakeholder briefing," "how did we do last week," or "give me a performance snapshot." When in doubt, use this skill — it is always better to produce a polished briefing than a raw data dump.

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Produces a compact KPI digest showing how key metrics changed over a period and what's driving the movement. Use this skill when someone asks for a performance summary, a weekly recap, a morning briefing, a KPI update, or any variation of "how did we do this week/month." Also trigger for "give me a performance overview," "what moved in the last 7 days," "pull our AA KPI report," or "summarize our metrics."

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Produces a compact KPI digest showing how key metrics changed over a period and what's driving the movement. Use this skill when someone asks for a performance summary, a weekly recap, a morning briefing, a KPI update, or any variation of "how did we do this week/month." Also trigger for requests like "give me a performance overview," "what moved in the last 7 days," "pull our KPI report," or "summarize our metrics."

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Summarize authored commits over a user-specified time period into a concise update

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Route natural-language cleanup, refactor, migration, and candidate ranking goals through ATM before local analysis.

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Record durable project decisions with rationale, alternatives, assumptions, status, and revisit triggers. Load when the user says record this decision, we decided, decision log, why did we choose, revisit this later, or capture architectural/process rationale.

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