「eth」の検索結果

Foundational ethics, authority hierarchy, and structural principles for the Predicate agent. Always-on law (composable system-prompt core): Truth>Harmony, Evidence>Authority, Halt>Assumption, Outcomes>Process — four ordered principles that govern every walk. Reference (by-moment): conflict resolution, ethics adjudication, novel situations, precedence walkthrough, entropy diagnostics, principled resistance. Trigger (reference depth): resolving rule conflicts, ethics calls, novel situations. Prompt contains: constitution, principles, precedence, truth over harmony, outcomes over process, evidence over authority, principled resistance.

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First-principles strategy — strip away conventional assumptions and find the theoretical maximum for your business. Three modes. Diagnostic mode runs a full session (45+ min) to define your theoretical maximum, map the gap honestly, classify constraints, invert for failure modes, set strategic intent, and work backwards to your first intervention. Review mode (15-20 min) checks whether your theoretical maximum has shifted, whether the gap has changed, and whether you're still climbing the right peak. Alert mode defines constraint-shift, peak-shift, and local-peak triggers that tell you when to reassess. Use when someone is stuck optimising incrementally, when conventional wisdom is driving strategy, when a new technology or regulation changes what's physically possible, or when you suspect the business is climbing a local peak. Integrates with company-context.md. Based on practice by Eterdis (eterdis.com).

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Perform static and symbolic analysis of Solidity smart contracts using Slither and Mythril to detect reentrancy, integer overflow, access control, and other vulnerability classes before deployment to Ethereum mainnet.

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匠Methodの成果物から企画書を生成（フォーマット選択可能）

匠Methodの成果物からRDRAの初期要望を生成

匠Methodのゴール記述モデルを作成

Answer whether a specific advisory reaches anything in THIS repository — which manifest declares the package, at what version, whether the version is in range, and whether the vulnerable code is reachable. Use when someone asks "does CVE-… affect us", when triaging an advisory against a real codebase, or before spending effort on a fix.

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Two-phase code quality skill: (1) review codebase for structural smells — file LOC, method LOC, accidental complexity, test readability — producing a structured report, then (2) fix all smells via provable refactorings with ACN micro commits and green-bar-at-all-times discipline. Use this skill when the user says 'sweep', 'code review', 'find code smells', 'check method lengths', 'review for complexity', 'tidy up the codebase', 'refactor smells', or asks about long methods, test readability, or accidental complexity. Also trigger when users ask to 'clean up' or 'improve code quality' across multiple files.

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Knowledge base from the Expanded Guidance for NASA Systems Engineering (NASA/SP-2016-6105-SUPPL, Volume 1, March 2016) — the practitioner-depth supplement to the NASA SE Handbook. Use for the load-bearing mechanics the handbook compresses: the SE Engine's per-phase cadence and the iterative-vs-recursive distinction, the AS9100 crosswalk, life-cycle tailoring vs. customization and the Compliance Matrix, the recursive system-design consistency loop (ConOps vs. Operations Concept, requirement flow/type/ownership, successive refinement), product realization (verify/qualify/accept/certify cardinality, protoflight, 'test the way we fly' coverage, two-form transition), and the crosscutting technical-management procedures (six-step scheduling, cost-estimating method selection, JCL, interface document family, RIDM/CRM, CM baselines, EVM arithmetic, MOE/MOP/KPP/TPM, the three required leading indicators, and the decision-analysis method catalog). This is the DEPTH layer — it deliberately does NOT restate the base definitions; pair it with the nasa-se-handbook pack. Scope: NASA space-flight SE practice (Vol 1 Practices); thin on the Vol 2 process-appendix detail, on non-NASA/commercial life cycles, and on software-engineering methodology.

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Knowledge base from the NASA Cost Estimating Handbook (CEH) v4.0. Use for NASA's 12-step, three-part cost estimating process (Project Definition, Cost Methodology, Cost Estimate); the WBS, CADRe, and ONCE data backbone; estimating methodologies (analogy, parametric/CER, engineering build-up, EVM, Delphi); ground rules and assumptions, data normalization and inflation (BY/CY/RY); the point-estimate-to-S-curve cost-risk chain and Unallocated Future Expense (UFE) reserves; Joint Cost and Schedule Confidence Level (JCL) analysis via probabilistic cost-loaded schedules; decision-support analyses (sensitivity, trade studies, make/lease-vs-buy, affordability, CAIV); and economic analysis (discounting, NPV, OMB Circular A-94). The cost-estimating complement to NASA's SE and risk packs. Does NOT reproduce the handbook's tool-specific procedures, worked examples, or appendix-depth methods (it names the appendices), nor cover full DoD/GAO cost guides, schedule construction, or formal risk management beyond the cost interface.

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インフラストラクチャとアプリケーションの包括的なメトリクス収集、ストレージ、モニタリングのためのPrometheusをセットアップします。メトリクス収集の実装、モニタリングインフラストラクチャのセットアップ、アラートシステムの設定時に使用します。

Perform static and symbolic analysis of Solidity smart contracts using Slither and Mythril to tespit etme
reentrancy, integer overflow, access control, and other vulnerability classes before Dağıt:ment to Ethereum mainnet.

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Perform static and symbolic analysis of Solidity smart contracts using Slither and Mythril to detect reentrancy, integer overflow, access control, and other vulnerability classes before deployment to Ethereum mainnet.

日本語の概要は準備中です。原文の説明を表示しています。

Discover conserved quantities and symmetries from trajectory data. Identifies energy, momentum, angular momentum, and custom invariants using neural networks and symbolic methods. Inspired by Noether's theorem.

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Design AI ethics frameworks with principles, review processes, and governance. TRIGGERS - Use when user needs help with ai-ethics-framework related tasks.

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Establish AI ethics committees. TRIGGERS - Use when user needs help with ai-ethics-committee related tasks.

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Check the terms of a specific side-work assignment offered as gyomu-itaku or freelance work in Japan, item by item: what the client has actually put in writing about the deliverable, the fee, the payment due date, what counts as out of scope, how many revisions are included, who bears expenses, who owns the result, confidentiality, and how either side can end it. Convert the fee into an effective hourly figure over the hours the work will really take including meetings, revisions and unpaid preparation, and count the days from delivery to the payment due date. Use when someone is offered or is discussing a paid side job, a freelance assignment, spot consulting, or paid trial work and wants to know what is still unwritten before starting; do not use to judge whether the fee is fair or the terms lawful, to decide whether to accept, to draft or sign the contract for the user, or to check whether their employer's rules permit side work, which is sidework-rules-check.

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Turn vague preferences about employers into criteria that can actually be used to choose between them: for each one, what would have to be seen to confirm it, whether it comes from firsthand experience or from an untested assumption, whether it is a must, a nice-to-have, or something to avoid, and which pairs of criteria pull against each other while both being treated as required, then test the set against real candidates. Use when a new graduate is working out what to select employers on, when someone who has decided to move needs criteria for where to apply, or when a stated axis like "a place I can grow" needs to be made checkable; do not use to recommend an industry, job, or employer, to score or rank candidates, or to judge someone's stated preferences.

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Work out the order and the loose ends before turning down an offer or withdrawing from a selection process: whether the offer being kept is actually settled in writing, whether each decline is mid-selection, post-offer, or after acceptance, who besides the employer has to be told when the application came through an agent, a school recommendation, or a referral, which reply deadlines have passed, and what documents, expenses, or borrowed items are still outstanding. Use when a user holds more than one offer and needs to decline the rest, wants to withdraw from a process they are no longer pursuing, or has been asked to turn down other employers as a condition; do not use to decide whether to decline, to rule on what declining after acceptance means legally, or to send any message.

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Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.

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YC Office Hours — two modes. Startup mode: six forcing questions that expose demand reality, status quo, desperate specificity, narrowest wedge, observation, and future-fit. Builder mode: design thinking brainstorming for side projects, hackathons, learning, and open source. Saves a design doc. Use when asked to "brainstorm this", "I have an idea", "help me think through this", "office hours", or "is this worth building". Proactively invoke this skill (do NOT answer directly) when the user describes a new product idea, asks whether something is worth building, wants to think through design decisions for something that doesn't exist yet, or is exploring a concept before any code is written. Use before /plan-ceo-review or /plan-eng-review. (gstack)

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