「nest」の検索結果

Convert a meeting into async work that actually decides — the doc-plus-deadline format that replaces the room, the comment-window rules, the decision-closure step that async usually fumbles, and the honest test for what still needs synchronous. Use when asked can this meeting be async, replace our status meeting with a doc, run this decision without a call, or async isn't working for us. Produces the conversion design, the async artifact format, the closure protocol, and the still-needs-a-room list.

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Think clearly about whether bankruptcy is the right move, or whether another path fits better — without shame and without a sales pitch. Use when asked should I file for bankruptcy, is bankruptcy my best option, alternatives to bankruptcy, or what happens if I file. Produces an honest read on whether your situation is the kind bankruptcy actually helps, the main types and what each does (and doesn't) discharge, the real trade-offs (what you keep, the credit impact and its recovery, what's not dischargeable), the alternatives to weigh first (negotiation, debt management, doing nothing on time-barred debt), and a strong push to consult a bankruptcy attorney. Not legal advice.

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Draft the hard personal message you keep putting off — chasing money a friend owes, backing out of plans, checking in after a fight, following up on an unanswered text. Use when asked to help send an awkward text, how to say something uncomfortable to a friend, word a difficult personal message, or bring up something touchy. Produces a couple of calibrated options, the one line to open with, and the send/wait/call judgement call — warm, honest, and not a doormat.

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Extract every hidden assumption from a plan or document and put a price on each one — what it costs if wrong, what it costs to test. Use when about to commit to anything whose author says 'obviously' or whose spreadsheet has hardcoded cells: the bounty hunt makes the invisible load-bearing beliefs explicit and tells you which three to test this week. Produces the assumption ledger (priced and ranked), the cheapest test for each dangerous one, and the document's honest confidence statement.

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Present a design to a client so they can make a decision rather than react to a picture — the brief restated, the moves explained against it, the options with their trade-offs, and a specific decision requested. Use when asked to present a design to a client, prepare a design review meeting, present concept options, or when a client keeps changing their mind after sign-off. Produces the presentation structure, the brief-to-design traceability, the options with honest trade-offs, the cost and programme position, and the decision record that makes sign-off stick.

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Get your attention back with a 30-day protocol that assumes you'll break it — a screen-time ledger without moralizing, friction engineering (what to delete, grayscale, where the phone sleeps), planned relapses, and honest replacement activities for the boredom that shows up on day 3. Use when someone says 'my screen time is 7 hours', 'I want a dumbphone', 'digital detox', 'I can't read books anymore', or 'my attention span is gone'. Produces the ledger, a personal friction plan, and the 30-day protocol with expected failure points.

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Audit whether the organisation's AI spend actually paid — measured against baselines, not vendor math or vibes. Use when a CFO asks what the AI tools returned, when renewing AI contracts, when consolidating overlapping AI subscriptions, or to build the measurement plan before the next spend. Produces an ROI audit with per-tool verdicts (keep/consolidate/cut), the honest-measurement method behind each number, and a baseline plan for whatever can't be scored yet. To forecast ROI before an investment use roi-estimator; this skill measures what already happened.

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Assess whether and how someone can safely stay in their own home as they age — the home hazards, the support gaps, and the modifications and services that make it work. Use when asked can my parent stay in their home safely, aging in place assessment, is it safe for them to live alone, or what do we need for them to stay home. Produces a room-by-room safety read (fall hazards, accessibility), an honest look at the daily-living and support gaps, the modifications and services that could close them, warning signs that home may no longer be safe, and how to raise it respectfully — helping a family make a clear-eyed, dignity-preserving decision. Not medical advice.

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GSAP animation reference for HyperFrames. Covers gsap.to(), from(), fromTo(), easing, stagger, defaults, timelines (gsap.timeline(), position parameter, labels, nesting, playback), and performance (transforms, will-change, quickTo). Use when writing GSAP animations in HyperFrames compositions.

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Find and remove AI slop — the generic, machine-default visual and copy tics of vibe-coded products — from a web project. Use when the user asks to "kill AI slop", "de-slop", "remove the AI look", "make this not look AI-generated", or clean up a landing page / UI / docs that feels templated. Detects and fixes the catalogue of tells: indigo→violet gradients, gradient-clip headlines, the default semantic palette, one-hue status boxes, atmospheric gradients, serif-italic emphasis, highlighted keywords, AI copywriting voice ("not just X — it's Y"), emoji everywhere, glowing status dots, wobbling spinners, colored-left-border callouts, pastel icon tiles, glassmorphism, over-rounding, oversized shadows, borders that die at corners, badge & pill spam, AI-drawn SVG icons, kickers over every heading, flat type hierarchies, invented stat rows, 01/02/03 section markers, cards nested in cards, the default Inter/Space Grotesk look, and more. Works on HTML/CSS, React/Vue/Svelte/Astro, Tailwind, PHP, and Markdown copy.

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Honest marketing-site method: audience, offer, proof, objections, privacy, art direction, handoff. Triggers: marketing site, landing page, company website, portfolio, campaign page, conversion, positioning, value proposition, CTA, social proof, privacy policy.

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Use when executing and reporting the analysis/interpretation for an American Anthropologist (AA) manuscript so it survives expert anonymous review — disciplined ethnographic/qualitative inference, honest interpretation, and (for biological/archaeological work) sound quantitative analysis. Guides analysis and interpretation norms; it does not fabricate evidence or quotations.

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Use when articulating why an Agricultural Systems (AgSy) result matters — its relevance for farm design, management, decision support, or policy. AgSy values systems analysis that informs a decision, so this is what separates an AgSy paper from a methods demo. It frames implications honestly within the model's scope; it does not over-claim or invent impact.

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Use when revising an ACM CCS paper for a precise threat model, calibrated attack/defense claims, 12-page ACM sigconf compression, double-blind wording, adaptive-evaluation honesty, and the security house style that survives an adversarial SIGSAC program committee.

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Use when strengthening ACM CCS reproducibility evidence, including the artifact-availability posture, threat-model-to-evidence mapping, attack reproduction steps, defense overhead measurement, measurement-dataset provenance, environment and version pinning, and honest justification when artifacts cannot be shared.

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Use when designing or auditing the experiments of an ACM MM (ACM Multimedia) paper — matched baselines per modality, ablations that isolate the cross-modal fusion, user studies or QoE measurement where the claim is subjective, dataset and media licensing, and honest compute reporting, so evidence supports a multimedia claim.

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Use when the empirical identification strategy is the bottleneck for a 《会计研究》 (Accounting Research) manuscript — exogenous standard / regulatory changes (event study, DID), PSM, Heckman, IV — and you need to stress-test the design before drafting tables. Prefers standard/regulatory shocks as the cleanest accounting identification source.

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Prepare for investor calls by pulling upcoming meetings from Google Calendar, deeply researching each investor and their firm (website scraping, portfolio analysis, thesis extraction), checking for competitor conflicts, and outputting an honest prep sheet with compatibility assessments. Use when asked to prep for investor meetings, fundraising calls, VC meetings, or demo day.

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Extract structured data matching a JSON schema from websites. Handles complex nested schemas, arrays, pagination, and validation. Always outputs via formatOutput.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Renders Hi-C contact matrices honestly and reproducibly with matplotlib, cooltools, HiCExplorer, pyGenomeTracks, FAN-C, CoolBox, and plotgardener. Covers the raw/ICE-balanced/observed-over-expected transform choice, LogNorm vs symmetric-diverging colormaps with vmax/percentile clipping, resolution-to-feature matching (compartments 100-500kb, TADs 10-40kb, loops 5-10kb), square vs rotated-triangle track-stacking, NaN/white-stripe handling, virtual 4C, APA/saddle/on-diagonal pileups, two-condition side-by-side and log2-ratio maps, and interactive (HiGlass) vs scripted-static publication figures. Use when plotting a contact matrix, choosing a normalization or color scale, building a multi-track Hi-C figure, making a virtual 4C profile, piling up loops/boundaries, or comparing two conditions.

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Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish, Polypolish and pypolca (Illumina, repeat-aware), Pilon (legacy short-read), NextPolish/NextPolish2, Hapo-G (haplotype-aware), ntEdit, and DeepPolisher/PEPPER-Margin-DeepVariant for human. Covers the do-not-polish-HiFi rule, the medaka basecaller-model footgun, held-out Merqury QV as the only honest stop signal, and the haplotype-collapse trap. Use when correcting homopolymer indels or residual SNPs in a long-read assembly, deciding if a HiFi assembly needs polishing, or choosing an ONT vs hybrid vs short-read polishing chain.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。