「ker」の検索結果

Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

日本語の概要は準備中です。原文の説明を表示しています。

Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

日本語の概要は準備中です。原文の説明を表示しています。

Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

日本語の概要は準備中です。原文の説明を表示しています。

Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 and Bergquist 2025 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions SPM resolution failures, "no such module" errors, duplicate symbol linker errors, version conflicts between packages, or Swift 6 package compatibility issues.

日本語の概要は準備中です。原文の説明を表示しています。

Build SwiftUI layouts using stacks, grids, lists, scroll views, forms, and controls. Covers VStack/HStack/ZStack, LazyVGrid/LazyHGrid, List with sections and swipe actions, ScrollView with ScrollPosition and scroll-driven reveal surfaces, Form with validation, Toggle/Picker/Slider, .searchable, and overlay patterns. Use when building data-driven layouts, collection views, paged detail reveals, settings screens, search interfaces, or transient overlay UI.

日本語の概要は準備中です。原文の説明を表示しています。

Access eligible Wallet financial data using FinanceKit and FinanceKitUI. Use when querying transactions or balances, reading Apple Card, Apple Cash, Savings, or U.K. connected-account data, requesting financial-data authorization, using TransactionPicker, enabling iOS 26 background delivery, or saving and checking Wallet orders.

日本語の概要は準備中です。原文の説明を表示しています。

Discover and configure Bluetooth and Wi-Fi accessories using AccessorySetupKit. Use when presenting a privacy-preserving accessory picker, defining discovery descriptors for BLE or Wi-Fi devices, handling accessory session events, migrating from CoreBluetooth permission-based scanning, or setting up accessories without requiring broad Bluetooth permissions.

日本語の概要は準備中です。原文の説明を表示しています。

Implement, review, or improve maps and location features in iOS/macOS apps using MapKit and CoreLocation. Use when working with Map views, annotations, markers, polylines, user location tracking, geocoding, reverse geocoding, search/autocomplete, directions and routes, geofencing, region monitoring, CLLocationUpdate async streams, or location authorization flows. Also use when working with maps, coordinates, addresses, places, directions, distance calculations, or location-based features in Swift apps.

日本語の概要は準備中です。原文の説明を表示しています。

Add Apple Pencil drawing with PKCanvasView, PKToolPicker, PKDrawing serialization/export, stroke inspection, and PencilKit/PaperKit handoffs. Use when building drawing apps, annotation features, handwriting capture, signature fields, content-version-safe ink workflows, or Apple Pencil-powered experiences on iOS/iPadOS/visionOS.

日本語の概要は準備中です。原文の説明を表示しています。

Audits App Store submission readiness and rejection risk across current review guidelines, PrivacyInfo.xcprivacy and required-reason APIs, privacy labels, ATT, StoreKit payments, metadata, entitlements, widgets, and Live Activities. Use when preparing a submission, responding to rejection, reconciling privacy evidence, or separating upload blockers from cleanup.

日本語の概要は準備中です。原文の説明を表示しています。

Build direct Bluetooth Low Energy workflows with Core Bluetooth. Use when implementing BLE central or peripheral GATT communication, scanning or connecting with CBCentralManager, discovering services and characteristics, reading/writing/subscribing with CBPeripheral, publishing local services with CBPeripheralManager, handling Bluetooth authorization, background BLE modes, state restoration, write flow control, or CBUUID-based workflows. For privacy-preserving accessory setup/picker flows, use accessorysetupkit first and return here for post-setup GATT communication.

日本語の概要は準備中です。原文の説明を表示しています。

Read, create, update, and pick contacts using the Contacts and ContactsUI frameworks. Use when fetching contact data, saving new contacts, wrapping CNContactPickerViewController in SwiftUI, handling contact permissions, or working with CNContactStore fetch and save requests.

日本語の概要は準備中です。原文の説明を表示しています。

Implement, review, or improve CloudKit and iCloud sync in iOS/macOS apps. Use when working with CKContainer, CKRecord, CKQuery, CKSubscription, CKSyncEngine, CKShare, NSUbiquitousKeyValueStore, or iCloud Drive file coordination; when syncing SwiftData models via ModelConfiguration with cloudKitDatabase; when handling CKError codes for conflict resolution, network failures, or quota limits; or when checking iCloud account status before performing sync operations.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Divide one accepted work group only when at least two useful workers can have non-overlapping ownership.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-independent-checker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。

Report the compatibility redirect to `ap-worker`; this retired role cannot perform new work.

日本語の概要は準備中です。原文の説明を表示しています。