「how」の検索結果

Use this skill when the user asks to summarize, or asks why Simulink Coverage objectives are missing, unsatisfied, or uncovered on a coverage result they already have — why specific decision, condition, MCDC, relational-boundary, or saturation/overflow outcomes weren't exercised, whether uncovered logic is dead code, or how to close the gap (a test, a coverage filter, or a design change). It reads an existing cvdata, .cvt file, sim-with-coverage output, or Simulink Test result; it never runs cvsim to collect coverage.

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Analyze code coverage and CRAP (Change Risk Anti-Patterns) scores to identify high-risk code. Use OpenCover format with ReportGenerator for Risk Hotspots showing cyclomatic complexity and untested code paths.

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Build reactive/event-driven C# with R3 (Cysharp's modern reimplementation of Reactive Extensions). Covers the Observable<T>/Observer<T> model, the OnErrorResume error contract, async dispatch with AwaitOperation, Task/IAsyncEnumerable integration, TimeProvider/FrameProvider scheduling, the concurrency contract, and how R3 differs from System.Reactive (Rx.NET).

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Understand implementation details of .NET code by decompiling assemblies. Use when you want to see how a .NET API works internally, inspect NuGet package source, view framework implementation, or understand compiled .NET binaries.

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Analyzes code files and reports statistics including line counts, file counts by extension, and total size. Use this skill whenever the user wants to understand the composition of a codebase - asking about "how many lines of code", "what file types exist", "code distribution", or needing a quick audit of project size and structure. Make sure to invoke this skill when users mention analyzing codebases, counting lines, checking file distributions, or auditing code.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

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Assigns GO terms, Pfam/InterPro domains, KEGG orthologs, EC numbers, and product names to predicted proteins using eggNOG-mapper (orthology), InterProScan (domain signatures), and KofamScan (KEGG), routing specialized functions to dbCAN/antiSMASH/AMRFinderPlus/SignalP. Covers the orthology-vs-domain-vs-homology paradigms, the annotation-error percolation cascade, domain-presence-is-not-function, GO IEA circularity in enrichment, evidence tiering, and bit-score/coverage thresholds. Use when adding functional annotation to predicted genes, choosing between eggNOG-mapper and InterProScan, or judging how much to trust a functional label.

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Profiles a genome from raw reads BEFORE assembly with a k-mer spectrum (KMC or Jellyfish histogram), then models it with GenomeScope2 to estimate genome size, heterozygosity, repeat content, and ploidy, and Smudgeplot to infer ploidy from heterozygous k-mer pairs (diploid AB vs triploid AAB vs tetraploid AABB). Covers choosing k via Merqury best_k.sh, the k-mer-coverage vs sequencing-coverage confusion, reading het/repeat/contamination/organelle peaks, why noisy ONT must not be used for counting, and how the estimate becomes the NG50 denominator, the Flye -g value, the hifiasm --hom-cov/purge setting, and the 1.5-2x-too-big haplotig sanity check. Use when starting any de novo assembly, deciding whether short reads can work, estimating genome size for an unknown organism, diagnosing ploidy, or sanity-checking an assembly's size against expectation.

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Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish, Polypolish and pypolca (Illumina, repeat-aware), Pilon (legacy short-read), NextPolish/NextPolish2, Hapo-G (haplotype-aware), ntEdit, and DeepPolisher/PEPPER-Margin-DeepVariant for human. Covers the do-not-polish-HiFi rule, the medaka basecaller-model footgun, held-out Merqury QV as the only honest stop signal, and the haplotype-collapse trap. Use when correcting homopolymer indels or residual SNPs in a long-read assembly, deciding if a HiFi assembly needs polishing, or choosing an ONT vs hybrid vs short-read polishing chain.

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Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Plot per-gene mutation distributions on a protein-domain map (lollipop / needle plots) showing mutation position, recurrence count, and variant classification with maftools, g3-lollipop, trackViewer, and ProteinPaint. Use when visualizing recurrent mutation hotspots on a single gene's protein, marking domain boundaries from UniProt/Pfam, comparing missense vs truncating distributions, or contrasting two cohorts on the same lollipop.

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Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2. Covers clonal versus subclonal copy-number states, haplotype phasing for subclonal resolution, cancer cell fraction, whole-genome-doubling detection and timing relative to mutations, mirrored subclonal allelic imbalance, and copy-number phylogenies. Use when a tumor is heterogeneous and bulk data shows non-integer copy number, when calling subclonal CNAs, detecting or timing whole-genome doubling, reconstructing copy-number evolution, or deciding between Battenberg and TITAN.

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Creates sashimi-style plots showing RNA-seq read coverage and splice junction counts using ggsashimi (general-purpose, condition-grouped overlays), rmats2sashimiplot (rMATS-output-aware), MAJIQ-VOILA (LSV posteriors interactive HTML), leafviz (leafcutter clusters Shiny), Jutils (tool-agnostic heatmaps and sashimi for rMATS/leafcutter/MntJULiP/MAJIQ output), or pyGenomeTracks (multi-track publication figures). Tool choice depends on the upstream differential-splicing tool's output format and the publication vs interactive use case. Use when visualizing specific splicing events, validating differential splicing calls, or producing publication-quality figures.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Fetch WeatherKit current, minute, hourly, and daily forecasts; weather alerts; iOS 18+ changes, historical comparisons, summaries, and statistics; and required Apple Weather attribution. Use when integrating weather data, showing forecasts or alerts, caching WeatherKit responses, displaying attribution, or reviewing WeatherKit query limits in iOS apps.

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Integrate Game Center features using GameKit. Use when authenticating GKLocalPlayer, checking player restrictions, submitting leaderboard scores, reporting achievements, implementing real-time or turn-based matchmaking, handling GKMatch data, showing the Game Center dashboard or access point, adding challenges and friend invitations, saving game data, or verifying player identity on a server.

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Display and manipulate PDF documents using PDFKit. Use when embedding PDFView to show PDF files, creating or modifying PDFDocument instances, adding annotations (highlights, notes, signature widgets), extracting text with PDFSelection, navigating pages, generating thumbnails, filling PDF forms, or wrapping PDFView in SwiftUI.

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Build investor-ready pitch scripts in multiple formats (10-min, 5-min, 2-min, 1-min elevator, investor email). Produces pitch narratives, Q&A preparation, pitch scoring rubric, and optional investor roleplay practice. Use when the user wants to create a pitch, prepare for investor meetings, craft a startup pitch, write a fundraising narrative, or practice their pitch. Triggers for "pitch deck", "investor pitch", "pitch my startup", "fundraising deck", "seed deck", "how to pitch", "investor meeting", "demo day", "prepare pitch", "pitch script", "elevator pitch for investors", "pitch practice", "practice my pitch", "investor roleplay", or any request to present a startup to investors, accelerators, or partners. Works standalone — no prior startup-design session needed, but leverages its output if available.

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Answer Viking AI Search product questions, CLI usage questions, API/auth questions, configuration questions, and troubleshooting questions by grounding every claim in either the installed `vs` CLI's own output or official Volcengine documentation. Never fabricate.

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Generate read-only MongoDB queries (find) or aggregation pipelines using natural language, with collection schema context and sample documents. Use this skill whenever the user asks to write, create, or generate MongoDB queries, wants to filter/query/aggregate data in MongoDB, asks "how do I query...", needs help with query syntax, or discusses finding/filtering/grouping MongoDB documents. Also use for translating SQL-like requests to MongoDB syntax. Does NOT handle Atlas Search ($search operator), vector/semantic search ($vectorSearch operator), fuzzy matching, autocomplete indexes, or relevance scoring - use search-and-ai for those. Does NOT analyze or optimize existing queries - use mongodb-query-optimizer for that. Does NOT handle aggregation pipelines that involve write operations. Requires MongoDB MCP server.

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Use when planning or restructuring what pages a site has and how they connect: hierarchy, navigation, URL patterns, breadcrumbs, and internal linking. Not for XML sitemaps, which are in seo-audit.

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This skill should be used when user asks to "upload my model to Ultralytics Platform", "push this run to the platform", "upload a dataset to platform", "download a dataset from platform", "search platform datasets", "start cloud training", "train on platform GPUs", "export a model on platform", "deploy a model endpoint", "run Moondream on Platform", "auto-annotate a Platform dataset", "run hosted AI inference", "why is my run not showing on platform", or mentions platform.ultralytics.com, ul:// URIs, ultralytics-platform, or ULTRALYTICS_API_KEY.

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