「assumption」の検索結果

Turn a brand's facts, a campaign brief and the product into a one-minute Meta ad strategy with its reasoning — goal, audience, objective and placements, budget split, how many ads and how different they must be (generate 3x so the user can choose), the test frame, the success metric, and safety rules for the user to accept. Decides what launch-meta-ad-campaign then executes, and re-reads the strategy after a deep check to show which assumption changed. Use it after intake and before any creative is generated or any campaign is built.

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Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.

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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.

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Phases small variants, SVs, and methylation from Oxford Nanopore and PacBio long reads (read-backed/physical phasing) with WhatsHap, LongPhase, or HiPhase, and haplotags the BAM (HP/PS tags) for allele-resolved downstream analysis. Covers why phase blocks break at het-sparse gaps (read length x heterozygosity), why phasing the VCF is useless until the BAM is haplotagged, the GT-pipe/PS and read HP/PS tag spec, reporting block N50 with switch error, the diploid-assumption/CNV/haploid-region traps, trio phasing as the gold standard, and the boundary to statistical panel phasing. Use when phasing long-read variants, haplotagging reads for allele-specific methylation/expression or phased SVs, choosing WhatsHap vs LongPhase vs HiPhase, trio phasing, or assessing phasing quality.

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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Apply systematic problem-solving techniques when stuck. Use for complexity spirals, innovation blocks, recurring patterns, assumption constraints, simplification cascades, scale uncertainty.

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Applied statistics for business and product questions — test selection, assumption checks, power planning, effect sizes with intervals, multiplicity correction. Use when interpreting an experiment, sizing a study, or vetting a claim.

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Scope management for legal matters — baseline capture, in-flight change control, OOS documentation, and scope retrospective. Use when asked to review scoping assumptions, assess whether work is in or out of scope, draft a scope change notice, track scope changes, prepare an OOS justification, run an OOS report, prepare a scope call agenda, or review what changed on a matter. Trigger on: 'scope change', 'out of scope', 'OOS', 'scope creep', 'is this in scope', 'the client wants us to also', 'additional work', 'scope review', 'what changed from the original scope', 'we need to revisit the quote', 'the budget assumed', 'OOS report', 'scope call with the client', 'run a scope report'.

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This skill stress-tests a proposed settlement position before an offer goes out or comes back: the assumptions it depends on, your leverage and the opponent’s, the evidential weaknesses, the likely opponent response, and the timing and costs pressures around it. It structures settlement judgment for a better-informed decision; it does not advise whether to settle.

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No Inference / Source-Locked Verification. Forces Claude to answer ONLY from user-provided materials and/or online sources actually accessed — no inference, no assumptions, no gap-filling. Every factual, legal, numerical, or procedural claim must be anchored to a cited source. Use whenever Claude reviews documents, summarises evidence, checks accuracy, drafts submissions, creates timelines, extracts facts, checks citations, analyses rules, prepares legal arguments, compares documents, verifies claims, produces chronologies, works from uploaded materials, performs legal research, checks case status, or does anything where evidential fidelity matters. Also trigger on: 'source-locked', 'no inference', 'only from the materials', 'don't assume', 'stick to the evidence', 'verify this', 'check this is right', 'work from the documents'. Overrides Claude's default tendency to fill gaps. If evidential accuracy matters, use this skill.

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Audits legal AI outputs, prompts, skills, workflows and MCP/tool instructions for fluent but unsupported reasoning, missing evidence, overconfidence, hidden assumptions, weak causal links and absent human-review gates.

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Use for due diligence, legal-financial risk review, investment or business transaction checklists, and preliminary screening where facts, documents, assumptions, legal uncertainty, debt/equity, assets/liabilities, contracts, tax, regulatory, compliance, technology/product, and financial-model issues must be separated clearly.

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When a solution seems impossible and the path forward is blocked. Refuses to take no for an answer: classifies what kind of "no" you hit, then runs lateral-thinking techniques (assumption autopsy, inversion, first principles, constraint toggling, analogical transfer, and more) until the wall cracks or is proven load-bearing. Generates at least 10 angles before evaluating any. AGENTS: use this on yourself when an API doesn't support what you need, an approach has failed twice, or a "that's not possible" sentence is forming — run the fast path BEFORE reporting a dead end. Archives walls to ~/.config/makerskills/unstuck/archive/. Sits upstream of decide. Triggers on "/unstuck," "I'm stuck," "this seems impossible," "we hit a wall," "there's no way to," "they said no," "dead end," "out of options," "I've tried everything," "work around this."

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Flip core assumptions to reveal hidden constraints and alternative approaches - "what if the opposite were true?"

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Teaches agents how to run a timeboxed spike - throwaway code that validates one assumption before DESIGN

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Runs a timeboxed PROBE to validate one core assumption, then optionally PROMOTES the probe into a walking skeleton — the first e2e thin slice of the feature, committed and demo-able. Use after DISCUSS when the feature involves a new mechanism, performance requirement, or external integration.

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Mom Test questioning toolkit, JTBD analysis, interview conduct, assumption testing framework, and hypothesis design

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Conducts evidence-based product discovery through customer interviews and assumption testing. Use at project start to validate problem-solution fit.

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Monthly, on the last weekday. Folds a month of the creative ledger against the daily metrics ledger to score angle, format, hook, and offer framing rather than individual files, tests every line currently in the creative doctrine against what the month actually measured, and rewrites the doctrine where the evidence disagrees with the assumption. It records the fatigue curve it observed, retires what has not earned, and changes nothing where the month holds too few rows to tell one angle from another.

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Monthly on the last weekday, light browser lane. Re-tests every theme and every severity rule against a month of real ticket evidence and rewrites strategy/themes.md wherever the evidence disagrees with the assumption. It merges two themes the evidence shows are one, splits a theme whose tickets have two different answers, retires a theme with no volume, creates a theme for a cluster that kept landing unclassified, and rewrites a severity rule wherever the outcomes contradict it. Theme ids are never reused and never renumbered. It holds every outbound action unless you released the channel, and it never touches a credential.

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Monthly, on the last weekday, light browser lane. Re-tests every named qualification test and every buyer segment against a month of this kit's own ledger evidence, then rewrites both files itself where the evidence disagrees with the assumption they were written on. It records every change in strategy/CHANGELOG.md with the ledger path that justified it. It sends only where you released the channel, never re-queues anyone, never edits the contacted ledger, and never writes a number it did not count out of a named file.

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Monthly, on the last weekday. Re-tests every segment in strategy/icp.md against the evidence in this kit's own ledgers, then rewrites the targeting itself where the evidence disagrees with the assumption the segment was written on. It records every change in strategy/CHANGELOG.md. It sends only where you released the channel, never re-queues anyone, never edits the contacted ledger, and never writes a number it did not read out of a named file.

日本語の概要は準備中です。原文の説明を表示しています。