「dpo」の検索結果

Generate a polished frontend reference screenshot through a configurable GPT-image-2-compatible generations endpoint, save and show versioned previews inside the project, revise selected previews through a configurable /images/edits endpoint, and reproduce only the user-approved design as functional frontend code with high visual fidelity. Use when Codex is asked to design, build, restyle, or recreate a web page, application screen, dashboard, landing page, or UI component through an image-first workflow, design approval loop, screenshot-driven implementation, pixel matching, or a 1:1 frontend recreation.

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Use this skill when creating or reviewing Next.js Route Handlers (app/api), adding rate limiting, input validation, or auth to API endpoints. Trigger words: API ルート, Route Handler, app/api, エンドポイント, レート制限, 入力検証, CORS, ヘッダー, 認証付き API, hardening.

Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability.

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Discover and inventory shadow API endpoints that operate outside documented specifications using traffic analysis, code scanning, and API discovery platforms.

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Use when adding or changing REST endpoints or the OpenAPI contract — deriving endpoints from the Lean commands and views, writing documents/codebase/openapi.yaml first, then regenerating the backend controller interfaces and the frontend client.

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Execute model inference on GPU cloud providers. Handles code generation, deployment, execution, and result collection across HF Inference API/Endpoints, Colab, Modal, beam.cloud, Vast.ai, and RunPod. Use when running models on GPU, deploying to cloud, executing notebooks, or troubleshooting GPU execution failures. Triggers on "run on GPU", "execute model", "deploy to modal", "colab notebook", "beam deploy", "HF inference", "HF endpoints", "vast", "runpod".

日本語の概要は準備中です。原文の説明を表示しています。

Discover and inventory shadow API endpoints that operate outside documented specifications using traffic analysis, code scanning, and API discovery platforms.

日本語の概要は準備中です。原文の説明を表示しています。

Detects fileless malware and in-memory attacks that execute entirely in RAM without writing persistent files to disk, evading traditional antivirus. Use when building detections for PowerShell-based attacks, reflective DLL injection, WMI persistence, and registry-resident malware. Activates for requests involving fileless malware detection, in-memory attacks, PowerShell exploitation, or living-off-the-land techniques.

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Design and implement scalable API gateways, RESTful APIs, GraphQL endpoints, WebSocket handlers, and microservice communication patterns. Use when creating API routes, designing endpoints, implementing middleware, or setting up service mesh architectures.

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Strategic clinical trial design feasibility assessment. Analyzes 6 dimensions (endpoint, population, comparator, effect size, duration, regulatory pathway) using precedent trials and FDA guidance. Produces enrollment projections, endpoint recommendations, and approval-pathway analysis. Use for trial-protocol design, power/sample-size estimation, comparator selection, and FDA submission strategy. Driven by precedent-based reasoning rather than first-principles math.

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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

日本語の概要は準備中です。原文の説明を表示しています。

High-performance RLHF framework with Ray+vLLM acceleration. Use for PPO, GRPO, RLOO, DPO training of large models (7B-70B+). Built on Ray, vLLM, ZeRO-3. 2× faster than DeepSpeedChat with distributed architecture and GPU resource sharing.

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Fine-tune LLMs using reinforcement learning with TRL - SFT for instruction tuning, DPO for preference alignment, PPO/GRPO for reward optimization, and reward model training. Use when need RLHF, align model with preferences, or train from human feedback. Works with HuggingFace Transformers.

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Expert guidance for fine-tuning LLMs with Axolotl - YAML configs, 100+ models, LoRA/QLoRA, DPO/KTO/ORPO/GRPO, multimodal support

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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OpenAI API (developers.openai.com) の Evals / Fine-tuning リファレンス。 Evals API, Datasets, graders（string check, text similarity, model, python, multi）, agent evals, trace grading, external models、 SFT, DPO, RFT（reinforcement fine-tuning）, vision fine-tuning, distillation, prompt optimizer, fine-tuning best practices。 セルフサービス fine-tuning は段階的廃止進行中。

Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

日本語の概要は準備中です。原文の説明を表示しています。

Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

日本語の概要は準備中です。原文の説明を表示しています。

Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants a backend-only action plan — API endpoints, services, models, migrations, jobs and their tests — 'plano de backend para o endpoint X', 'plan the orders API'. Writes .planning/feat/features/{slug}/plan.md with the PWDEVIA method. Do NOT use for UI work (feat-frontend), full features spanning backend and UI (feat-feature), writing code (feat-exec) or quick 1–3 file fixes (feat-quick).

日本語の概要は準備中です。原文の説明を表示しています。

Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability.

日本語の概要は準備中です。原文の説明を表示しています。

Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

日本語の概要は準備中です。原文の説明を表示しています。