「estimate」の検索結果

Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Generate Bluetooth Low Energy (BLE) PHY waveforms. Read BEFORE writing any BLE waveform code to avoid hallucinating API patterns. Covers bleWaveformGenerator, bleIdealReceiver, bleCTEIQSample, bleAngleEstimate, bluetoothTestWaveform for LE1M/LE2M/LE500K/LE125K. Bluetooth Toolbox R2022a+.

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Integrate antennas into RF systems using MATLAB Antenna Toolbox and RF Toolbox. Covers impedance matching network design (L/Pi/Tee topologies, evaluation parameters, Richards transformation), measured antenna creation (E-field, directivity-only, EmbeddedE, ffsReader import), RF propagation and site planning (txsite/rxsite, coverage, SINR, ray tracing, link budget), and SAR estimation (birdcage+Phantom, conformalArray+Custom3D, direct EHfields). Use when the user wants to match an antenna, create a measuredAntenna, compute coverage or signal strength, perform ray tracing, or estimate SAR.

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Fit SimBiology model parameters to data — fitproblem, population NLME, virtual patients, and NCA. Use when asked to fit, estimate, calibrate, or compute PK metrics.

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Evaluate ecommerce price candidates using unit economics, historical observations, elasticity analysis, scenario modeling, and controlled experiments. Use when a seller asks what price to test, how price changes could affect contribution or revenue, how to estimate elasticity, how to optimize a bundle or tier, or how to design a price experiment across Amazon, Shopify, TikTok Shop, Walmart, eBay, or other channels. Do not claim a proven optimal price without sufficient clean data, and do not change live prices without explicit authorization.

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Estimate the dollars saved by routing eligible Claude Code work to a cheaper model family, using the Agent Monitor pricing engine. Re-prices each model's token mix at the target family's rates and quantifies the delta. Uses /api/pricing (rates), /api/pricing/cost (current per-model spend), /api/sessions, and /api/analytics. Use when hunting for cost cuts or comparing model tiers.

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Expert guidance for the Fabric CLI (`fab`) and the Fabric and Power BI REST APIs: workspaces, items, lakehouses, notebooks, pipelines, semantic models, reports, capacities, OneLake, deployment and admin. Also estimates the capacity units (CU) an operation will consume and its impact on the capacity before running it. Automatically invoke whenever the user mentions Fabric, Power BI Service, a Fabric or Power BI workspace, a capacity or F SKU, OneLake, `fab`, or asks to create, run, refresh, schedule, deploy or delete anything in Fabric, including preview items such as Plan, Ontology, Graph or Copilot.

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Use when generated assets must keep a consistent style, character, or product look and references stop scaling, or when a user asks to train a custom model through the Scenario MCP, fine-tune a LoRA, clone a voice, curate a training dataset, choose a base model, set epochs and sample prompts, estimate training cost, diagnose a trained model that lost its identity or has one epoch, or generate with a trained model. Keywords: custom model, LoRA, dataset curation, epoch previews.

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Effort breakdown and estimation

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Deploy applications to AWS. Triggers on phrases like: deploy to AWS, host on AWS, run this on AWS, AWS architecture, estimate AWS cost, generate infrastructure. Analyzes any codebase and deploys to optimal AWS services.

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This skill should be used when the user asks to "estimate LLM costs", "count tokens in prompts", "optimize prompt token usage", "compare model pricing", or "reduce LLM API costs".

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This skill should be used when the user asks to "batch LLM requests", "should I use the batch API", "estimate batch vs realtime cost", "design a bulk LLM job", or "process thousands of prompts cheaply".

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Run a quick what-if on 2-4 budget scenarios with revenue and ROI estimates. "compare two budget splits"

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Simulate scenarios by Monte Carlo: P10-P90 revenue, odds of target. Quick estimate → what-if. "simulate next quarter's revenue"

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File Indian income tax returns for FY 2025-26 (AY 2026-27), or plan FY 2026-27 (Tax Year 2026-27), including current-year advance-tax estimates. Use when the user wants to file their ITR, compute or verify Indian income tax, compare the old vs new tax regime, read a Form 16, AIS, TIS or Form 26AS, reconcile TDS, handle capital gains from Zerodha/Groww/Upstox statements, check their tax refund, or asks about ITR-1/ITR-2/ITR-3/ITR-4, sections 80C/80D/87A/111A/112A, crypto tax, advance tax, or the income-tax e-filing portal - even if they just say "help me with my taxes" in an Indian context.

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Analyzes how multiple regulations interact for a specific product, service, or business model. Identifies where obligations overlap, reinforce, complement, duplicate, or conflict; builds a priority matrix; produces an integrated compliance timeline; and estimates the total compliance burden. Use when (1) scoping a new product or service against the full regulatory landscape before launch, (2) conducting M&A due diligence on a target's multi-regulation exposure, (3) building a strategic compliance roadmap where single-regulation analyses miss the interactions, (4) advising on complex situations where regulations touch the same conduct from different angles, or (5) estimating budget and resourcing for multi-regulation compliance. Primary coverage of EU digital regulation (GDPR, Data Act, AI Act, CRA, NIS2, DORA, DMA, DSA, ePrivacy) and national implementations; the framework extends to any jurisdiction where overlapping regulatory regimes apply to the same activity.

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Design metacognitive checkpoints that prevent AI-assisted learning from bypassing genuine understanding. Use when students use AI tools and may overestimate their own comprehension.

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Audit a project's infrastructure and SaaS stack, then produce a cost report showing what the user currently pays and what they would save by consolidating onto Temps (self-hosted or Temps Cloud). Detects hosting platforms (Vercel, Netlify, Railway, Render, Heroku, Fly.io), analytics (PostHog, Plausible, Mixpanel, Amplitude, Fathom), error tracking (Sentry, Bugsnag, Rollbar, Honeybadger), session replay (LogRocket, FullStory, Hotjar, Highlight), uptime monitoring (Pingdom, UptimeRobot, Better Stack, Checkly), managed databases (Supabase, Neon, PlanetScale, MongoDB Atlas, Upstash, RDS), and transactional email (SendGrid, Postmark, Resend, Mailgun) from dependencies, config files, and env var names. Use when the user wants to: (1) Know how much they would save by switching to Temps, (2) Audit their SaaS/infrastructure spend, (3) Compare their current stack's cost against self-hosting, (4) Decide whether Temps is worth it, (5) Build a business case for consolidating tools. Triggers: "how much would I save", "temps savings", "cost comparison", "audit my stack", "am I overpaying", "saas spend", "calculate savings", "is temps cheaper".

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Update A-share financial models with new quarterly data, management guidance, or macro changes. Reflects actuals, rolls estimates forward, flags material changes, and updates valuation. Adapted from the original model-update skill for Chinese market conventions and AkShare data. Triggers on "A股模型更新", "模型更新", "plug earnings into model", "update model for [company]", "刷新预测", or "更新财务模型".

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SpotClean is a computational method to adjust for spot swapping in spatial transcriptomics data. Recent spatial transcriptomics experiments utilize slides containing thousands of spots with spot-specific barcodes that bind mRNA. Ideally, unique molecular identifiers at a spot measure spot-specific expression, but this is often not the case due to bleed from nearby spots, an artifact we refer to as spot swapping. SpotClean is able to estimate the contamination rate in observed data and decontamin

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Fit linear models to overdispersed count data. The package can estimate the overdispersion and fit repeated models for matrix input. It is designed to handle large input datasets as they typically occur in single cell RNA-seq experiments.

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Uses DESeq2 to estimate variance-mean dependence in count data from high-throughput sequencing assays and test for differential expression based on a model using the negative binomial distribution.

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