「signal」の検索結果

Execute ENCODE ChIP-seq processing pipeline from FASTQ to peaks and signal tracks. Child of pipeline-guide. Provides stage-by-stage Nextflow execution with Docker containers and cloud deployment. Use when users need to process ChIP-seq data following ENCODE standards, run peak calling with MACS2, perform IDR analysis, or generate signal tracks. Trigger on: ChIP-seq pipeline, run ChIP-seq, process ChIP-seq, MACS2 peak calling, IDR analysis, ChIP-seq FASTQ processing.

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Comprehensive guide for visualizing ENCODE data including deeptools heatmaps, IGV screenshots, UCSC track hubs, and publication-quality plots. Use when users need to create visualizations of ChIP-seq signal, peak landscapes, genome browser views, or any visual representation of ENCODE data. Trigger on: heatmap, visualization, genome browser, track hub, IGV, deeptools, signal plot, peak visualization, profile plot, publication figure, bigWig visualization.

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Standalone E-E-A-T scoring rubric for a URL or content draft. Scores Experience, Expertise, Authoritativeness, and Trust 0-5 each using concrete detectable signals, framed per Google's creating-helpful-content doc. Use when user says "E-E-A-T", "EEAT", "experience expertise", "trust signals", or "author authority".

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Local SEO audit covering NAP consistency, local schema markup, Google Business Profile signals, local content, citations, review signals, and mobile optimization. No MCP required — fetches pages via WebFetch. Use when user says "local SEO", "Google Business Profile", "GBP", "NAP consistency", "local citations", "local schema", "local pack", "map pack".

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Audit and fix agent readiness: the Lighthouse Agentic Browsing fraction, accessibility tree for agents, robots.txt and Content-Signal for AI agents, WAF treatment of agent traffic, llms.txt, Markdown delivery, ai-catalog.json, /.well-known discovery files, and WebMCP tools. Exclude AI citability and brand signals (seo-geo) and commerce protocol depth (seo-ecommerce).

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Use Tanso, an AI Search CLI for exploring Chinese internet signals. Use when the user asks to search Chinese web sources, Zhihu, Zhihu hotlists, Bocha, Volcengine Ark, Chinese internet topics, source-backed briefs, contradiction checks, counterintuitive topic discovery, popular answers, live provider testing, or current Chinese web signals.

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Generates Angular code and provides architectural guidance. Trigger when creating projects, components, or services, or for best practices on reactivity (signals, linkedSignal, resource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, or CLI tooling.

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Implement HTTP data fetching in Angular v20+ using resource(), httpResource(), and HttpClient. Use for API calls, data loading with signals, request/response handling, and interceptors. Triggers on data fetching, API integration, loading states, error handling, or converting Observable-based HTTP to signal-based patterns.

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Create modern Angular standalone components following v20+ best practices. Use for building UI components with signal-based inputs/outputs, OnPush change detection, host bindings, content projection, and lifecycle hooks. Triggers on component creation, refactoring class-based inputs to signals, adding host bindings, or implementing accessible interactive components.

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Write unit and integration tests for Angular v20+ applications using Vitest or Jasmine with TestBed and modern testing patterns. Use for testing components with signals, OnPush change detection, services with inject(), and HTTP interactions. Triggers on test creation, testing signal-based components, mocking dependencies, or setting up test infrastructure. Don't use for E2E testing with Cypress or Playwright, or for testing non-Angular JavaScript/TypeScript code.

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Use when working with Angular code — components, signals, services, forms, routing, HTTP, testing, SSR, or tooling. Targets Angular v20+ modern patterns. Auto-activates on .ts files in Angular projects (detected via angular.json).

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Analyze reviewed Grafana log evidence for event patterns, error-rate changes, and enrolled security markers. Use when a user needs bounded log analytics for an incident window, error-log comparison, anomaly triage, operational debugging, or a cautious check of approved security signals.

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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.

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Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Generate conservative, editable English outreach drafts for foreign-trade sales from structured lead inputs and customer-intel signals. Use when an operator needs a first-touch or follow-up email draft that calls confirmed recent/customer-market signals from the customer-intel Skill, with subject options, review notes, and explicit reminders not to present unconfirmed facts as facts.

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Expert Clay platform consultant for B2B data enrichment and workflow automation. Use when the user asks about Clay tables, waterfall enrichment, Clay credits, Clay AI columns, Claygent, enrichment workflows, Clay integrations, Clay exports, Clay table design, lead scoring in Clay, or building data pipelines in Clay. Also triggers on "Clay table", "enrichment waterfall", "Clay credits", "Claygent", "Clay AI column", "Clay export", "Clay providers", "enrich in Clay", "Clay column", "Clay formulas", "find emails", "email waterfall", "phone waterfall", "lead scoring", "Clay debugging", "Clay troubleshoot". Do NOT use for general CRM questions without Clay context, cold email copy (use cold-email-copy-playbook), or signal routing (use buying-window-signal-workflow).

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Expert-level cell biology knowledge. Use when working with cell structure, organelles, cell signaling, cell cycle, cell division, cytoskeleton, membrane biology, vesicular trafficking, apoptosis, or cell biology techniques. Also use when the user mentions 'organelle', 'mitochondria', 'endoplasmic reticulum', 'Golgi', 'cytoskeleton', 'cell cycle', 'mitosis', 'meiosis', 'apoptosis', 'signal transduction', 'membrane potential', 'endocytosis', or 'cell migration'.

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Expert-level biochemistry from a biology perspective covering metabolic pathways, enzyme kinetics, bioenergetics, signal transduction, and the biochemical basis of cellular processes.

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Expert-level biochemistry knowledge. Use when working with proteins, enzymes, metabolism, DNA, RNA, carbohydrates, lipids, cell signaling, or bioenergetics. Also use when the user mentions 'enzyme kinetics', 'metabolism', 'glycolysis', 'Krebs cycle', 'DNA replication', 'protein folding', 'amino acids', 'ATP', 'oxidative phosphorylation', 'gene expression', 'lipid bilayer', or 'signal transduction'.

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Use when establishing what observability a project actually has — the four Golden Signals, required signal to detected implementation to evidence, and SLI/SLO provenance.

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Use when consolidating session signals into curated memory — four-phase loop ORIENT → GATHER → CONSOLIDATE → PRUNE. Triggers on 'mine my sessions', 'consolidate memory', 'review intake signals'.

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Generates Angular code and provides architectural guidance. Trigger when creating projects, components, services, or HTTP communication, or for best practices on reactivity (signals, linkedSignal, resource, httpResource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, naming conventions, or CLI tooling.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Angular code and provides architectural guidance. Trigger when creating projects, components, or services, or for best practices on reactivity (signals, linkedSignal, resource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, or CLI tooling.

日本語の概要は準備中です。原文の説明を表示しています。