408 件 ・ 関連度順
概要と使いどころ
Use when a task needs the judgment of a demographer — building a cohort-component population projection, reconciling fertility/mortality rate estimates against ACS or vital-statistics counts, judging whether a population trend is real or sampling/measurement noise, sizing a census undercount adjustment, or advising a public agency on age-structure-driven facility or service demand.
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Use when a task needs the judgment of a Bioinformatics Scientist — designing a differential-expression or GWAS analysis with correct multiple-testing correction, calling and triaging variants from NGS data using genotype-likelihood confidence rather than raw allele counts, interpreting a BLAST/DIAMOND homology search, choosing or building a genomics pipeline (aligner, caller, normalization method) for a specific data-generating process, or judging whether a computational-biology analysis's statistical design actually supports the biological claim being made. Distinct from a bioinformatics-technician (executes and QC-gates an established pipeline someone else designed) and a data-scientist (general product/experimentation judgment, not genomics-specific statistics) — this role owns which method and statistical model a genomics question requires, and why.
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Bayesian data analysis — priors, likelihoods, posterior computation, model comparison, and honest reporting.
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Statistical methods for biology and medicine — study design, hypothesis testing, regression, and survival analysis.
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Evidence-first academic research workflow for topic ideation, scholarly search, paper reading, literature and systematic reviews, study and experiment design, statistics and data analysis, scientific figures, manuscript drafting and polishing, citation checks, peer review, rebuttals, submission packages, theses, and paper-to-presentation work. Use when an agent must plan, execute, audit, write, revise, or package research while keeping claims traceable to verified sources, data, analysis, or official requirements.
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Diagnose why a landing page, homepage, pricing page, or signup form is not converting, and produce a ranked fix list with a test plan. Runs a structured audit across motivation, value clarity, friction, anxiety, and CTA hierarchy rather than giving generic design opinions. Use when the user says "why isn't this page converting", "improve our conversion rate", "CRO", "conversion audit", "this page isn't working", "high traffic low signups", "people bounce", "review our landing page", or shares a URL and asks what is wrong with it. For rewriting the words only, see copy-review. For writing a new page from scratch, see landing-page-writer. For the statistics of running the test afterwards, see growth-experiment.
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Write new blog articles from scratch optimized for Google rankings and AI citations. Generates full articles with template selection, answer-first formatting, Key Takeaways summary box, information gain markers, evidence-backed explanations, sourced statistics, Pixabay/Unsplash images, built-in SVG chart generation, optional FAQ sections, internal linking zones, and proper heading hierarchy. Supports MDX, markdown, and HTML output. Use when user says "write blog", "new blog post", "create article", "write about", "draft blog", "generate blog post".
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SERP-informed outline generation with H2/H3 heading hierarchy, competitive content gap analysis, section-by-section word count targets, chart and image placement markers, optional FAQ question planning, and internal linking zones. Skeleton only: structure, H2/H3 hierarchy, word counts, optional FAQ slots. Use blog-brief instead if you need full competitive analysis, statistics research, and image suggestions. Lighter than a full content brief, generates article skeleton and structure only, ready for /blog write to consume. Use when user says "outline", "blog outline", "content outline", "structure blog", "plan sections", "article skeleton", "heading structure", "SERP analysis", "competitive outline", "plan article".
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Rewrite and optimize existing blog posts for Google SEO (May 2026 Core Update, E-E-A-T) and AI citation visibility as one SEO discipline. For AI-citation-only audit (no Google work), use blog-geo instead. Replaces fabricated statistics with sourced data, applies answer-first formatting, adds images, generates SVG charts, and updates freshness signals. Works with any blog format (MDX, markdown, HTML). Use when user says "rewrite blog", "optimize blog", "update blog", "improve blog", "fix blog".
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Generate detailed content briefs for blog posts with target keywords, content outlines, competitive analysis, recommended statistics, image and chart suggestions, word count targets, internal linking architecture, template recommendations (12 types), TL;DR drafts, evidence-backed section planning, information gain prompts, and multi-channel distribution plans. Briefs are optimized for Google rankings and AI citation visibility as part of SEO. Use when user says "content brief", "blog brief", "write brief", "SEO brief", "article brief", or "content requirements".
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Control AdGuard Home DNS filtering via HTTP API. Use when managing blocklists/allowlists, checking domain filtering status, toggling protection, or clearing DNS cache. Supports blocking/allowing domains, viewing statistics, and protecting/disabling DNS filtering.
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🛡️ Query AdGuard Home instances for DNS statistics, blocked domains, and client activity 🛡️ 查询 AdGuard Home 实例的 DNS 统计、拦截域名和客户端活动
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法外功夫 — Non-legal business skills for lawyers. Decision analysis, game theory, contract design, accounting, finance, microeconomics, law & economics, statistics, and regression analysis distilled into deep, actionable frameworks for legal practice. Each domain includes formulas with LaTeX notation, worked examples, adversarial checklists, and book-aligned structure. | 律师必备的非法律商业技能深度参考：决策分析、博弈论、合同设计、会计、金融、微观经济学、法经济学、统计分析、多元回归。每章都包含完整公式推导、worked examples、对抗清单与经典判例。当用户涉及和解谈判、合同激励、财务尽调、企业估值、损害赔偿计算、反垄断分析、统计证据评估、歧视诉讼回归分析、hold-up、效率违约、Daubert 动议等场景时触发。
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Benchmark multi-agent coordination systems with experiment design, power analysis, human rating protocols, bootstrap confidence intervals, and reproducible reporting. Use for salvage latency, recovery fidelity, coordination overhead, and protocol comparison studies. NOT for ML model benchmarking, web-product A/B testing, survey design, or general-purpose data science.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Defines cell populations in flow and spectral cytometry through manual gates (rectangle, polygon, quadrant, boolean) and reproducible automated gating (openCyto gating templates, flowDensity data-driven thresholds, flowClust model-based gates), organized as a hierarchical GatingSet (flowWorkspace) and round-tripped with FlowJo via CytoML. Covers the canonical gate order (time -> debris -> singlets -> live -> lineage), FMO-vs-isotype boundary setting, gate-order dependence and recompute semantics, rare-event/MRD gating, and per-population statistics. Use when building a gating strategy, automating a manual FlowJo scheme across samples, choosing manual vs data-driven gates, or extracting population frequencies.
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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.
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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Build Manhattan, Miami, QQ, and locuszoom-style regional plots from GWAS, TWAS, PWAS, and QTL summary statistics with correct genomic-inflation diagnostics, multi-trait overlays, lead-SNP labeling, and LD-aware regional rendering. Use when visualizing association results across the genome, comparing two traits, computing genomic inflation lambda, or zooming into a locus with LD coloring.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Detect introgression and admixture between species or populations using Dsuite (Malinsky 2021 fast D-statistics), Patterson's D / ABBA-BABA test (Green 2010; Durand 2011), f4-ratio and f-branch statistic (Malinsky 2018), TreeMix (Pickrell & Pritchard 2012), HyDe (Blischak 2018), QuIBL (Edelman 2019), sprime (Browning 2018), Twisst (Martin 2017), PhyloNet (Than 2008) for explicit phylogenetic networks, and qpAdm / qpGraph (Patterson 2012). Distinguish introgression from incomplete lineage sorting (ILS), ancestral structure, ghost-lineage admixture, and rate variation. Use when testing inter-species gene flow, dating admixture events, identifying introgressed segments, building phylogenetic networks for reticulate evolution, or applying the ABBAclustering (Koppetsch-Malinsky-Matschiner 2024) framework for divergent-species gene flow.
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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.
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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
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