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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.

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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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Use this skill when working with Brain Imaging Data Structure (BIDS) datasets: organizing neuroscience and biomedical data (MRI, EEG, MEG, iEEG, PET, microscopy, NIRS, motion capture, EMG, MR spectroscopy, behavioral), querying BIDS layouts, validating compliance, converting DICOM to BIDS, writing metadata sidecars, or creating BIDS derivatives.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Decide whether commonly-excluded patients (eating disorders, elderly ≥75, upper GI disease) can actually receive a GLP-1 receptor agonist. Use when a clinician asks "can I give semaglutide to a patient with binge eating disorder / anorexia / bulimia", "is liraglutide safe in an 80-year-old", "GLP-1 with GERD or chronic gastritis", "GLP-1 in sarcopenic elderly", or anytime a patient is being ruled out for GLP-1 therapy based on a perceived contraindication. Grounded in Gorgojo-Martínez 2023 §6 (Myths or Reality).

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Apply the four published expert-consensus clinical scenarios to manage GI adverse events in complex GLP-1 receptor agonist patients — persistent nausea mid-titration, GERD/heartburn after up-titration, elderly with sarcopenia risk, and insulin-treated elderly with CKD plus diarrhoea. Use when a clinician describes a patient resembling one of these archetypes, or asks "how to manage GLP-1 in an elderly patient with CKD", "patient on liraglutide developed reflux", "sarcopenia worry on semaglutide in 80-year-old", or "persistent nausea on semaglutide despite escalation". Grounded in Gorgojo-Martínez 2023 Table 4.

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Recommends mineralocorticoid receptor antagonists for all primary aldosteronism patients to prevent target organ damage, irrespective of blood pressure control or serum potassium levels. Triggered when a clinician encounters a PA patient with well‑controlled BP and normal K and wonders, 'Do I still need to treat with MRA?' or considers stopping therapy.

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Generate production-ready manga pages, chapter pages, covers, and panel sequences with strict recurring-character consistency. Use this when the user asks for a manga page, manga scene, chapter page, comic page, storyboard page, or character-consistent page generation. Before generating any page, inspect `img-memory`, create missing character sprites/reference sheets, make those images visible to image generation, then generate the final manga page.

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Search, create, and manage notes in the Obsidian vault with wikilinks and index notes. Use when user wants to find, create, or organize notes in Obsidian.

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Structures git workflow practices. Use when making any code change. Use when committing, branching, resolving conflicts, or when you need to organize work across multiple parallel streams.

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Atlassian Template and Files Creator/Modifier expert for creating, modifying, and managing Jira and Confluence templates, blueprints, custom layouts, reusable components, and standardized content structures. Use when building org-wide templates, custom blueprints, page layouts, and automated content generation.

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Automate Apollo.io lead generation -- search organizations, discover contacts, enrich prospect data, manage contact stages, and build targeted outreach lists -- using natural language through the Composio MCP integration.

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Automate Anthropic Admin tasks via Rube MCP (Composio): API keys, usage, workspaces, and organization management. Always search tools first for current schemas.

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Automate SEO research with Ahrefs -- analyze backlink profiles, research keywords, track domain metrics history, audit organic rankings, and perform batch URL analysis through the Composio Ahrefs integration.

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Memory is the cornerstone of intelligent agents. Without it, every interaction starts from zero. This skill covers the architecture of agent memory: short-term (context window), long-term (vector stores), and the cognitive architectures that organize them.

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Analyze Amazon product, sales, Amazon Ads, retail-readiness, and Best Seller Rank data to find commercially actionable growth opportunities. Use when Codex needs to identify which ASINs, campaigns, keywords, search terms, product targets, placements, categories, or BSR movements deserve more investment, optimization, harvesting, bid/budget changes, retail-readiness fixes, investigation, protection, or controlled scaling across Sponsored Products, Sponsored Brands, Sponsored Display, search term reports, targeting reports, campaign reports, placement reports, advertised/purchased product reports, Business Reports, organic performance, and BSR history.

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Guide for creating and managing slash commands in Claude Code. Use when (1) creating new slash commands, (2) learning command syntax and features, (3) deciding between commands vs skills, (4) implementing advanced command features (arguments, hooks, bash execution), or (5) organizing and managing command libraries.

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Generates complete features from natural language — components, API routes, migrations, types, and tests.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level physiology covering organ system function, homeostasis, cardiovascular physiology, respiratory physiology, renal physiology, endocrinology, and integrative physiology.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level marine biology covering ocean ecosystems, marine organisms, coral reef ecology, deep sea biology, fisheries science, ocean chemistry, and marine conservation.

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Check macOS GHA runner status for the getditto org

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Structural editor that proposes cuts, reorganization, and simplification while preserving comprehension. Use when user requests structural review or editorial review of structure

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Splits large markdown documents into smaller, organized files based on level 2 (default) sections. Use if the user says perform shard document

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Find, build, evaluate, and improve systems using decision models. Use for bounded classification, routing, ranking, Choice/Score/Noul, decision-model composition, evaluation harnesses, prompt/program hill climbing, and Software 3.0 workflows across software, business, organizations, and life. Separate models, code, and human judgment. TypeSafe Jev is the default hosted exemplar. Not for straightforward arithmetic, prose rewriting, or provider setup alone.

日本語の概要は準備中です。原文の説明を表示しています。